Recombinant Mouse IL-36Ra/IL-1F5 Protein

COA

级别和纯度:

无载体

≥95%(SDS-PAGE)

表达系统: E. coli
Accession #: Q9QYY1
蛋白标签: No tag
生物活性: Testing in progress
内毒素水平: <1.0 EU/μg

有货

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货号 (SKU)	包装规格	是否现货
rp186533-10μg	10μg	现货
rp186533-50μg	50μg	现货
rp186533-100μg	100μg	现货
rp186533-1mg	1mg	期货

查看相关系列

点击查看蛋白信息: IL36RN

Accession#: Q9QYY1 (1) Gene ID: 54450 (1) IL-36Ra/IL-1F5 (2) IL36RN (2)

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基本描述

产品名称	Recombinant Mouse IL-36Ra/IL-1F5 Protein
别名	重组小鼠IL-36Ra/IL-1F5蛋白 \| 重组人白介素36受体α蛋白
英文别名	FIL1 delta \| FIL1 \| FIL1-delta, IL-1RP3, IL-1L1, IL-1-delta) \| FIL1DIL-1 delta \| IL1F5 (Canonical product IL-1F5a) \| IL1F5 \| IL-1HY1 \| IL-1L1 \| IL-1RP3 \| IL36Ra \| IL-36Ra \| IL36RN \| interleukin 1 family, member 5 (delta) \| interleukin 1, delta \| Interleuk
规格或纯度	无载体, ≥95%(SDS-PAGE)
生化机理	Interleukin-1 family member 5 (IL-1F5), also known as interleukin 36 receptor antagonist (IL36RA), is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). IL-1F5 is a highly and specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). IL-1F5 could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist, and interleukin-1 receptor type I (IL-1R1), which is present in epithelial barriers and takes part in the local inflammatory response. It has been proved that IL-1F5 induces IL-4 mRNA and protein expression in glia in vitro and enhances hippocampal expression of IL-4 following intracerebroventricular injection. The inhibitory effect of IL-1F5 on LPS-induced IL-1β is attenuated in cells from IL-4-defective mice. Experiment results suggest that IL-1F5 mediates anti-inflammatory effects through its ability to induce IL-4 production and that this is a consequence of its interaction with the orphan receptor, single Ig IL-1R-related molecule (SIGIRR)/TIR8, as the effects were not observed in SIGIRR-/- mice. In contrast to its effects in brain tissue, IL-1F5 did not attenuate LPS-induced changes, or up-regulated IL-4 in macrophages or dendritic cells, suggesting that the effect is confined to the brain. Post-translational: Removal of N-terminal methionine is necessary for full antagonistic activity.
生物活性	Testing in progress
内毒素水平	<1.0 EU/μg
表达系统	E. coli
种属	小鼠(Mouse)
氨基酸	3-156 aa
序列	VLSGALCFRMKDSALKVLYLHNNQLLAGGLHAEKVIKGEEISVVPNRALDASLSPVILGVQGGSQCLSCGTEKGPILKLEPVNIMELYLGAKESKSFTFYRRDMGLTSSFESAAYPGWFLCTSPEADQPVRLTQIPEDPAWDAPITDFYFQQCD
蛋白标签	No tag
无载体	Yes
无动物源	No
Accession #	Q9QYY1
来源	重组表达
预测分子量	16.9 kDa
SDS-PAGE	15.5 kDa, under reducing conditions; 15.7 kDa, under non-reducing conditions.

储存与运输

物理形态	冻干(Lyophilized)
储存缓冲液	Lyophilized from PBS, pH 7.4
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Store at -20°C for 1 year. Avoid freeze/thaw cycle.
分子类型	蛋白质

图片

SDS-PAGE: Recombinant Mouse IL-36Ra/IL-1F5 Protein (rp186533)

Recombinant Mouse IL-36Ra/IL-1F5 Protein (rp186533) - SDS-PAGE
3 μg/lane of Recombinant Mouse IL-36Ra/IL-1F5 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 15.5 kDa under reducing conditions and 15.7 kDa under non-reducing conditions.

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找到3个结果

批号(Lot Number)	证书类型	货号
ZJ24F1215401	分析证书	rp186533
ZJ24F1215399	分析证书	rp186533
ZJ24F1215400	分析证书	rp186533

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