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SPDP (3- [2-吡啶基二硫代]琥珀酰亚胺基丙酸酯)

SPDP (3- [2-吡啶基二硫代]琥珀酰亚胺基丙酸酯)

8篇引用文献

COA

级别和纯度:

≥95%

CAS编号: 68181-17-9
分子式: C₁₂H₁₂N₂O₄S₂
分子量: 312.36
PubChem编号: 100682

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货号 (SKU)	包装规格	是否现货
S164298-25mg	25mg	现货
S164298-100mg	100mg	期货
S164298-500mg	500mg	现货
S164298-1g	1g	现货
S164298-5g	5g	现货

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ADC Linker (354) Antibody-drug Conjugate/ADC Related (549)

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基本描述

别名	3-(2-吡啶基二硫基)丙酸N-羟基琥珀酰亚胺酯
英文别名	(SPDP);N-Succinimidyl 3-[2-pyridyldithio]propionate \| 1-(1-Oxo-3-(2-pyridyldithio)propoxy)pyrrolidine-2,5-dione \| 2,5-Pyrrolidinedione, 1-(1-oxo-3-(2-pyridinyldithio)propoxy)- \| SPDP (2mg*5) \| 3-(2-Pyridyldithio)propionic Acid N-Succinimidyl Ester \| 3-(Py
规格或纯度	≥95%
英文名称	SPDP (Succinimidyl 3-[2-pyridyldithio] propionate)
储存温度	-20°C储存,充氩
运输条件	超低温冰袋运输
产品介绍	SPDP crosslinker, N-Succinimidyl 3-(2-pyridyldithio) propionic acid, also called N-succinimidyl 3-(2-pyridyldithio)-propionate, or OPSS-NHS, is a short-length crosslinker for amine to sulfhydryl (thiol) conjμgation via its NHS-ester and pyridyldithiol reactive groups that form cleavable disulfide bonds with free thiol groups. Nanocs LC-SPDP is a long-length crossliker for amine to sulfhydryl conjμgation via its NHS-ester and pyridyldithiol reactive groups that form cleavable disulfide bonds with free thiol groups.3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) is useful for the preparation of enzyme immunoconjμgates and hapten carrier molecule conjμgates. It has been used for antibody conjμgation and as a protein cross-linker. SPDP crosslinker, N-Succinimidyl 3-(2-pyridyldithio) propionic acid, also called N-succinimidyl 3-(2-pyridyldithio)-propionate, or OPSS-NHS, is a short-length crosslinker for amine to sulfhydryl (thiol) conjugation via its NHS-ester and pyridyldithiol reactive groups that form cleavable disulfide bonds with free thiol groups. Nanocs LC-SPDP is a long-length crossliker for amine to sulfhydryl conjugation via its NHS-ester and pyridyldithiol reactive groups that form cleavable disulfide bonds with free thiol groups. 3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) is useful for the preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. It has been used for antibody conjugation and as a protein cross-linker.
纯度	≥95%

名称和识别符

IIUPAC Name	(2,5-dioxopyrrolidin-1-yl) 3-(pyridin-2-yldisulfanyl)propanoate
INCHI	1S/C12H12N2O4S2/c15-10-4-5-11(16)14(10)18-12(17)6-8-19-20-9-3-1-2-7-13-9/h1-3,7H,4-6,8H2
InChi Key	JWDFQMWEFLOOED-UHFFFAOYSA-N
Smiles	C1CC(=O)N(C1=O)OC(=O)CCSSC2=CC=CC=N2
Isomeric SMILES	C1CC(=O)N(C1=O)OC(=O)CCSSC2=CC=CC=N2
PubChem CID	100682
分子量	312.36

化学和物理性质

溶解性	acetone: 50 mg/mL；DMF: soluble
敏感性	对热敏感 ;对光线敏感 ;对湿度敏感
熔点	84-86°C
分子量	312.400 g/mol
XLogP3	0.700
氢键供体数Hydrogen Bond Donor Count	0
氢键受体数Hydrogen Bond Acceptor Count	7
可旋转键计数Rotatable Bond Count	7
精确质量Exact Mass	312.024 Da
单同位素质量Monoisotopic Mass	312.024 Da
拓扑极表面积Topological Polar Surface Area	127.000 Å²
重原子数Heavy Atom Count	20
形式电荷Formal Charge	0
复杂度Complexity	376.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

