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甲状腺球蛋白 来源于牛甲状腺

  • Accession #: P01267
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库存信息

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库存信息

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库存信息

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
T572842-10mg
10mg 现货 Stock Image
T572842-50mg
50mg 现货 Stock Image
T572842-100mg
100mg 现货 Stock Image
T572842-500mg
500mg 现货 Stock Image
T572842-1g
1g 现货 Stock Image

基本描述

产品名称 甲状腺球蛋白 来源于牛甲状腺
别名 甲状腺球蛋白(非重组)
英文别名 TG
规格或纯度 BioReagent, ≥95%(SDS-PAGE)
生化机理 Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling. Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream. One dimer produces 7 thyroid hormone molecules. Post-translational: Iodinated on tyrosine residues by TPO. There are 4 pairs of iodinated tyrosines used for coupling: acceptor Tyr-24 is coupled to donor Tyr-149 or Tyr-234, acceptor Tyr-2574 is coupled to donor Tyr-2541, acceptor Tyr-2767 in monomer 1 is coupled to donor Tyr-2767 in monomer 2 and acceptor Tyr-1310 in monomer 1 is coupled to donor Tyr-108 in monomer 2. Sulfated tyrosines are desulfated during iodination. Undergoes sequential proteolysis by cathepsins to release thyroxine (T4) and triiodothyronine (T3) hormones. In the thyroid follicle lumen, cross-linked TG (storage form) is solubilized by limited proteolysis mediated by cathepsins CTSB and/or CTSL. Partially cleaved TG is further processed by CTSK/cathepsin K and/or CTSL resulting in the release of T4. Following endocytosis, further processing occurs leading to the release of T3 and more T4 hormones.
产品介绍


  从牛甲状腺纯化的天然甲状腺球蛋白,由两个330 kDa的多肽同型二聚体组成。
处理说明
  溶解后,等分并冷冻保存(-20℃)。储备溶液在-20°C下可稳定保存1年。
产品应用
  用作生产抗体的载体蛋白,大量的酪氨酸残基可用于重氮反应进行偶联。

种属 牛(Bovine)
Accession # P01267
来源 天然
预测分子量 660 kDa

储存与运输

物理形态 冻干(Lyophilized)
储存温度 -20°C储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 长期储存-20℃(4年);复溶后建议分装,避免反复冻融。
CAS编号和信息 9010-34-8
分子类型 蛋白质

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找到5个结果

批号(Lot Number) 证书类型 货号
ZJ25F0927671 分析证书 T572842
ZJ25F0927664 分析证书 T572842
ZJ25F0927669 分析证书 T572842
ZJ25F0927670 分析证书 T572842
ZJ25F0927668 分析证书 T572842

溶液计算器