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Abituzumab (anti-ITGAV) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to ITGAV, >95%, high purity, Human IgG2, INHIBITOR of Integrin alpha-V/beta-1 inhibitor, INHIBITOR of Integrin alpha-V/beta-1 inhibitor

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human
  • Isotype: Human IgG2
  • Conjugation: Unconjugated
In stock
Item Number
Ab170472
Grouped product items
SKU Size
Availability
Price Qty
Ab170472-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$59.90
Ab170472-1mg
1mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$288.90
Ab170472-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$687.90
Ab170472-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,077.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG2; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Abituzumab (anti-ITGAV) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to ITGAV, >95%, high purity, Human IgG2, INHIBITOR of Integrin alpha-V/beta-1 inhibitor
Synonyms Abituzumab | antigen identified by monoclonal antibody L230 antibody | CD 51 antibody | CD51 antibody | DKFZp686A08142 antibody | Integrin alpha five antibody | integrin alpha V beta 3 antibody | Integrin alpha-5 antibody | integrin alpha-V antibody | Int
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity ITGAV
Application ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of Integrin alpha-V/beta-1 inhibitor
Product Description

Abituzumab (anti-ITGAV) is a recombinant monoclonal antibody to ITGAV. Abituzumab effectively reduces the phosphorylation of FAK, Akt and ERK. Abituzumab can be used in cancer research, particularly in prostate cancer.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Antibody Type Primary antibody
Clonality Recombinant
Isotype Human IgG2
Light Chain Type kappa
SDS-PAGE 27.2 kDa (Light Chain) & 52.6 kDa (Heavy Chain), under reducing conditions; 175.0 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Source CHO supernatant
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1105038-73-0

Associated Targets(Human)

ITGAV Tchem Integrin alpha-V (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ITGAV Tchem Vitronectin receptor alpha (65 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGAV Tchem Integrin alpha-V/beta-5 (589 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGAV Tchem Integrin alpha-V/beta-6 (509 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGAV Tchem Integrin alpha-V/beta-8 (181 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Abituzumab (anti-ITGAV) (Ab170472) - Flow Cytometry
Flow Cytometry analysis of A549 cells labelling ITGAV (red) with Abituzumab (anti-ITGAV) (Ab170472). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Abituzumab (anti-ITGAV) (Ab170472) - SEC
The purity of Abituzumab (anti-ITGAV) (Ab170472) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ23F0900973 Certificate of Analysis Sep 06, 2023 Ab170472
ZJ23F0900974 Certificate of Analysis Sep 06, 2023 Ab170472

Citations of This Product

1. Xiuquan Jia, Jiping Ma, Min Wang, Zhongtian Du, Fang Lu, Feng Wang, Jie Xu.  (2014)  Promoted role of Cu(NO3)2 on aerobic oxidation of 5-hydroxymethylfurfural to 2,5-diformylfuran over VOSO4.  APPLIED CATALYSIS A-GENERAL,  482  (231). 

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