SKF-34288 hydrochloride

COA

级别和纯度:

≥95%

CAS编号: 320386-54-7
分子式: C₆H₆ClNO₂S
分子量: 191.64
PubChem编号: 24721311

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货号 (SKU)	包装规格	是否现货
S650474-1mg	1mg	期货
S650474-5mg	5mg	期货
S650474-10mg	10mg	期货

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Glucose Metabolism (3713) Metabolic Enzyme/Protease (4889) PEPCK (4)

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基本描述

别名	SKF-34288 盐酸盐
英文别名	FT-0671101 \| 3-sulfanylpyridine-2-carboxylic acid;hydrochloride \| AS-79457 \| D94966 \| AKOS027321159 \| SKF-34288 hydrochloride \| A904188 \| HY-128923 \| SKF-34288 (hydrochloride) \| 3-Mercaptopicolinic acid (hydrochloride) \| J-018609 \| 3-Mercaptopicolinic Aci
规格或纯度	≥95%
英文名称	SKF-34288 hydrochloride
生化机理	SKF-34288（3-巯基吡啶甲酸）盐酸盐是一种口服活性磷酸烯醇丙酮酸羧激酶（PEPCK）抑制剂（K i : 2-9 μM）。SKF-34288 盐酸盐可抑制葡萄糖合成，是一种强效降血糖药。SKF-34288 盐酸盐 a
储存温度	-20°C储存,干燥
运输条件	超低温冰袋运输
产品介绍	SKF-34288 (3-Mercaptopicolinic acid) hydrochloride is an orally active phosphoenolpyruvate carboxykinase ( PEPCK ) inhibitor ( K i : 2-9 μM). SKF-34288 hydrochloride is a potent hypoglycemic agent by inhibiting glucose synthesis. SKF-34288 hydrochloride also inhibits Asn metabolism and increases amino acids and amides In Vitro SKF-34288 hydrochloride (0.01-1 mM, 48 h) inhibits C2C12 cell proliferation . SKF-34288 hydrochloride (0.25-1 mM, 0-5 day) induces myogenic differentiation of C2C12 cells . SKF-34288 hydrochloride (0.25 or 1 mM) reduces mRNA expression of Pck2 and genes associated with serine biosynthesis . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay Cell Line: C2C12 cell Concentration: 0, 0.01, 0.1, 0.25, 0.5, 1 mM Incubation Time: 48 h Result: Dose-dependently inhibited C2C12 cell proliferation. In Vivo SKF-34288 hydrochloride (37.5-150mg/kg, p.o.) reduces blood glucose in starved rats . SKF-34288 hydrochloride (25 mg/kg, s.c.) neutralizes Salbutamol- mediated hyperglycaemia in rabbits. SKF-34288 hydrochloride (30 and 300 mg/kg, i.p.) reduces Pyruvate-induced blood glucose level in rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Starved rats Dosage: 37.5, 75 and 150mg/kg Administration: Oral administration (p.o.) Result: Showed dose-dependent magnitude and duration of the hypoglycaemic effect. Form:Solid IC50& Target:Ki: 2-9 μM (PEPCK)
纯度	≥95%

名称和识别符

IIUPAC Name	3-sulfanylpyridine-2-carboxylic acid;hydrochloride
INCHI	1S/C6H5NO2S.ClH/c8-6(9)5-4(10)2-1-3-7-5;/h1-3,10H,(H,8,9);1H
InChi Key	DYGYEUUVNLEHJP-UHFFFAOYSA-N
Smiles	C1=CC(=C(N=C1)C(=O)O)S.Cl
Isomeric SMILES	C1=CC(=C(N=C1)C(=O)O)S.Cl
PubChem CID	24721311
分子量	191.64

化学和物理性质

溶解性	H2O : 5 mg/mL (26.09 mM; Need ultrasonic)
分子量	191.640 g/mol
XLogP3
氢键供体数Hydrogen Bond Donor Count	3
氢键受体数Hydrogen Bond Acceptor Count	4
可旋转键计数Rotatable Bond Count	1
精确质量Exact Mass	190.981 Da
单同位素质量Monoisotopic Mass	190.981 Da
拓扑极表面积Topological Polar Surface Area	51.200 Å²
重原子数Heavy Atom Count	11
形式电荷Formal Charge	0
复杂度Complexity	140.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	2

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