| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| T648684-5mg |
5mg |
期货  |
| |
| T648684-10mg |
10mg |
期货 |
|
| 规格或纯度 | ≥99% |
|---|---|
| 英文名称 | T0467 |
| 生化机理 | T0467 在体外以 PINK1 依赖性方式激活 parkin 线粒体转运。T0467 不会诱导多巴胺能神经元中 PINK1 的线粒体积累。T0467 是一种潜在的 PINK1-Parkin 信号激活化合物，可用于 |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
T0467 activates parkin mitochondrial translocation in a PINK1-dependent manner in vitro. T0467 do not induce mitochondrial accumulation of PINK1in dopaminergic neurons. T0467 is a potential compound for PINK1-Parkin signaling activation, and can be used for parkinson's disease and related disorders research. In Vitro T0467 (2.5-20 μM; 3 hours) stimulates the mitochondrial translocation of GFP-Parkinover 12 μM in HeLa/GFP-Parkin cells. When HeLa/GFP-Parkin cells are treated with 20 μM T0467 for 3 h, GTP-Parkin is translocated to the mitochondria in approximately 21% of cells. T0467 does not show obvious toxicity in Drosophila at concentrations <50 μM. All cpds examined mitigated the PINK1 inactivation-mediated larval locomotion defects and mitochondrial morphological defects and reduced ATP production. T0467 and KTP improved the mitochondrial Ca 2+ response in Drosophila larval muscles. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid |
| 纯度 | ≥99% |
| Smiles | FC1=CC=C(CN2[C@H](CNCC2)C)C=C1C3=NC(NCCC4=CC(F)=CC(F)=C4)=NC=C3 |
|---|---|
| 分子量 | 441.49 |
| 溶解性 | DMSO : 33.33 mg/mL (75.49 mM; Need ultrasonic) |
|---|
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