Recombinant Human JAK1 Protein

COA

级别和纯度:

无载体

≥80%(SDS-PAGE)
见COA

表达系统: E. coli
Accession #: P23458
蛋白标签: N-His
内毒素水平: <1.0 EU/μg

有货

库存信息

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库存信息

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库存信息

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货号 (SKU)	包装规格	是否现货
rp217131-10μg	10μg	现货
rp217131-100μg	100μg	现货
rp217131-1mg	1mg	期货

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点击查看蛋白信息: JAK1

Accession#:P23458 (2) Gene ID:3716 (2) JAK1 (2)

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基本描述

产品名称	Recombinant Human JAK1 Protein
别名	重组人JAK1蛋白 \| 重组人非受体酪氨酸激酶蛋白
英文别名	JAK 1 \| JAK 1A \| JAK 1B \| JAK-1 \| JAK1 \| JAK1_HUMAN \| JAK1A \| JAK1B \| Janus kinase 1 \| Janus kinase 1 (a protein tyrosine kinase) \| JTK3 \| Tyrosine protein kinase JAK 1 \| Tyrosine protein kinase JAK1 \| Tyrosine-protein kinase JAK1
规格或纯度	无载体, ≥80%(SDS-PAGE), 见COA
生化机理	Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway(PubMed:16239216, PubMed:28111307, PubMed:32750333, PubMed:7615558, PubMed:8232552). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952). Kinase partner for the type I interferon receptor IFNAR2 (PubMed:16239216, PubMed:28111307, PubMed:32750333, PubMed:7615558, PubMed:8232552). In response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins (PubMed:7759950). Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors (PubMed:16239216, PubMed:32750333, PubMed:8232552). Post-translational: Autophosphorylated (PubMed:7615558). Phosphorylated by TYK2 on tyrosine residues in response to type-I interferon signaling, leading to its activation (PubMed:8232552). Phosphorylated on tyrosine residues in response to interferon gamma signaling (PubMed:7615558). Dephosphorylation of Tyr-1034 and Tyr-1035 by PTPN2 negatively regulates cytokine-mediated signaling (PubMed:11909529). Ubiquitinated by RNF125; leading to its degradation by the proteasome.
内毒素水平	<1.0 EU/μg
表达系统	E. coli
种属	人(Human)
氨基酸	32-286 aa
序列	MHHHHHHPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIF
蛋白标签	N-His
无载体	Yes
无动物源	No
Accession #	P23458
来源	重组表达
预测分子量	30.7 kDa
SDS-PAGE	28.2 kDa, under reducing conditions

储存与运输

物理形态	冻干(Lyophilized)
储存缓冲液	Lyophilized from 20mM Tris, 500mM NaCl, 8M Urea, 500mM Imidazole, pH 8.0
浓度	见COA
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	-20℃保存 12个月；复溶后建议分装，避免反复冻融。

图片

SDS-PAGE: Recombinant Human JAK1 Protein (rp217131)

Recombinant Human JAK1 Protein (rp217131) - SDS-PAGE
2 μg/lane of Recombinant Human JAK1 Protein was resolved with SDS-PAGE under reducing (R) and visualized by Coomassie® Blue staining, showing a band at 28.2 kDa under reducing conditions.

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批号(Lot Number)	证书类型	货号
ZJ25F0623156	分析证书	rp217131
ZJ25F0623155	分析证书	rp217131

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