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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| rp218438-10μg |
10μg |
现货 ![]() |
| |
| rp218438-50μg |
50μg |
现货 ![]() |
| |
| rp218438-100μg |
100μg |
现货 ![]() |
| |
| rp218438-1mg |
1mg |
现货 ![]() |
|
| 产品名称 | Recombinant Human EMR1 Protein |
|---|---|
| 别名 | 重组人EMR1蛋白 | 重组人黏附G蛋白偶联受体E1 |
| 英文别名 | Adhesion G protein-coupled receptor E1 | EGF-like module receptor 1 | EGF-like module-containing mucin-like hormone receptor-like 1 | EMR1 hormone receptor | ADGRE1 | EMR1 | TM7LN3 |
| 规格或纯度 | 无载体, ≥85%(SDS-PAGE), 见COA |
| 生化机理 | Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development. |
| 内毒素水平 | <1.0 EU/μg |
| 表达系统 | E. coli |
| 种属 | 人(Human) |
| 氨基酸 | 430-596 aa |
| 序列 | MHHHHHHTEYLDIESKVINKECSEENVTLDLVAKGDKMKIGCSTIEESESTETTGVAFVSFVGMESVLNERFFKDHQAPLTTSEIKLKMNSRVVGGIMTGEKKDGFSDPIIYTLENIQPKQKFERPICVSWSTDVKGGRWTSFGCVILEASETYTICSCNQMANLAVIMASGEL |
| 蛋白标签 | N-His |
| 无载体 | Yes |
| 无动物源 | No |
| Accession # | Q14246 |
| 来源 | 重组表达 |
| 预测分子量 | 19.4 kDa |
| SDS-PAGE | 19.1 kDa, under reducing conditions; 18.2 & 36.5 & 55.8 kDa, under non-reducing conditions. |
| 物理形态 | 冻干(Lyophilized) |
|---|---|
| 储存缓冲液 | Lyophilized from 20mM Tris, 500mM NaCl, 8M Urea, 108 mM Imidazole, pH 8.0 |
| 浓度 | 见COA |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions. |
| 储存温度 | -20°C储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | -20℃保存 12个月;复溶后建议分装,避免反复冻融。 |
| 分子类型 | 蛋白质 |
Recombinant Human EMR1 Protein (rp218438) - SDS-PAGE
2 μg/lane of Recombinant Human EMR1 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 19.1 kDa under reducing conditions and 18.2 & 36.5 & 55.8 kDa under non-reducing conditions.
The GAIN-B domain and GPS orchestrate the activity of EMR1/ADGRE1 via a dual mechanism: stabilizing a self-inhibited conformation (resting state) to suppress basal signaling and enabling ligand- or force-dependent conformational transitions (activated state) to initiate downstream pathways (PMID: 34282836; PMID: 7601460).
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
| 分析证书 | rp218438 | |
| 分析证书 | rp218438 | |
| 分析证书 | rp218438 | |
| 分析证书 | rp218438 |