| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Z358775-1mg |
1mg |
现货  |
|
| 英文别名 | 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2h-indol-2-one |
|---|---|
| 规格或纯度 | ≥98 atom% D,≥98% |
| 英文名称 | Ziprasidone-d8 |
| 储存温度 | 2-8°C储存 |
| 运输条件 | 冰袋运输 |
| 产品介绍 |
标记为齐普拉西酮。组合的血清素（5HT2）和多巴胺（D2）受体拮抗剂。用作抗精神病药。
齐拉西酮-d8是齐拉西酮的稳定同位素标记类似物，其中八个氢原子被氘取代。该化合物在研究中用作使用质谱技术（如液相色谱-串联质谱（LC-MS/MS））量化齐拉西酮的内标。将氘原子掺入分子中提供了质量差异，使得在分析测定中可以清楚地区分齐拉西酮-d8和非标记的齐拉西酮。研究人员利用齐拉西酮-d8研究齐拉西酮在各种生物基质中的吸收、分布、代谢和排泄（ADME）。这种氘代化合物在分析化学领域的应用特别有价值，可用于校准仪器和验证需要精确和准确测量实验和生物样品中齐拉西酮的方法。在需要了解齐拉西酮行为的研究中，使用齐拉西酮-d8有助于提高研究结果的可靠性。
Labelled Ziprasidone. Combined serotonin (5HT2) and dopamine (D2) receptor antagonist. Used as an antipsychotic.
Ziprasidone-d8 is a stable isotope-labeled analogue of ziprasidone, where eight hydrogen atoms are replaced with deuterium. This compound is utilized in research as an internal standard for the quantification of ziprasidone using mass spectrometric techniques, such as liquid chromatography-tandem mass spectrometry (LC-MS/MS). The incorporation of deuterium atoms into the molecule provides a mass difference that allows for the clear distinction between ziprasidone-d8 and the non-labeled ziprasidone in analytical assays. Researchers utilize ziprasidone-d8 to investigate the absorption, distribution, metabolism, and excretion (ADME) of ziprasidone in various biological matrices. The application of this deuterated compound is particularly valuable in the field of analytical chemistry to calibrate instruments and validate methodologies that require precise and accurate measurements of ziprasidone in experimental and biological samples. The use of ziprasidone-d8 aids in enhancing the reliability of research findings in studies where understanding the behavior of ziprasidone is critical.
|
| 纯度 | ≥98 atom% D,≥98% |
| IIUPAC Name | 5-[2-[4-(1,2-benzothiazol-3-yl)-2,2,3,3,5,5,6,6-octadeuteriopiperazin-1-yl]ethyl]-6-chloro-1,3-dihydroindol-2-one |
|---|---|
| INCHI | 1S/C21H21ClN4OS/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21/h1-4,11,13H,5-10,12H2,(H,23,27)/i7D2,8D2,9D2,10D2 |
| InChi Key | MVWVFYHBGMAFLY-UFBJYANTSA-N |
| Smiles | C1CN(CCN1CCC2=C(C=C3C(=C2)CC(=O)N3)Cl)C4=NSC5=CC=CC=C54 |
| Isomeric SMILES | [2H]C1(C(N(C(C(N1CCC2=C(C=C3C(=C2)CC(=O)N3)Cl)([2H])[2H])([2H])[2H])C4=NSC5=CC=CC=C54)([2H])[2H])[2H] |
| 关联CAS | 146939-27-7（unlabelled） |
| PubChem CID | 25216238 |
| 分子量 | 420.98 |
| 溶解性 | Soluble in DMSO and Methanol (Slightly) |
|---|---|
| 熔点 | >206° C (dec.) |
| 分子量 | 421.000 g/mol |
| XLogP3 | 4.000 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 5 |
| 可旋转键计数Rotatable Bond Count | 4 |
| 精确质量Exact Mass | 420.163 Da |
| 单同位素质量Monoisotopic Mass | 420.163 Da |
| 拓扑极表面积Topological Polar Surface Area | 76.700 Ų |
| 重原子数Heavy Atom Count | 28 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 573.000 |
| 同位素原子数Isotope Atom Count | 8 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS08 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H373: 通过长时间或反复暴露对器官造成损害 |
| 预防措施声明 |
P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P501: 将内容物/容器处理到。。。 P319: 如果你感到不适，请寻求医疗帮助。 |
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