基本描述

别名	万古霉素
英文别名	VANCOMYCIN HYDROCHLORIDE (EP MONOGRAPH) \| EN300-26256009 \| Vancocin hydrochloride in plastic container \| CCG-222571 \| VANCOMYCIN MONOHYDROCHLORIDE [MI] \| VANCOMYCINHYDROCHLORIDE \| VANCOMYCIN HYDROCHLORIDE [ORANGE BOOK] \| UNII-71WO621TJD \| DTXSID90891868 \|
规格或纯度	PharmPure™, USP, potency: ≥900 ug per mg
英文名称	Vancomycin HCL
生化机理	万古霉素是一种糖肽类抗生素，可在肽聚糖生物合成水平上阻断细菌细胞壁的生物合成。它能抑制 NAM/NAG 肽末端 D-丙氨酰-D-丙氨酸分子的结合。它对革兰氏阳性菌有效。万古霉素还能改变细菌细胞膜的渗透性和 RNA 的合成。抑制革兰氏阳性细菌细胞壁的合成。在体内具有药理活性。
储存温度	2-8°C储存,充氩
运输条件	冰袋运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	溶于水。为窄谱抗生素，仅对革兰阳性菌有效，如溶血性链球菌、肺炎球菌、淋球菌及肠球菌等均属敏感，对耐药金葡菌本品尤为敏感。其作用机制是抑制细菌细胞壁的合成，它主要和细菌细胞壁结合，而使某些氨基酸不能进入细胞壁的糖肽中。 Vancomycin, from Streptomyces orientalis, is used for the treatment of serious or severe infections caused by susceptible strains of methicillin-resistant (β-lactam-resistant) staphylococci. It is used to block bacterial cell wall biosynthesis at the level of peptidoglycan biosynthesis. It is widely studied in cancer patients.Vancomycin′s overuse has been studied, which has resulted in recommended guidelines.

名称和识别符

分子类型	小分子
IIUPAC Name	(1S,2R,18R,19R,22S,25R,28R,40S)-48-[(2S,3R,4S,5S,6R)-3-[(2S,4S,5S,6S)-4-amino-5-hydroxy-4,6-dimethyloxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-22-(2-amino-2-oxoethyl)-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[[(2R)-4-methyl-2-(methylamino)pentanoyl]amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentazaoctacyclo[26.14.2.23,6.214,17.18,12.129,33.010,25.034,39]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34(39),35,37,46,49-pentadecaene-40-carboxylic acid;hydrochloride
INCHI	1S/C66H75Cl2N9O24.ClH/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92;/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95);1H/t24-,34+,35-,42+,44-,46+,47+,48-,49+,50-,51+,52+,53+,54-,56+,57+,65-,66-;/m0./s1
InChi Key	LCTORFDMHNKUSG-XTTLPDOESA-N
Smiles	CC1C(C(CC(O1)OC2C(C(C(OC2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)C(C(C(=O)NC(C(=O)NC5C(=O)NC7C8=CC(=C(C=C8)O)C9=C(C=C(C=C9O)O)C(NC(=O)C(C(C1=CC(=C(O4)C=C1)Cl)O)NC7=O)C(=O)O)CC(=O)N)NC(=O)C(CC(C)C)NC)O)Cl)CO)O)O)(C)N)O.Cl
Isomeric SMILES	C[C@H]1[C@H]([C@@](C[C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)[C@H]([C@H](C(=O)N[C@H](C(=O)N[C@H]5C(=O)N[C@@H]7C8=CC(=C(C=C8)O)C9=C(C=C(C=C9O)O)[C@H](NC(=O)[C@H]([C@@H](C1=CC(=C(O4)C=C1)Cl)O)NC7=O)C(=O)O)CC(=O)N)NC(=O)[C@@H](CC(C)C)NC)O)Cl)CO)O)O)(C)N)O.Cl
PubChem CID	6420023
分子量	1485.71
Beilstein号	3704657

化学和物理性质

溶解性	Soluble in water. Slightly soluble in methanol, ethanol and dimethylsulfoxide.
敏感性	易吸潮
分子量	1485.700 g/mol
XLogP3
氢键供体数Hydrogen Bond Donor Count	20
氢键受体数Hydrogen Bond Acceptor Count	26
可旋转键计数Rotatable Bond Count	13
精确质量Exact Mass	1483.41 Da
单同位素质量Monoisotopic Mass	1483.41 Da
拓扑极表面积Topological Polar Surface Area	530.000 Å²
重原子数Heavy Atom Count	102
形式电荷Formal Charge	0
复杂度Complexity	2960.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	18
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	2

