SRI-42127

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货号 (SKU)	包装规格	是否现货
S649484-5mg	5mg	期货
S649484-10mg	10mg	期货
S649484-25mg	25mg	期货
S649484-50mg	50mg	期货

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基本描述

规格或纯度	≥99%
英文名称	SRI-42127
生化机理	SRI-42127 是一种 HuR 易位抑制剂。HuR 是一种与 AREs 结合的 RNA 调节器，HuR 易位可促进神经胶质细胞中炎性细胞因子的产生。然而，SRI-42127 可破坏 mRNA 的稳定性并抑制基因启动子的激活。
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	SRI-42127 is a HuR translocation inhibitor. HuR is an RNA regulator that binds to AREs, and HuR translocations promote the production of inflammatory cytokines in glial cells. However, SRI-42127 can destroy mRNA stability and inhibit gene promoter activation. SRI-42127 also inhibits microglial cell activation and attenuates recruitment/chemotaxis of neutrophils and monocytes In Vitro SRI-42127 (0.05-1 μM; 24 h) blocks HuR cytoplasmic translocation stimulated by LPS (1 μg/mL) in primary microglia. SRI-42127 (0.05-1 μM; 24 h) suppresses inflammatory cytokine and chemokine mRNA in activated Primary microglia cells (PMG). SRI-42127 (0.5 μM and 1 μM; 24 h) blocks glial-produced chemoattraction/migration signals for neutrophils and monocytes. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo SRI-42127 (15 mg/kg; i.p.; single dose) suppresses HuR translocation and the activation of microglia in mice model . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:HuR
纯度	≥99%

名称和识别符

Smiles	CN(C1CCOCC1)C2=NN3C(C=C2)=NC=C3C4=CC5=C(C=C4)C=NN5
分子量	348.40

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