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1,1-Diphenyl-4-piperidino-1-butanol Hydrochloride - 99%, high purity , Muscarinic acetylcholine receptor M1 antagonist, CAS No.3254-89-5, Muscarinic acetylcholine receptor M1 antagonist

COA COA
    Grade & Purity:
  • ≥99%
In stock
Item Number
D124789
Grouped product items
SKU Size
Availability
 Price Qty
D124789-5g
5g
5
$32.90
D124789-25g
25g
5
$123.90
D124789-100g
100g
1
$444.90
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Bulk Order  SDS  DATASHEET  Specification Sheet
View related series
alcohol (850) Class A GPCR (4138) GPCR/G Protein (3172) Ion channel (2197) mAChR (182) Membrane Transporter/Ion Channel (1822) Neuronal Signaling (3320) Oxygenated compounds (806) Sodium Channel (211)

Basic Description

Synonyms Diphenidol hydrochloride | DTXCID20108739 | EINECS 221-850-0 | Diphenidol hydrochloride, >=98% (HPLC) | 1,1-Diphenyl-4-piperidino-1-butanol | Q27276383 | Vontrol (TN) | DIPHENIDOL HYDROCHLORIDE [MI] | Pineroro | SKF 478-A | DIFENIDOL HYDROCHLORIDE [JAN] |
Specifications & Purity ≥99%
Biochemical and Physiological Mechanisms Diphenidol is a non-selective muscarinic acetylcholine receptor antagonist. Diphenidol is an antiemetic agent used in the treatment of vomiting and vertigo.
Shipped In Normal
Action Type ANTAGONIST
Mechanism of action Muscarinic acetylcholine receptor M1 antagonist
Product Description

A muscarinic antagonist.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Benzenoids
Class Benzene and substituted derivatives
Subclass Diphenylmethanes
Intermediate Tree Nodes Not available
Direct Parent Diphenylmethanes
Alternative Parents Phenylbutylamines  Aralkylamines  Piperidines  Tertiary alcohols  Trialkylamines  Azacyclic compounds  Organopnictogen compounds  Hydrochlorides  Hydrocarbon derivatives  Aromatic alcohols  
Molecular Framework Aromatic heteromonocyclic compounds
Substituents Diphenylmethane - Phenylbutylamine - Aralkylamine - Piperidine - Tertiary alcohol - Tertiary amine - Tertiary aliphatic amine - Azacycle - Organoheterocyclic compound - Hydrochloride - Alcohol - Hydrocarbon derivative - Organopnictogen compound - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Aromatic alcohol - Amine - Aromatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
External Descriptors Not available

Associated Targets(Human)

CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM4 Tclin Muscarinic acetylcholine receptor M4 (6041 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM5 Tclin Muscarinic acetylcholine receptor M5 (4677 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM3 Tclin Muscarinic acetylcholine receptor M3 (7750 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HEK293 (82097 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

ampC Beta-lactamase AmpC (62480 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mapk1 MAP kinase ERK2 (650 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Canis familiaris (36305 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 488183766
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488183766
IUPAC Name 1,1-diphenyl-4-piperidin-1-ylbutan-1-ol;hydrochloride
INCHI InChI=1S/C21H27NO.ClH/c23-21(19-11-4-1-5-12-19,20-13-6-2-7-14-20)15-10-18-22-16-8-3-9-17-22;/h1-2,4-7,11-14,23H,3,8-10,15-18H2;1H
InChIKey AVZIYZHXZAYGJS-UHFFFAOYSA-N
Smiles C1CCN(CC1)CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O.Cl
Isomeric SMILES C1CCN(CC1)CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O.Cl
RTECS TM4970500
Molecular Weight 345.91
Reaxy-Rn 3760108
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3760108&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
L2215158 Certificate of Analysis Nov 08, 2022 D124789
L2215261 Certificate of Analysis Nov 08, 2022 D124789
L2215191 Certificate of Analysis Nov 08, 2022 D124789

Chemical and Physical Properties

Solubility Very soluble in Methanol; Soluble in Ethanol,Chloroform; Insoluble in Ether,Benzene
Sensitivity Moisture sensitive.
Melt Point(°C) 214 °C
Molecular Weight 345.900 g/mol
XLogP3
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 2
Rotatable Bond Count 6
Exact Mass 345.186 Da
Monoisotopic Mass 345.186 Da
Topological Polar Surface Area 23.500 Ų
Heavy Atom Count 24
Formal Charge 0
Complexity 307.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 2

Solution Calculators

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