安全和危险性（GHS）

象形图	GHS07
信号词	危险
危险声明	H315: 引起皮肤刺激 H317: 可能引起皮肤过敏反应 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
预防措施声明	P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P272: 被污染的工作服不允许离开工作场所 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany	2
RTECS	YW4380000
个人防护装备	dust mask type N95 (US),Eyeshields,Faceshields,Gloves

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技术文档和文章

新型抗菌利器——抗菌肽

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多肽抗生素天然产物细胞生物学免疫学抗菌配体 WHO基本药物配体人内源性肽抗菌肽 RAMPs

此产品的引用文献

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引用文献

1. Hadeel Al-Kofide,Iman Zaghloul,Lamya Al-Naim. (2009-12-18) Pharmacokinetics of vancomycin in adult cancer patients.. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 16 ((4)): (245-250). [PMID:20015925]
2. Torsten S Boutrup,Kirsten Schauser,Jørgen S Agerholm,Tim K Jensen. (2010-02-26) Application of a pig ligated intestinal loop model for early Lawsonia intracellularis infection.. Acta veterinaria Scandinavica, 52 (17-17). [PMID:20181246]
3. Celine Vidaillac,Susana Gardete,Ryan Tewhey,George Sakoulas,Glenn W Kaatz,Warren E Rose,Alexander Tomasz,Michael J Rybak. (2013-03-30) Alternative mutational pathways to intermediate resistance to vancomycin in methicillin-resistant Staphylococcus aureus.. The Journal of infectious diseases, 208 ((1)): (67-74). [PMID:23539745]
4. Anisa D Patel,Dhullipala Anand,Carol Lucas,Alison H Thomson. (2013-04-02) Continuous infusion of vancomycin in neonates.. Archives of disease in childhood, 98 ((6)): (478-479). [PMID:23543265]
5. Helen M Sammons,Elizabeth Starkey. (2013-04-18) Vancomycin use in neonates and children: evidence-based practice is needed.. Archives of disease in childhood, 98 ((6)): (447-448). [PMID:23592728]
6. Joseph R Pinchman,Dale L Boger. (2013-04-27) Probing the role of the vancomycin e-ring aryl chloride: selective divergent synthesis and evaluation of alternatively substituted E-ring analogues.. Journal of medicinal chemistry, 56 ((10)): (4116-4124). [PMID:23617725]
7. B A Tantry,S Rahiman. (2013-04-30) Antibacterial resistance and trend of urinary tract pathogens to commonly used antibiotics in Kashmir Valley.. The West Indian medical journal, 61 ((7)): (703-707). [PMID:23620968]
8. Neelam Pushker,Lalit Kumar Tejwani,Mandeep S Bajaj,Saurbhi Khurana,Thirumurthy Velpandian,Mahesh Chandra. (2013-04-30) Role of oral corticosteroids in orbital cellulitis.. American journal of ophthalmology, 156 ((1)): (178-183). [PMID:23622565]
9. Elizabeth Cristina Gomes Dos Santos,Claudio Luis Donnici,Elizabeth Ribeiro da Silva Camargos,Adriana Augusto de Rezende,Eloisa Helena de Aguiar Andrade,Luiz Alberto Lira Soares,Luiz de Macêdo Farias,Maria Auxiliadora Roque de Carvalho,Maria das Graças Almeida. (2013-05-04) Effects of Copaifera duckei Dwyer oleoresin on the cell wall and cell division of Bacillus cereus.. Journal of medical microbiology, 62 ((Pt 7)): (1032-1037). [PMID:23639986]
10. R Strauss,M F Neurath. (2013-05-15) [Clostridium difficile infections - still a major challenge].. MMW Fortschritte der Medizin, 155 ((7)): (57-59). [PMID:23668179]
11. Laura Chang,David Cassarino,Valentina Sosa. (2013-05-17) Diffuse umbilicated vesicles in a critically ill child.. JAMA dermatology, 149 ((5)): (641-642). [PMID:23677115]
12. Jeremy Y Chan,Andrew J Elliott,Scott J Ellis. (2013-05-23) Reconstruction of achilles rerupture with peroneus longus tendon transfer.. Foot & ankle international, 34 ((6)): (898-903). [PMID:23696187]
