Recombinant Human GIPR Protein

COA

级别和纯度:

无动物源

无载体

≥95%(SDS-PAGE)
见COA

表达系统: HEK293
Accession #: P48546
蛋白标签: C-His
生物活性: Testing in progress
内毒素水平: <1.0 EU/μg

有货

库存信息

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货号 (SKU)	包装规格	是否现货
rp188259-10μg	10μg	现货
rp188259-50μg	50μg	现货
rp188259-100μg	100μg	现货
rp188259-1mg	1mg	期货

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点击查看蛋白信息: GIPR

Accession#: P48546 (1) Gene ID: 2696 (1) GIPR (1)

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基本描述

产品名称	Recombinant Human GIPR Protein
别名	重组人GIPR蛋白 \| 重组人胃抑制多肽受体蛋白
英文别名	gastric inhibitory polypeptide receptor \| GIPR \| GIP-R \| Glucose-dependent insulinotropic polypeptide receptor \| MGC126722 \| PGQTL2
规格或纯度	无动物源, 无载体, ≥95%(SDS-PAGE), 见COA
生化机理	Human Gastric Inhibitory Polypeptide Receptor (GIPR) is a transmembrane G protein coupled receptor that is mainly found in beta-cells within the pancreas. GIPR has 117 aa extracellular domain on its N-terminus, a central region consisting of seven transmembrane domains and a 68 aa C-terminal cytoplasmic domain that is responsible for intracellular transduction with the G-Protein. GIPR has three known isoforms produced by alternative splicing. The extracellular domain of human GIPR shows 76.3% and 81.2% amino acid identity with mouse and rat homolog, respectively. When originally discovered, GIPR was thought to have a role of inhibiting the secretion of gastrin and gastric acid. However, it was subsequently discovered that GIPR's main function was to stimulate the release of insulin in the presence of elevated blood glucose levels. GIPR has been found to bind to glucagon-like peptide-1 (GIP) and cascades downstream to release insulin. GIP and its receptor (GIPR) are of high pharmacological interest, since expression of GIPR are found in different organs and systems, especially in identification and design of new molecules for the treatment of diabetes mellitus and obesity. GIPR has also been shown to have an indirect relation with bone health and density. Mouse overexpressing GIP and GIPR had increased levels of osteoblasts and an overall decrease in age-related bone loss, while mice with GIPR knockout showed a decrease in overall bone mass and a higher level of compromised bone mass. Targeted Radionuclide Therapy (TRT) against GIPR positive cancer cells showed a significant increase of cell cycle arrest, specifically at the G2 and M phase, along with extensive DNA damage. Post-translational: N-glycosylation is required for cell surface expression and lengthens receptor half-life by preventing degradation in the ER.
生物活性	Testing in progress
内毒素水平	<1.0 EU/μg
表达系统	HEK293
种属	人(Human)
氨基酸	1-138 aa
序列	MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLACNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCENPEKNEAFLDQRLILERLQHHHHHH
蛋白标签	C-His
无载体	Yes
无动物源	Yes
Accession #	P48546
来源	重组表达
预测分子量	14.3 kDa
SDS-PAGE	22.1-32.4 kDa, under reducing conditions; 20.5-30.9 kDa, under non-reducing conditions.

储存与运输

物理形态	冻干(Lyophilized)
储存缓冲液	Lyophilized from PBS, pH 7.4.
浓度	见COA
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 0.5 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Store at -20°C for 1 year. Avoid freeze/thaw cycle.
分子类型	蛋白质

图片

SDS-PAGE: Recombinant Human GIPR Protein (rp188259)

Recombinant Human GIPR Protein (rp188259) - SDS-PAGE
3 μg/lane of Recombinant Human GIPR Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 22.1-32.4 kDa under reducing conditions and 20.5-30.9 kDa under non-reducing conditions.

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批号(Lot Number)	证书类型	货号
ZJ25F0218681	分析证书	rp188259
ZJ25F0218680	分析证书	rp188259
ZJ25F0218679	分析证书	rp188259

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