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AEG 3482 - ≥99%(HPLC), high purity , CAS No.63735-71-7

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AEG 3482 - ≥99%(HPLC), high purity , CAS No.63735-71-7

COA

Grade & Purity:

≥99%(HPLC)

Cas Number: 63735-71-7
Molecular Weight: 280.33
PubChem CID: 698112

In stock

Item Number

A287091

Grouped product items
SKU	Size	Availability	Price
A287091-5mg	5mg	3	$98.90
A287091-10mg	10mg	3	$157.90
A287091-25mg	25mg	3	$345.90
A287091-50mg	50mg	2	$543.90
A287091-100mg	100mg	2	$939.90

Inhibitor of JNK signaling

View related series

Apoptosis (4276) JNK (62) MAPK/ERK Pathway (546)

Basic Description

Synonyms	6-phenylimidazo[2,1-b][1,3,4]thiadiazole-2-sulfonamide \| NCGC00167812-02 \| Q27195229 \| NCGC00167812-06 \| Oprea1_698164 \| SCHEMBL2540289 \| 7EZF1A283N \| HMS3677N15 \| BCP01890 \| CCG-221955 \| NCGC00167812-01 \| HY-107599 \| AEG3482 \| AEG-3482 \| HMS1538B12 \| Imi
Specifications & Purity	≥99%(HPLC)
Biochemical and Physiological Mechanisms	Inhibitor of c-jun N-terminal kinase (JNK) signaling. Binds Hsp90 and facilitates HSF1 release, induces expression of Hsp70, which in turn blocks JNK activation and JNK-dependent apoptosis. Antiapoptotic; inhibits NGF withdrawal-induced death in SCG neuro
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Azoles
    - Subclass Imidazoles
      - Level5 Substituted imidazoles
        Level6 Phenylimidazoles

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Azoles
Subclass	Imidazoles
Intermediate Tree Nodes	Substituted imidazoles
Direct Parent	Phenylimidazoles
Alternative Parents	Thiadiazole sulfonamides Organosulfonamides N-substituted imidazoles Benzene and substituted derivatives Heteroaromatic compounds Aminosulfonyl compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	5-phenylimidazole - 4-phenylimidazole - 1,3,4-thiadiazole-2-sulfonamide - Monocyclic benzene moiety - N-substituted imidazole - Organosulfonic acid amide - Benzenoid - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Heteroaromatic compound - Sulfonyl - Thiadiazole - Aminosulfonyl compound - Azacycle - Organic oxide - Organopnictogen compound - Organic oxygen compound - Hydrocarbon derivative - Organonitrogen compound - Organosulfur compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as phenylimidazoles. These are polycyclic aromatic compounds containing a benzene ring linked to an imidazole ring through a CC or CN bond.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)

Discover Target: MEN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rorc Nuclear receptor ROR-gamma (89407 Activities)

Discover Target: Rorc

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	6-phenylimidazo[2,1-b][1,3,4]thiadiazole-2-sulfonamide
INCHI	InChI=1S/C10H8N4O2S2/c11-18(15,16)10-13-14-6-8(12-9(14)17-10)7-4-2-1-3-5-7/h1-6H,(H2,11,15,16)
InChIKey	MQUYTXDAVCOCMX-UHFFFAOYSA-N
Smiles	C1=CC=C(C=C1)C2=CN3C(=N2)SC(=N3)S(=O)(=O)N
Isomeric SMILES	C1=CC=C(C=C1)C2=CN3C(=N2)SC(=N3)S(=O)(=O)N
WGK Germany	3
Molecular Weight	280.33
Reaxy-Rn	1007641
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1007641&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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6 results found

Lot Number	Certificate Type	Date	Item
A2306434	Certificate of Analysis	Oct 24, 2022	A287091
A2306435	Certificate of Analysis	Oct 24, 2022	A287091
C2528278	Certificate of Analysis	Oct 24, 2022	A287091
A2306431	Certificate of Analysis	Oct 24, 2022	A287091
A2306433	Certificate of Analysis	Oct 24, 2022	A287091
A2306437	Certificate of Analysis	Oct 24, 2022	A287091

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 28.03, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 1.4, Max Conc. mM: 5
Molecular Weight	280.300 g/mol
XLogP3	1.400
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Exact Mass	280.009 Da
Monoisotopic Mass	280.009 Da
Topological Polar Surface Area	127.000 Å²
Heavy Atom Count	18
Formal Charge	0
Complexity	405.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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