13. Oliver A Cornely,Mark A Miller,Bruno Fantin,Kathleen Mullane,Yin Kean,Sherwood Gorbach. (2013-05-30) Resolution of Clostridium difficile-associated diarrhea in patients with cancer treated with fidaxomicin or vancomycin.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31 ((19)): (2493-2499). [PMID:23715579]
14. Els van Nood,Marcel G W Dijkgraaf,Josbert J Keller. (2013-05-31) Duodenal infusion of feces for recurrent Clostridium difficile.. The New England journal of medicine, 368 ((22)): (2145-2145). [PMID:23718168]
15. Bernhard Ramsauer. (2013-05-31) Duodenal infusion of feces for recurrent Clostridium difficile.. The New England journal of medicine, 368 ((22)): (2144-2144). [PMID:23718171]
16. Valentin Brodszky,László Gulácsi,Endre Ludwig,Gyula Prinz,János Banai,Péter Reményi,Bálint Strbák,Adrienne Kertész,Irén Kopcsóné Németh,Edit Zsoldiné Urbán,Petra Baji,Márta Péntek. (2013-06-04) [Antimicrobial therapy of Clostridium difficile infection. Systematic review and meta-analysis of the scientific evidence].. Orvosi hetilap, 154 ((23)): (890-899). [PMID:23728312]
17. Shahrzad Mohammadi,Kimberly MacKay,Thomas T Ward,Graeme N Forrest. (2013-06-06) Clinical outcomes of a veterans affairs outpatient antimicrobial treatment program.. Southern medical journal, 106 ((6)): (345-349). [PMID:23736174]
18. Jean Félix Piñerúa Gonsálvez,Rosanna del Carmen Zambrano Infantinot,Carlos Calcaño,César Montaño,Zaida Fuenmayor,Henry Rodney,Marianela Rodney. (2013-06-21) [Infective endocarditis by Rhizobium radiobacter. A case report].. Investigacion clinica, 54 ((1)): (68-73). [PMID:23781714]
19. V Anil Kumar. (2013-06-27) Laboratory detection of MRSA.. The new microbiologica, 36 ((2)): (207-207). [PMID:23798063]
20. S Awad,A E Alharbi,I Alshami. (2013-07-31) Exposure of vancomycin-sensitive Staphylococcus aureus to subinhibitory levels of vancomycin leads to upregulated capsular gene expression.. British journal of biomedical science, 70 ((2)): (58-61). [PMID:23888606]
21. Jop de Vrieze. (2013-08-31) Medical research. The promise of poop.. Science (New York, N.Y.), 341 ((6149)): (954-957). [PMID:23990540]
22. Javid Sadeghi,Shahla Mansouri. (2013-09-17) Molecular characterization and antibiotic resistance of clinical isolates of methicillin-resistant Staphylococcus aureus obtained from Southeast of Iran (Kerman).. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 122 ((5)): (405-411). [PMID:24033803]
23. Noel Prevost,Joseph C English. (2013-09-17) Candida rib osteomyelitis: erythema and nodule in midline scar.. Journal of the American Academy of Dermatology, 69 ((4)): (e205-e207). [PMID:24034406]
24. Kartik Sampath,L Campbell Levy,Timothy B Gardner. (2013-09-24) Fecal transplantation: beyond the aesthetic.. Gastroenterology, 145 ((5)): (1151-1153). [PMID:24055638]
25. Josbert J Keller. (2013-09-24) Reply: To PMID 23323867.. Gastroenterology, 145 ((5)): (1153-1153). [PMID:24055639]
26. Jennifer L Macisaac,Chloé E Ward,Melanie Pratt. (2013-10-22) Cutaneous T-cell lymphoma-like drug eruption in an HIV-positive patient taking vancomycin and rifampin.. Journal of cutaneous medicine and surgery, 17 ((6)): (433-436). [PMID:24138984]
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28. Philip Storey,Michael Dollin,John Pitcher,Sahitya Reddy,Joseph Vojtko,James Vander,Jason Hsu,Sunir J Garg. (2013-10-23) The role of topical antibiotic prophylaxis to prevent endophthalmitis after intravitreal injection.. Ophthalmology, 121 ((1)): (283-289). [PMID:24144453]
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30. Soheyla Honary,Pouneh Ebrahimi,Roja Hadianamrei. (2013-10-24) Optimization of particle size and encapsulation efficiency of vancomycin nanoparticles by response surface methodology.. Pharmaceutical development and technology, 19 ((8)): (987-998). [PMID:24147898]
