Z-WEHD-FMK

COA

级别和纯度:

≥98%

CAS编号: 210345-00-9
分子式: C₃₇H₄₂FN₇O₁₀
分子量: 763.77
PubChem编号: 25108687

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货号 (SKU)	包装规格	是否现货
Z646640-5mg	5mg	期货
Z646640-10mg	10mg	期货
Z646640-50mg	50mg	期货

查看相关系列

Amino Acid/Protein Metabolism (4559) Apoptosis (7108) Caspase (139) Cathepsin (64) Intrinsic Pathway (1438) Metabolic Enzyme/Protease (4889)

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基本描述

英文别名	benzyloxycarbonyl-Trp-Glu(OMe)-His-Asp(OMe)-fluoromethylketone \| HY-P0111 \| Caspase-1/ICE Inhibitor Z-WEHD-FMK \| Z-WEHD-FMK \| L-Histidinamide, N-[(phenylmethoxy)carbonyl]-L-tryptophyl-L- \| DTXSID80648727 \| methyl (4S)-5-[[(2S)-1-[[(3S)-5-fluoro-1-methoxy-
规格或纯度	≥98%
英文名称	Z-WEHD-FMK
生化机理	Z-WEHD-FMK 是一种强效、细胞渗透性和不可逆的 caspase-1/5 抑制剂。Z-WEHD-FMK 对 cathepsin B 的活性也有很强的抑制作用（IC 50 =6 μM）。Z-WEHD-FMK 可用于研究细胞凋亡的证据。
储存温度	干燥,-80℃储存
运输条件	超低温冰袋运输
产品介绍	Z-WEHD-FMK is a potent, cell-permeable and irreversible caspase-1/5 inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity ( IC 50 =6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis. In Vitro Z-WEHD-FMK (80 μM; 9 hours) elicits a near-complete blockage of C. trachomatis -induced cleavage of golgin-84 and increases GM130 expression in cells. Z-WEHD-FMK (30 min before being exposed to E. piscicida ) effectively inhibits 0909I E. piscicida induced ZF4 cells cytotoxicity and pyroptotic morphology. And in addition, it also inhibits the cytotoxicity induced by cytosolic LPS delivery. Z-WEHD-FMK (20 μM;18-24 hours following Cr 3+ ,Ni 2+ , and Co 2+ ) significantly induces a decrease of 76% to 86% in IL-1β release with 200 to 400 ppm Cr 3+ , it also induces a decrease of 35% to 45% with 48 ppm Ni 2+ or higher, Finally, this caspase-1 inhibitor induced a decrease with 6 ppm Co 2+ , down to a level below the detection threshold, and a decrease of 40% to 48% with 12 to 24 ppm Co 2+ in bone marrow-derived macrophages (BMDM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: C. trachomatis - or mock-infected HeLa cells Concentration: 80 μM Incubation Time: 9 hours Result: Increased golgin-84 and GM130 expression. Cell Viability AssayCell Line: Mycoplasma free-ZF4 cells Concentration: Incubation Time: 30 min before being exposed to E. piscicida Result: Inhibited ZF4 cells cytotoxicity and pyroptotic morphology. Form:Solid IC50& Target:Cathepsin B\|Caspase-1
纯度	≥98%

名称和识别符

IIUPAC Name	methyl (4S)-5-[[(2S)-1-[[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-4-[[(2S)-3-(1H-indol-3-yl)-2-(phenylmethoxycarbonylamino)propanoyl]amino]-5-oxopentanoate
INCHI	1S/C37H42FN7O10/c1-53-32(47)13-12-27(34(49)44-30(15-24-19-39-21-41-24)36(51)43-28(31(46)17-38)16-33(48)54-2)42-35(50)29(14-23-18-40-26-11-7-6-10-25(23)26)45-37(52)55-20-22-8-4-3-5-9-22/h3-11,18-19,21,27-30,40H,12-17,20H2,1-2H3,(H,39,41)(H,42,50)(H,43,51)(H,44,49)(H,45,52)/t27-,28-,29-,30-/m0/s1
InChi Key	NLZNSSWGRVBWIX-KRCBVYEFSA-N
Smiles	COC(=O)CCC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)OCC4=CC=CC=C4
Isomeric SMILES	COC(=O)CC[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)NC(=O)OCC4=CC=CC=C4
关联CAS	210345-00-9
PubChem CID	25108687
分子量	763.77

化学和物理性质

溶解性	DMSO : 100 mg/mL (130.93 mM; Need ultrasonic)
分子量	763.800 g/mol
XLogP3	2.000
氢键供体数Hydrogen Bond Donor Count	6
氢键受体数Hydrogen Bond Acceptor Count	12
可旋转键计数Rotatable Bond Count	23
精确质量Exact Mass	763.298 Da
单同位素质量Monoisotopic Mass	763.298 Da
拓扑极表面积Topological Polar Surface Area	240.000 Å²
重原子数Heavy Atom Count	55
形式电荷Formal Charge	0
复杂度Complexity	1330.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	4
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

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