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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| T572842-10mg |
10mg |
现货 ![]() |
| |
| T572842-50mg |
50mg |
现货 ![]() |
| |
| T572842-100mg |
100mg |
现货 ![]() |
| |
| T572842-500mg |
500mg |
现货 ![]() |
| |
| T572842-1g |
1g |
现货 ![]() |
|
| 产品名称 | 甲状腺球蛋白 来源于牛甲状腺 |
|---|---|
| 别名 | 甲状腺球蛋白(非重组) |
| 英文别名 | TG |
| 规格或纯度 | BioReagent, ≥95%(SDS-PAGE) |
| 生化机理 | Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling. Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream. One dimer produces 7 thyroid hormone molecules. Post-translational: Iodinated on tyrosine residues by TPO. There are 4 pairs of iodinated tyrosines used for coupling: acceptor Tyr-24 is coupled to donor Tyr-149 or Tyr-234, acceptor Tyr-2574 is coupled to donor Tyr-2541, acceptor Tyr-2767 in monomer 1 is coupled to donor Tyr-2767 in monomer 2 and acceptor Tyr-1310 in monomer 1 is coupled to donor Tyr-108 in monomer 2. Sulfated tyrosines are desulfated during iodination. Undergoes sequential proteolysis by cathepsins to release thyroxine (T4) and triiodothyronine (T3) hormones. In the thyroid follicle lumen, cross-linked TG (storage form) is solubilized by limited proteolysis mediated by cathepsins CTSB and/or CTSL. Partially cleaved TG is further processed by CTSK/cathepsin K and/or CTSL resulting in the release of T4. Following endocytosis, further processing occurs leading to the release of T3 and more T4 hormones. |
| 产品介绍 |
从牛甲状腺纯化的天然甲状腺球蛋白,由两个330 kDa的多肽同型二聚体组成。 |
| 种属 | 牛(Bovine) |
| Accession # | P01267 |
| 来源 | 天然 |
| 预测分子量 | 660 kDa |
| 物理形态 | 冻干(Lyophilized) |
|---|---|
| 储存温度 | -20°C储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | 长期储存-20℃(4年);复溶后建议分装,避免反复冻融。 |
| CAS编号和信息 | 9010-34-8 |
| 分子类型 | 蛋白质 |
通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
| 分析证书 | T572842 | |
| 分析证书 | T572842 | |
| 分析证书 | T572842 | |
| 分析证书 | T572842 | |
| 分析证书 | T572842 |