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40. Christopher J Rudnisky,Darwin Wan,Ezekiel Weis. (2013-12-12) Antibiotic choice for the prophylaxis of post-cataract extraction endophthalmitis.. Ophthalmology, 121 ((4)): (835-841). [PMID:24326107]
41. Collins Njie Ateba,Kgothatso Pontsho Lekoma,David Tonderai Kawadza. (2013-12-18) Detection of vanA and vanB genes in vancomycin-resistant enterococci (VRE) from groundwater using multiplex PCR analysis.. Journal of water and health, 11 ((4)): (684-691). [PMID:24334842]
42. Lukas P Zebala,Tapanut Chuntarapas,Michael P Kelly,Michael Talcott,Suellen Greco,K Daniel Riew. (2014-01-03) Intrawound vancomycin powder eradicates surgical wound contamination: an in vivo rabbit study.. The Journal of bone and joint surgery. American volume, 96 ((1)): (46-51). [PMID:24382724]
43. Wessam Abdelhady,Arnold S Bayer,Kati Seidl,Derek E Moormeier,Kenneth W Bayles,Ambrose Cheung,Michael R Yeaman,Yan Q Xiong. (2014-01-10) Impact of vancomycin on sarA-mediated biofilm formation: role in persistent endovascular infections due to methicillin-resistant Staphylococcus aureus.. The Journal of infectious diseases, 209 ((8)): (1231-1240). [PMID:24403556]
44. Mathias Herrmann. (2014-01-10) Antimicrobial effects promoting biofilm formation and persistent disease: the role of a DNA-binding regulator, SarA, in staphylococcal endocarditis.. The Journal of infectious diseases, 209 ((8)): (1153-1155). [PMID:24403558]
45. Ajay E Kuriyan,Kathleen D Weiss,Harry W Flynn,William E Smiddy,Audina M Berrocal,Thomas A Albini,Darlene Miller. (2014-01-15) Endophthalmitis caused by streptococcal species: clinical settings, microbiology, management, and outcomes.. American journal of ophthalmology, 157 ((4)): (774-780). [PMID:24418264]
46. Aseem Arif Shaikh,Chul-Won Ha,Yong-Geun Park,Yong-Beom Park. (2014-03-07) Two-stage approach to primary TKA in infected arthritic knees using intraoperatively molded articulating cement spacers.. Clinical orthopaedics and related research, 472 ((7)): (2201-2207). [PMID:24599649]
47. M A Asencio,M Huertas,R Carranza,J M Tenias,J Celis,F Gonzalez-Del Valle. (2014-03-13) A case-control study of post-operative endophthalmitis diagnosed at a Spanish hospital over a 13-year-period.. Epidemiology and infection, 143 ((1)): (178-183). [PMID:24612657]
48. Alan S Boyd,Melanie Ortleb. (2014-03-19) Vancomycin-associated neutrophilic dermatitis histologically mimicking Cryptococcus.. Journal of the American Academy of Dermatology, 70 ((4)): (e86-e88). [PMID:24629371]
49. Robert A Waeiss,Thais C Negrini,Rodrigo A Arthur,Marco C Bottino. (2014-03-19) Antimicrobial effects of drug-containing electrospun matrices on osteomyelitis-associated pathogens.. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 72 ((7)): (1310-1319). [PMID:24630157]
50. Tina Manzhu Kang,Jessica Yuan,Alice Zhou,Casey Beppler,Jeffrey H Miller. (2014-03-19) Deoxycytidine deaminase-deficient Escherichia coli strains display acute sensitivity to cytidine, adenosine, and guanosine and increased sensitivity to a range of antibiotics, including vancomycin.. Journal of bacteriology, 196 ((11)): (1950-1957). [PMID:24633874]
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溶液计算器

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货号 (SKU)	包装规格	是否现货
V105495-250mg	250mg	现货
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V105495-5g	5g	现货
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V105495-100g	100g	现货

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溶液计算器

摩尔浓度计算器

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