| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| T407817-1ml |
1ml |
现货  |
|
| 英文别名 | Phenanthro[1,2-b]furan-10,11-dione, 1,6-dimethyl- |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Tanshinone I |
| 生化机理 | 丹参酮 I是从丹参中分离出来的一种活性成分，在结构上与丹参酮 IIA 相似，可能对肿瘤细胞具有类似的细胞毒性作用。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Tanshinone I is a pigment isolated from the herbal medicine Salvia miltiorrhiza Bunge. Tanshinone I displays cytotoxicity against human macrophages and IFN-g production in KLH-primed lymph node cells.A biochemical that displays cytotoxicity against IFN-g production in KLH-primed lymph node cells Information Tanshinone I Tanshinone I, an active principle isolated from Salvia miltiorrhiza (Danshen), is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells. Tanshinone I, an active principle isolated from Salvia miltiorrhiza (Danshen), is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells. Tanshinone I inhibits PGE2 formation from LPS-induced RAW macrophages (IC50 = 38 μM). However, this compound does not affect COX-2 activity or COX-2 expression. Tanshinone I is an inhibitor of type IIA human recombinant phospholipase A2 (PLA2) with IC50 of 11 μM. In preliminary data, tanshinone I possesses the strongest inhibitory effect on tumor necrosis factor-α (TNF-α)-induced adhesion molecules. In vivo
cell lines： Concentrations： Incubation Time： Powder Purity:≥95% |
| Isomeric SMILES | CC1=C2C=CC3=C(C2=CC=C1)C(=O)C(=O)C4=C3OC=C4C |
|---|---|
| PubChem CID | 114917 |
| 分子量 | 276.29 |
| 溶解性 | Solubility (25°C) In vitro |
|---|---|
| 折光率 | 1.68 |
| 沸点 | 474-522 °C |
| 熔点 | 233-234℃ |
| 危险声明 |
H413: 可能对水生生物造成长期的有害影响 |
|---|---|
| WGK Germany | 3 |
| 1. Qianqian Jiang, Xu Chen, Xue Tian, Jingmei Zhang, Siming Xue, Yanyan Jiang, Tiantian Liu, Xiaoping Wang, Qianbin Sun, Yiqin Hong, Chun Li, Dongqing Guo, Yong Wang, Qiyan Wang. (2022) Tanshinone I inhibits doxorubicin-induced cardiotoxicity by regulating Nrf2 signaling pathway. PHYTOMEDICINE, 106 (154439). [PMID:36108374] [10.1016/j.phymed.2022.154439] |
| 2. Shen Qing, Wang Haixing, Quan Bin, Sun Xiuhua, Wu Guohua, Huang Darong, Wang Qingcheng, Luo Pei. (2022) Rapid quantification of bioactive compounds in Salvia miltiorrhiza Bunge derived decoction pieces, dripping pill, injection, and tablets by polarity-switching UPLC-MS/MS. Frontiers in Chemistry, 10 [PMID:35910733] [10.3389/fchem.2022.964744] |
| 3. Changping Deng, Xiaolong Hao, Min Shi, Rong Fu, Yao Wang, Yi Zhang, Wei Zhou, Yue Feng, Nokwanda P. Makunga, Guoyin Kai. (2019) Tanshinone production could be increased by the expression of SmWRKY2 in Salvia miltiorrhiza hairy roots. PLANT SCIENCE, 284 (1). [PMID:31084862] [10.1016/j.plantsci.2019.03.007] |
| 4. Xu-Xin Zhang, Yun-Feng Cao, Li-Xuan Wang, Xiao-Lin Yuan, Zhong-Ze Fang. (2017) Inhibitory effects of tanshinones towards the catalytic activity of UDP-glucuronosyltransferases (UGTs). PHARMACEUTICAL BIOLOGY, [PMID:28466663] [10.3109/13880209.2015.1045621] |
| 5. Man Wang, Wentao Bi, Xiaohua Huang, David Da Yong Chen. (2016) Ball mill assisted rapid mechanochemical extraction method for natural products from plants. JOURNAL OF CHROMATOGRAPHY A, 1449 (8). [PMID:27157426] [10.1016/j.chroma.2016.04.044] |
| 6. Shi Min, Zhou Wei, Zhang Jianlin, Huang Shengxiong, Wang Huizhong, Kai Guoyin. (2016) Methyl jasmonate induction of tanshinone biosynthesis in Salvia miltiorrhiza hairy roots is mediated by JASMONATE ZIM-DOMAIN repressor proteins. Scientific Reports, 6 (1): (1-11). [PMID:26875847] [10.1038/srep20919] |
| 7. Min Shi, Xiuqin Luo, Guanhua Ju, Leilei Li, Shengxiong Huang, Tong Zhang, Huizhong Wang, Guoyin Kai. (2016) Enhanced Diterpene Tanshinone Accumulation and Bioactivity of Transgenic Salvia miltiorrhiza Hairy Roots by Pathway Engineering. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 64 (12): (2523–2530). [PMID:26753746] [10.1021/acs.jafc.5b04697] |
| 8. Chenchen Zhang, Shan Jiang, Kun Li, Mei Wang, Rongrong Zhu, Xiaoyu Sun, Qingxiu Wang, ShiLong Wang. (2015) The triplet state of tanshinone I and its synergic effect on the phototherapy of cancer cells with curcumin. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 150 (181). [PMID:26046496] [10.1016/j.saa.2015.05.062] |
| 9. Jinghui Li, Yan Kang, Ying Wang, Jiaxin Liu, Yingting Wang, Sitong Liu, Yunxi Bu, Xiangqun Li, Jiahan Xie, Zhibing Wang. (2025) Ionic Liquid-Based Polarity-Adjustable Deep Eutectic Solvent Extraction Followed by High-Performance Liquid Chromatography-Diode-Array Detection for the Determination of Liposoluble Anthraquinones in Salvia miltiorrhiza Bge. Root. JOURNAL OF SEPARATION SCIENCE, 48 (3): (e70116). [PMID:40057467] [10.1002/jssc.70116] |
| 10. Shaoping Ma, Changyong Cai, Xuhong Guo, Zhijian Tan. (2025) Selective separation of tanshinone homologs by biocomposite membranes based on poly(ionic liquids) and natural fibers. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 295 (139568). [PMID:39793843] [10.1016/j.ijbiomac.2025.139568] |
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