| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| V646995-1mg |
1mg |
期货  |
|
| 别名 | 伏立诺他-d5 |
|---|---|
| 规格或纯度 | ≥99% |
| 英文名称 | Vorinostat-d5 |
| 生化机理 | Vorinostat-d5（SAHA-d5）是氘标记的Vorinostat。Vorinostat（SAHA）是一种对 HDAC1、HDAC2 和 HDAC3（I 类）、HDAC7（II 类）和 HDAC11（IV 类）具有强效口服活性的泛抑制剂，对 HDAC1 和 HDAC3 的 ID 50 值分别为 10 nM 和 20 nM。 |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Vorinostat-d5 (SAHA-d5) is the deuterium labeled Vorinostat. Vorinostat (SAHA) is a potent and orally active pan-inhibitor of HDAC1 , HDAC2 and HDAC3 (Class I) , HDAC7 (Class II) and HDAC11 (Class IV) , with ID 50 values of 10 nM and 20 nM for HDAC1 and HDAC3 , respectively. Vorinostat induces cell apoptosis. Vorinostat is also an effective inhibitor of human papillomaviruse (HPV)-18 DNA amplification. In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid |
| 纯度 | ≥99% |
| IIUPAC Name | N'-hydroxy-N-(2,3,4,5,6-pentadeuteriophenyl)octanediamide |
|---|---|
| INCHI | 1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)/i3D,4D,5D,8D,9D |
| InChi Key | WAEXFXRVDQXREF-YQYLVRRTSA-N |
| Smiles | C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO |
| Isomeric SMILES | [2H]C1=C(C(=C(C(=C1[2H])[2H])NC(=O)CCCCCCC(=O)NO)[2H])[2H] |
| PubChem CID | 25235331 |
| 分子量 | 269.35 |
| 分子量 | 269.350 g/mol |
|---|---|
| XLogP3 | 1.900 |
| 氢键供体数Hydrogen Bond Donor Count | 3 |
| 氢键受体数Hydrogen Bond Acceptor Count | 3 |
| 可旋转键计数Rotatable Bond Count | 8 |
| 精确质量Exact Mass | 269.179 Da |
| 单同位素质量Monoisotopic Mass | 269.179 Da |
| 拓扑极表面积Topological Polar Surface Area | 78.400 Ų |
| 重原子数Heavy Atom Count | 19 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 276.000 |
| 同位素原子数Isotope Atom Count | 5 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
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