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Acarbose Hydrate - ≥98%, high purity , CAS No.56180-94-0, Inhibitor of amylase alpha 2A;Inhibitor of maltase-glucoamylase

167 Citations COA COA
In stock
Item Number
A129816
Grouped product items
SKU Size
Availability
 Price Qty
A129816-250mg
250mg
4
$44.90
A129816-1g
1g
5
$89.90
A129816-5g
5g
2
$269.90
A129816-10g
10g
1
$431.90
A129816-25g
25g
1
$863.90
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Bulk Order  SDS  DATASHEET  Specification Sheet

Potent α-glucosidase inhibitor

View related series
amylase alpha 2A Inhibitor (1) Glucose Metabolism (1943) Glucosidase (71) maltase-glucoamylase Inhibitor (2) Metabolic Enzyme/Protease (4860)

Basic Description

Synonyms Bay-g 5421 | BAY g 5421 | Bay g 5421 | BRD-A16444946-001-07-1 | MLS001424056 | AB00639959-06 | HMS2093I22 | MFCD00869592 | Prandase; | SR-01000759407 | SBI-0206777.P001 | acarbose | MD-0230 | SR-01000759407-4 | Acarbose; O-4,6-Dideoxy-4-[[(1S,4R,5S,6S)-4,
Specifications & Purity Moligand™, ≥98%
Biochemical and Physiological Mechanisms Potent α-glucosidase inhibitor (IC 50 = 11 nM). Orally active. Antidiabetic.
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type INHIBITOR
Mechanism of action Inhibitor of amylase alpha 2A;Inhibitor of maltase-glucoamylase
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Acarbose, also known as BAY g 5421, is an α-glucosidase inhibitor that prevents absorption of sucrose and maltose. This compound has been found to delay digestion of complex disaccharides and carbohydrates. Further studies suggest that this compound can stimulate phosphorylase kinase (PhK) by binding to the glucoamylase-like domain new the amino termini and causing an alteration in the structure.
An α-glucosidase inhibitor


Application：

Acarbose, a derivitized maltotriose antidiabetic drug, is a reversible α-glucosidase inhibitor used in medical studies to control the effects of Type II diabetes. Acarbose is often used as a reference to which other α-glucosidase inhibitors are compared.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic oxygen compounds
Class Organooxygen compounds
Subclass Carbohydrates and carbohydrate conjugates
Intermediate Tree Nodes Aminosaccharides - Aminoglycosides
Direct Parent Aminocyclitol glycosides
Alternative Parents Oligosaccharides  O-glycosyl compounds  Oxanes  Cyclitols and derivatives  Secondary alcohols  Hemiacetals  1,2-aminoalcohols  Polyols  Oxacyclic compounds  Dialkylamines  Acetals  Primary alcohols  Organopnictogen compounds  Hydrocarbon derivatives  
Molecular Framework Aliphatic heteromonocyclic compounds
Substituents Oligosaccharide - Amino cyclitol glycoside - Glycosyl compound - O-glycosyl compound - Cyclitol or derivatives - Oxane - 1,2-aminoalcohol - Hemiacetal - Secondary alcohol - Secondary amine - Organoheterocyclic compound - Acetal - Oxacycle - Secondary aliphatic amine - Polyol - Organonitrogen compound - Organic nitrogen compound - Hydrocarbon derivative - Organopnictogen compound - Amine - Primary alcohol - Alcohol - Aliphatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as aminocyclitol glycosides. These are organic compounds containing an amicocyclitol moiety glycosidically linked to a carbohydrate moiety. There are two major classes of aminoglycosides containing a 2-streptamine core. They are called 4,5- and 4,6-disubstituted 2-deoxystreptamines.
External Descriptors tetrasaccharide derivative

Associated Targets(Human)

