SRT3025盐酸

SIRT1 选择性抑制剂 | 活化剂 | 调节剂

COA

级别和纯度:

≥99%

CAS编号: 2070015-26-6
分子式: C₃₁H₃₁N₅O₂S₂.HCl
分子量: 606.2
PubChem编号: 118986647

有货

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库存信息

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库存信息

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货号 (SKU)	包装规格	是否现货
S414022-5mg	5mg	期货
S414022-25mg	25mg	期货
S414022-50mg	50mg	现货

查看相关系列

Cell Cycle (7376) Cell Cycle/DNA Damage (2603) Histone Modification (3105) Sirtuin (94) 表观遗传学 (1497)

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基本描述

英文别名	4-Thiazolecarboxamide,5-(3-methoxypropyl)-2-phenyl-N-[2-[6-(1-pyrrolidinylmethyl)thiazolo[5,4-b]pyridin-2-yl]phenyl]-,hydrochloride (1:1)
规格或纯度	≥99%
英文名称	SRT3025 HCl
生化机理	SRT3025 是一种可口服的 SIRT1 酶小分子激活剂。
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	Information SRT3025 is an orally available small molecule activator of theSIRT1enzyme. Targets SIRT1 (Cell-free assay) In vitro SRT3025 inhibits RANKL-induced osteoclast differentiation, fusion and resorptive capacity without affecting osteoclast survival. SRT3025 inhibits RANKL-induced osteoclastogenesis in bone marrow-derived macrophages (BMMs) by activating AMPK and deacetylating RelA/p65 lysine 310, critical for activation of the NF-κB signaling pathway. SRT3025 acts faster than oxymetholone to improve hematopoiesis. It does not work by direct activation of Sirt1 in hematopoietic cells. SRT3025 might suppress p21 transcription through the down-regulation of Egr1. SRT3025 is found to activate wild-type Sirt1 protein but failed to activate the E230K mutant, an activation-resistant Sirt1 protein (due to a mutation at position 230). In vivo SRT3025 treatment also inhibits tumor growth in Panc-1 xenografts, even though it is not as effective in inhibiting the viability of Panc-1 cells in culture. SRT3025 is well tolerated in mice and has the potential to be used in several diseases. SRT3025 administration expands HSPCs and boosts blood counts while long term SRT3025 administration does not permanently increase or decrease HSC repopulating potential. SRT3025 reduces plasma cholesterol, inflammation, and atherosclerosis in Apoe−/− mice, and it increases hepatic Ldlr expression and Pcsk9 accumulation. Cell Research(from reference) Cell lines：HPDE, Panc-1, SU86.86, Patu8988t cells Concentrations：0-5 μM Incubation Time：72 h
纯度	≥99%

产品属性

ALogP	5.849
HBD Count	1
Rotatable Bond	10

名称和识别符

IIUPAC Name	5-(3-methoxypropyl)-2-phenyl-N-[2-[6-(pyrrolidin-1-ylmethyl)-[1,3]thiazolo[5,4-b]pyridin-2-yl]phenyl]-1,3-thiazole-4-carboxamide;hydrochloride
INCHI	1S/C31H31N5O2S2.ClH/c1-38-17-9-14-26-27(35-29(39-26)22-10-3-2-4-11-22)28(37)33-24-13-6-5-12-23(24)30-34-25-18-21(19-32-31(25)40-30)20-36-15-7-8-16-36;/h2-6,10-13,18-19H,7-9,14-17,20H2,1H3,(H,33,37);1H
InChi Key	LGRBDTOIPNDWMN-UHFFFAOYSA-N
Smiles	COCCCC1=C(N=C(S1)C2=CC=CC=C2)C(=O)NC3=CC=CC=C3C4=NC5=C(S4)N=CC(=C5)CN6CCCC6.Cl
PubChem CID	118986647
分子量	606.2

化学和物理性质

溶解性	Solubility (25°C) In vitro DMSO: 100 mg/mL warmed with 50ºC Water: bath (164.96 mM); Ethanol: 5 mg/mL warmed with 50ºC Water: bath (8.24 mM); Water: Insoluble;
敏感性	对湿度敏感
DMSO(mg / mL) Max Solubility	100
DMSO(mM) Max Solubility	164.9620587
Water(mg / mL) Max Solubility	＜1
分子量	606.200 g/mol
XLogP3
氢键供体数Hydrogen Bond Donor Count	2
氢键受体数Hydrogen Bond Acceptor Count	8
可旋转键计数Rotatable Bond Count	10
精确质量Exact Mass	605.169 Da
单同位素质量Monoisotopic Mass	605.169 Da
拓扑极表面积Topological Polar Surface Area	137.000 Å²
重原子数Heavy Atom Count	41
形式电荷Formal Charge	0
复杂度Complexity	811.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	2

安全和危险性（GHS）

象形图	GHS07
信号词	警告
危险声明	H302: 吞食有害 H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
预防措施声明	P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。