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Basic Description
| Synonyms | BRN 0386133 | 1-naphthyl amine | alpha-Naftalamin | RCRA waste no. U167 | 1-amino napthalene | 1-Naftilamina | 1-Naphthylamin [German] | CI Azoic Diazo Component 114 | STK301604 | 1-Aminonaftalen [Czech] | 1-Naftylamin [Czech] | 1-Naphthylamine, analytica |
|---|---|
| Specifications & Purity | AR, ≥99% |
| Storage Temp | Store at 2-8°C,Argon charged |
| Shipped In |
Wet ice This product requires cold chain shipping. Ground and other economy services are not available. |
| Grade | AR |
| Product Description |
1-Naphthylamine has been used in the synthesis of Pitnot-2, an inactive analog of clathrin inhibitor Pitstop 2. It can also be used as a starting material to synthesize: · [(S)-HY-Phos], a novel chiral phosphine-phosphoramidite ligand for use in rhodium-catalyzed asymmetric hydrogenation of various functionalized olefins. · N-(naphthalen-1-yl)picolinamide. |
Taxonomic Classification
Taxonomy Tree
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Kingdom
Organic compounds
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Superclass
Benzenoids
- Class Naphthalenes
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Superclass
Benzenoids
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Class | Naphthalenes |
| Subclass | Not available |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Naphthalenes |
| Alternative Parents | Primary amines Organopnictogen compounds Hydrocarbon derivatives |
| Molecular Framework | Aromatic homopolycyclic compounds |
| Substituents | Naphthalene - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Primary amine - Organonitrogen compound - Amine - Aromatic homopolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as naphthalenes. These are compounds containing a naphthalene moiety, which consists of two fused benzene rings. |
| External Descriptors | naphthylamine |
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Associated Targets(Human)
TSHR
Tclin
Thyroid stimulating hormone receptor (29986 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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AHR
Tclin
Aryl hydrocarbon receptor (1071 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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ALB
Tchem
Serum albumin (2651 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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ALDH1A1
Tchem
Aldehyde dehydrogenase 1A1 (77053 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
UGT1A4
Tbio
UDP-glucuronosyltransferase 1A4 (288 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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CYP3A4
Tclin
Cytochrome P450 3A4 (53859 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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NCI-H1299 (3248 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Lymphoblastoid cell (5959 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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HSD17B10
Tchem
Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
APEX1
Tchem
DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
UGT2B15
Tbio
UDP-glucuronosyltransferase 2B15 (172 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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UGT1A1
Tchem
UDP-glucuronosyltransferase 1-1 (448 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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HPGD
Tchem
15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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UGT1A6
Tbio
UDP-glucuronosyltransferase 1-6 (221 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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UGT1A7
Tbio
UDP-glucuronosyltransferase 1-7 (106 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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UGT1A9
Tbio
UDP-glucuronosyltransferase 1-9 (343 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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UGT1A10
Tbio
UDP-glucuronosyltransferase 1-10 (257 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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UGT2A1
UDP-glucuronosyltransferase 2A1 (59 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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KAT8
Tchem
Histone acetyltransferase KAT8 (178 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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KEAP1
Tclin
Kelch-like ECH-associated protein 1 (1736 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Associated Targets(non-human)
Abcb1b
P-glycoprotein 1 (174 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Polycyclic aromatic hydrocarbon binding protein (16 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Nfe2l2
Nuclear factor erythroid 2-related factor 2 (214 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| Pubchem Sid | 504751709 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504751709 |
| IUPAC Name | naphthalen-1-amine |
| INCHI | InChI=1S/C10H9N/c11-10-7-3-5-8-4-1-2-6-9(8)10/h1-7H,11H2 |
| InChIKey | RUFPHBVGCFYCNW-UHFFFAOYSA-N |
| Smiles | C1=CC=C2C(=C1)C=CC=C2N |
| Isomeric SMILES | C1=CC=C2C(=C1)C=CC=C2N |
| WGK Germany | 2 |
| RTECS | QM1400000 |
| UN Number | 2077 |
| Packing Group | III |
| Molecular Weight | 143.19 |
| Beilstein | 386133 |
| Reaxy-Rn | 386133 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=386133&ln= |
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 F2121245 |
Certificate of Analysis | Apr 03, 2025 | N103784 |
| B2517338 |
Certificate of Analysis | Jan 04, 2025 | N103784 |
| A2514584 |
Certificate of Analysis | Jan 04, 2025 | N103784 |
| B2508462 |
Certificate of Analysis | Jan 04, 2025 | N103784 |
| B2508470 |
Certificate of Analysis | Jan 04, 2025 | N103784 |
| D2524064 |
Certificate of Analysis | Jan 04, 2025 | N103784 |
| G2422108 |
Certificate of Analysis | Jul 24, 2024 | N103784 |
| B2307750 |
Certificate of Analysis | Dec 30, 2022 | N103784 |
| B2307720 |
Certificate of Analysis | Dec 30, 2022 | N103784 |
| B2307826 |
Certificate of Analysis | Dec 30, 2022 | N103784 |
| B2307704 |
Certificate of Analysis | Dec 30, 2022 | N103784 |
| H2301179 |
Certificate of Analysis | Dec 30, 2022 | N103784 |
| B2307880 |
Certificate of Analysis | Dec 30, 2022 | N103784 |
| B2307746 |
Certificate of Analysis | Dec 30, 2022 | N103784 |
| K2216293 |
Certificate of Analysis | Nov 21, 2022 | N103784 |
| I2224572 |
Certificate of Analysis | Jun 18, 2022 | N103784 |
| I2224574 |
Certificate of Analysis | Jun 18, 2022 | N103784 |
| J2312052 |
Certificate of Analysis | Jun 18, 2022 | N103784 |
| I2224575 |
Certificate of Analysis | Jun 18, 2022 | N103784 |
| I2224573 |
Certificate of Analysis | Jun 18, 2022 | N103784 |
| I2224570 |
Certificate of Analysis | Jun 18, 2022 | N103784 |
| F2202290 |
Certificate of Analysis | Jun 07, 2022 | N103784 |
| H2301103 |
Certificate of Analysis | Jun 23, 2021 | N103784 |
| F2121238 |
Certificate of Analysis | Jun 23, 2021 | N103784 |
| H2412513 |
Certificate of Analysis | Jun 23, 2021 | N103784 |
| H2330050 |
Certificate of Analysis | Jun 23, 2021 | N103784 |
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Chemical and Physical Properties
| Solubility | Solubility in dilute Acetic acid almost transparency; |
|---|---|
| Sensitivity | Light and Air sensitive |
| Flash Point(°F) | 314.6 °F |
| Flash Point(°C) | 157℃ |
| Boil Point(°C) | 301°C |
| Melt Point(°C) | 50°C |
| Molecular Weight | 143.180 g/mol |
| XLogP3 | 2.200 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 0 |
| Exact Mass | 143.073 Da |
| Monoisotopic Mass | 143.073 Da |
| Topological Polar Surface Area | 26.000 Ų |
| Heavy Atom Count | 11 |
| Formal Charge | 0 |
| Complexity | 133.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
Alternative Products
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1-NaphthylamineStarting at $207.90
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