MGAM Tclin Maltase-glucoamylase, intestinal (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
AMY2A Tclin Pancreatic alpha-amylase (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid 488183332
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488183332
IUPAC Name (3R,4R,5S,6R)-5-[(2R,3R,4R,5S,6R)-5-[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino]oxan-2-yl]oxy-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-(hydroxymethyl)oxane-2,3,4-triol
INCHI InChI=1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12-,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23?,24-,25-/m1/s1
InChIKey XUFXOAAUWZOOIT-UGEKTDRHSA-N
Smiles CC1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)NC4C=C(C(C(C4O)O)O)CO
Isomeric SMILES C[C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@@H]2[C@H](O[C@@H]([C@@H]([C@H]2O)O)O[C@@H]3[C@H](OC([C@@H]([C@H]3O)O)O)CO)CO)O)O)N[C@H]4C=C([C@H]([C@@H]([C@H]4O)O)O)CO
RTECS LZ7153000
Molecular Weight 645.61(as Anhydrous)
Reaxy-Rn 24713589
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24713589&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

34 results found

Lot Number Certificate Type Date Item
H2321101 Certificate of Analysis Jun 09, 2025 A129816
D2530086 Certificate of Analysis Apr 18, 2025 A129816
D2530085 Certificate of Analysis Apr 18, 2025 A129816
D2530087 Certificate of Analysis Apr 18, 2025 A129816
D2530095 Certificate of Analysis Apr 18, 2025 A129816
D2530096 Certificate of Analysis Apr 18, 2025 A129816
C2304160 Certificate of Analysis Dec 06, 2024 A129816
C2304157 Certificate of Analysis Dec 06, 2024 A129816
K2422280 Certificate of Analysis Nov 09, 2024 A129816
K2422279 Certificate of Analysis Nov 09, 2024 A129816
K2422281 Certificate of Analysis Nov 09, 2024 A129816
I2424121 Certificate of Analysis Sep 05, 2024 A129816
I2424122 Certificate of Analysis Sep 05, 2024 A129816
I2424123 Certificate of Analysis Sep 05, 2024 A129816
I2424124 Certificate of Analysis Sep 05, 2024 A129816
G2411232 Certificate of Analysis Jun 14, 2024 A129816
G2411233 Certificate of Analysis Jun 14, 2024 A129816
G2411238 Certificate of Analysis Jun 14, 2024 A129816
G2411239 Certificate of Analysis Jun 14, 2024 A129816
G2411242 Certificate of Analysis Jun 14, 2024 A129816
G2411243 Certificate of Analysis Jun 14, 2024 A129816
E2414008 Certificate of Analysis Jan 05, 2024 A129816
E2113057 Certificate of Analysis Feb 13, 2023 A129816
E2113058 Certificate of Analysis Feb 13, 2023 A129816
E2113060 Certificate of Analysis Feb 13, 2023 A129816
J2307076 Certificate of Analysis Feb 18, 2022 A129816
C2223160 Certificate of Analysis Feb 18, 2022 A129816
C2223149 Certificate of Analysis Feb 18, 2022 A129816
C2223142 Certificate of Analysis Feb 18, 2022 A129816
C2223127 Certificate of Analysis Feb 18, 2022 A129816
D2310198 Certificate of Analysis Feb 18, 2022 A129816
C2223169 Certificate of Analysis Feb 18, 2022 A129816
E2420045 Certificate of Analysis Feb 18, 2022 A129816
I2318159 Certificate of Analysis Feb 18, 2022 A129816

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Chemical and Physical Properties

Solubility Soluble in water (100 mM), DMSO (100 mM), and methanol.
Specific Rotation[α] 176° (C=1,H2O)
Molecular Weight 645.600 g/mol
XLogP3 -8.500
Hydrogen Bond Donor Count 14
Hydrogen Bond Acceptor Count 19
Rotatable Bond Count 9
Exact Mass 645.248 Da
Monoisotopic Mass 645.248 Da
Topological Polar Surface Area 321.000 Ų
Heavy Atom Count 44
Formal Charge 0
Complexity 962.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 18
Undefined Atom Stereocenter Count 1
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Alternative Products

  1. Acarbose Hydrate, Maltase-glucoamylase inhibitor
    Acarbose Hydrate, Maltase-glucoamylase inhibitor

    Starting at $166.90

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