| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Z650609-5mg |
5mg |
期货  |
|
| 别名 | 玉米黄质二棕榈酸酯 |
|---|---|
| 英文别名 | NCGC00182606-01 | .BETA.,.BETA.-CAROTENE-3,3'-DIOL, 3,3'-DIHEXADECANOATE, (3R,3'R)- | PHYSALIEN, ALL-TRANS- | CAS-144-67-2 | .BETA.-CAROTENE-3,3'-DIOL, DIPALMITATE, ALL-TRANS- | EINECS 205-635-9 | XACHQDDXHDTRLX-XLVVAOPESA-N | Piceid (cis-) | 570944I2YB | |
| 规格或纯度 | ≥95% |
| 英文名称 | Zeaxanthin dipalmitate |
| 生化机理 | 玉米黄质二棕榈酸酯（Physalien）是一种源自枸杞的类胡萝卜素，具有抗炎和抗氧化作用。玉米黄质二棕榈酸酯与 p2X7 受体（K d =81.2 nM）和脂肪直通素受体 1（AdipoR1；K d =533 nM）直接相互作用。 |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Zeaxanthin dipalmitate (Physalien) is a wolfberry-derived carotenoid, has anti-inflammatory and anti-oxidative stress effects. Zeaxanthin dipalmitate directly interact with p2X7 receptor ( K d =81.2 nM) and adiponectin receptor 1 ( AdipoR1 ; K d =533 nM) in a positive dose-dependent manner. Zeaxanthin dipalmitate restores mitochondrial autophagy functions suppressed by ethanol intoxication. Zeaxanthin dipalmitate can be used in the research of alcoholic fatty liver disease (AFLD) and retinitis pigmentosa (RP) In Vitro Zeaxanthin dipalmitate (1 µM; 2 h) totally or partially reverses the down-regulation of Atg5, beclin-1, and LC3A/B by ethanol (250 mM), and the up-regulation of p62 by ethanol in BRL-3A cells. Zeaxanthin dipalmitate (1 µM; 2 h) partially recovers the ethanol-suppressed LC3B in BRL-3A cells. Zeaxanthin dipalmitate (1 µM; 2 h) partially recovers the ethanol-suppressed cell viability and ethanol-induced aspase-3/7 activity of BRL-3A cells. Zeaxanthin dipalmitate (1 µM; 2 h) recovers the ethanol-induced inhibition of mitophagy in BRL-3A cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Zeaxanthin dipalmitate (10 mg/kg; p.o.; daily for 2 weeks) reduces the serum ALT and AST levels increased by long-term ethanol challenge in at AFLD Model . Zeaxanthin dipalmitate (10 mg/kg; p.o.; daily for 2 weeks) effectively attenuates the histological injury . Zeaxanthin dipalmitate (10 mg/kg; p.o.; daily for 2 weeks) attenuates the AFLD-induced hepatic apoptosis (reveal by caspase-3/7 activity) and inflammation (TNF-α) in rat . Zeaxanthin dipalmitate (approximately 4 μM; intravitreal injection for once) improves the visual behavior of rd10 mice and delays the degeneration of retinal photoreceptors. Zeaxanthin dipalmitate (approximately 4 μM; intravitreal injection for once) improves the light responses of photoreceptors, bipolar cells and retinal ganglion cells. Zeaxanthin dipalmitate (approximately 4 μM; intravitreal injection for once) reduces the expression of genes that are involved in inflammation, apoptosis and oxidative stress in rd10 mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:p2X7/AdipoR1 receptor |
| 纯度 | ≥95% |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 205-635-9 |
|---|---|
| 分子类型 | 未知 |
| IIUPAC Name | [(1R)-4-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-18-[(4R)-4-hexadecanoyloxy-2,6,6-trimethylcyclohexen-1-yl]-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaenyl]-3,5,5-trimethylcyclohex-3-en-1-yl] hexadecanoate |
| INCHI | 1S/C72H116O4/c1-13-15-17-19-21-23-25-27-29-31-33-35-37-49-69(73)75-65-55-63(7)67(71(9,10)57-65)53-51-61(5)47-41-45-59(3)43-39-40-44-60(4)46-42-48-62(6)52-54-68-64(8)56-66(58-72(68,11)12)76-70(74)50-38-36-34-32-30-28-26-24-22-20-18-16-14-2/h39-48,51-54,65-66H,13-38,49-50,55-58H2,1-12H3/b40-39+,45-41+,46-42+,53-51+,54-52+,59-43+,60-44+,61-47+,62-48+/t65-,66-/m1/s1 |
| InChi Key | XACHQDDXHDTRLX-XLVVAOPESA-N |
| Smiles | CCCCCCCCCCCCCCCC(=O)OC1CC(=C(C(C1)(C)C)C=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC2=C(CC(CC2(C)C)OC(=O)CCCCCCCCCCCCCCC)C)C)C)C |
| Isomeric SMILES | CCCCCCCCCCCCCCCC(=O)O[C@H]1CC(C(=C(C1)C)/C=C/C(=C/C=C/C(=C/C=C/C=C(/C=C/C=C(/C=C/C2=C(C[C@H](CC2(C)C)OC(=O)CCCCCCCCCCCCCCC)C)\C)\C)/C)/C)(C)C |
| 关联CAS | 144-67-2 |
| PubChem CID | 5281250 |
| MeSH Entry Terms | zeaxanthin dipalmitate |
| 分子量 | 1045.69 |
| 分子量 | 1045.700 g/mol |
|---|---|
| XLogP3 | 26.700 |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 42 |
| 精确质量Exact Mass | 1044.89 Da |
| 单同位素质量Monoisotopic Mass | 1044.89 Da |
| 拓扑极表面积Topological Polar Surface Area | 52.600 Ų |
| 重原子数Heavy Atom Count | 76 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 1850.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 2 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 9 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 9 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 1. Irma Belinda Yossa Nzeuwa, Baofu Guo, Ting Zhang, Liya Wang, Qian Ji, Hui Xia, Guiju Sun. (2019) Comparative Metabolic Profiling of Lycium Fruits (Lycium barbarum and Lycium chinense) from Different Areas in China and from Nepal. JOURNAL OF FOOD QUALITY, 2019 (4396027). [10.1155/2019/4396027] |
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