ST-193 hydrochloride

COA

级别和纯度:

≥98%

CAS编号: 2320274-72-2
分子式: C₂₄H₂₆ClN₃O
分子量: 407.94

有货

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货号 (SKU)	包装规格	是否现货
S651361-5mg	5mg	期货
S651361-10mg	10mg	期货
S651361-25mg	25mg	期货
S651361-50mg	50mg	期货
S651361-100mg	100mg	期货

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Anti-infection (2804) Arenavirus (22) Virus (3767)

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基本描述

别名	ST-193盐酸盐
规格或纯度	≥98%
英文名称	ST-193 hydrochloride
生化机理	ST-193 盐酸盐是一种强效的广谱arenavirus 抑制剂；对 Guanarito、Junin、Lassa 和 Machupo 病毒的抑制作用 IC 50 值分别为 0.44、0.62、1.4 和 3.1 nM。
储存温度	2-8°C储存,干燥
运输条件	冰袋运输
产品介绍	ST-193 hydrochloride is a potent broad-spectrum arenavirus inhibitor; inhibits Guanarito, Junin, Lassa and Machupo virus with IC 50 values of 0.44, 0.62, 1.4 and 3.1 nM, respectively. In Vitro ST-193 inhibits LASV pseudotypes with an IC 50 of 1.6 nM. ST-193 inhibits pseudotypes generated with other arenavirus envelopes as well, including the remaining four commonly associated with hemorrhagic fever (IC 50 s for Junín, Machupo, Guanarito, and Sabiá are in the 0.2 to 12 nM range) but exhibits no antiviral activity against pseudotypes incorporating either the GP from the LASV-related arenavirus lymphocytic choriomeningitis virus or the unrelated G protein from vesicular stomatitis virus, at concentrations of up to 10 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo ST-193 is found to be tolerated well when administered daily as an intraperitoneal injection of either 25 or 100 mg/kg/day for 14 days. ST-193-treated animals exhibit fewer signs of disease and enhance survival when compared to the ribavirin or vehicle groups. Body temperatures in all groups are elevated by day 9, but returned to normal by day 19 postinfection in the majority of ST-193-treated animals. ST-193 treatment mediates a 2- to 3-log reduction in viremia relative to vehicle-treated controls. The overall survival rate for the ST-193-treated guinea pigs is 62.5% (10/16) compared with 0% in the ribavirin (0/8) and vehicle (0/7) groups. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 0.44 nM (Guanarito), 0.62 nM (Junin), 1.4 nM (Lassa) and 3.1 nM (Machupo)
纯度	≥98%

名称和识别符

Smiles	CC(C1=CC=C(CNC2=CC=C3C(N=CN3C4=CC=C(OC)C=C4)=C2)C=C1)C.[H]Cl
分子量	407.94

化学和物理性质

溶解性	DMSO : ≥ 150 mg/mL (367.70 mM) H2O : <0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

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