象形图	GHS07
信号词	警告

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找到12个结果

批号(Lot Number)	证书类型	货号
J2514060	分析证书	S164298
A2205491	分析证书	S164298
L2425296	分析证书	S164298
K2428100	分析证书	S164298
K2222680	分析证书	S164298
K2222770	分析证书	S164298
K2222778	分析证书	S164298
K2222846	分析证书	S164298
A2205493	分析证书	S164298
K2006065	分析证书	S164298
K2006064	分析证书	S164298
F2220029	分析证书	S164298

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引用文献

1. Lingli Jin, Fengjiao Chen, Xianwu Chen, Shun Zhang, Zhenjiang Liang, Lingling Zhao, Hui Tan. (2023) pH/Temperature Dual-Responsive Protein–Polymer Conjugates for Potential Therapeutic Hypothermia in Ischemic Stroke. ACS Applied Bio Materials, 6 (11): (5105–5113). [PMID:37903779] [10.1021/acsabm.3c00836]
2. Qianhong Su, Zuwei Liu, Ruolin Du, Xiaolu Chen, Longlong Chen, Zhaoming Fu, Xingyu Luo, Yong Yang, Xuequn Shi. (2023) Facile preparation of a metal-phenolic network-based lymph node targeting nanovaccine for antitumor immunotherapy. Acta Biomaterialia, 158 (510). [PMID:36603733] [10.1016/j.actbio.2022.12.066]
3. Yonghong Fan, Juan Pei, Xinxin Li, Yinhua Qin, Youqian Xu, Ming Ke, Jie Zhang, Yong Liu, Ju Tan, Mingcan Yang, Gang Li, Tianqing Li, Chuhong Zhu. (2023) Construction of tissue-engineered vascular grafts with high patency by mimicking immune stealth and blocking TGF-β mediated endothelial-to-mesenchymal transition. COMPOSITES PART B-ENGINEERING, 251 (110487). [10.1016/j.compositesb.2022.110487]
4. Chunhong Mo, Zhao Wang, Jianying Yang, Yiqiang Ouyang, Qian Mo, Shuting Li, Ping He, Limin Chen, Xinchun Li. (2022) Rational assembly of RGD/MoS2/Doxorubicin nanodrug for targeted drug delivery, GSH-stimulus release and chemo-photothermal synergistic antitumor activity. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 233 (112487). [PMID:35679748] [10.1016/j.jphotobiol.2022.112487]
5. Cailing Jiang, Feixiang Huang, Yi Chen, Li Jiang. (2021) Highly uniform self-assembled monolayers of silver nanospheres for the sensitive and quantitative detection of glutathione by SERS. DALTON TRANSACTIONS, 50 (30): (10436-10445). [PMID:34251012] [10.1039/D1DT01474A]
6. Yi-Ping Cao, Gao-Ying Zhi, Li Han, Queting Chen, Dong-Hao Zhang. (2021) Biosynthesis of benzyl cinnamate using an efficient immobilized lipase entrapped in nano-molecular cages. FOOD CHEMISTRY, 364 (130428). [PMID:34182366] [10.1016/j.foodchem.2021.130428]
7. Huiying Chen, Xuefeng Fan, Yinan Zhao, Defu Zhi, Shaohui Cui, Enxia Zhang, Haoming Lan, Jianjun Du, Zhen Zhang, Shubiao Zhang, Yuhong Zhen. (2020) Stimuli-Responsive Polysaccharide Enveloped Liposome for Targeting and Penetrating Delivery of survivin-shRNA into Breast Tumor. ACS Applied Materials & Interfaces, 12 (19): (22074–22087). [PMID:32083833] [10.1021/acsami.9b22440]
8. Jie Li, Yufeng Gu, Wenwen Sun, Baoyu Wen, Bin Li, Jie Liu, Zhihong Sun, Qi Zhao, Chengming Sun. (2024) Dual-Blocked Immune Checkpoint-Engineered Nanocarriers Combined with Photodynamic Therapy To Enhance Immunotherapy of Breast Cancer. ACS Applied Nano Materials, 7 (23): (27476-27488). [10.1021/acsanm.4c05465]

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SPDP (3- [2-吡啶基二硫代]琥珀酰亚胺基丙酸酯)

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基本描述

名称和识别符

化学和物理性质

安全和危险性（GHS）

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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此产品的引用文献

引用文献

溶液计算器

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