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Recombinant Rhesus Macaque IL-18/IL-1F4 Protein

Recombinant Rhesus Macaque IL-18/IL-1F4 Protein

COA

级别和纯度:

无载体

≥95%(SDS-PAGE)

表达系统: E. coli
Accession #: Q9BGI5
蛋白标签: No tag
生物活性: Testing in progress
内毒素水平: <1.0 EU/μg

有货

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货号 (SKU)	包装规格	是否现货
rp186516-10μg	10μg	现货
rp186516-50μg	50μg	现货
rp186516-100μg	100μg	现货
rp186516-1mg	1mg	期货

查看相关系列

点击查看蛋白信息: IL18

Accession#: Q9BGI5 (1) Gene ID: 574151 (1) IL-18/IL-1F4 (1) IL18 (10)

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基本描述

产品名称	Recombinant Rhesus Macaque IL-18/IL-1F4 Protein
别名	重组猕猴IL-18/IL-1F4蛋白 \| 重组猕猴白细胞介素18蛋白 \| 重组猕猴白细胞介素-1家族成员4蛋白
英文别名	Iboctadekin \| IFN-gamma-inducing factor \| IGIF \| IGIFIL-1 gamma \| IL18 \| IL-18 \| IL-18MGC12320 \| IL-1F4 \| IL1F4iboctadekin \| IL-1g \| Interferon gamma-inducing factor \| interleukin 18 (interferon-gamma-inducing factor) \| Interleukin-1 gamma \| interleukin-1
规格或纯度	无载体, ≥95%(SDS-PAGE)
生化机理	Interleukin-18 (IL-18), also known as IL-1F4 and IFN-gamma inducing factor (IGIF), is a member of the IL-1 family of cytokines and is a key molecule in the innate immune response. Rhesus IL-18 is synthesized as a 24 kDa proprotein that contains a 36 amino acid (aa) propeptide and a 157 aa mature region. Under inflammatory conditions, the propeptide is cleaved by Caspase-1 in the cytoplasm to liberate the mature nonglycosylated 18 kDa monomeric IL-18. Mature rhesus IL-18 shares 96% aa sequence identity with human IL-18 and 60% - 76% with mouse, rat, canine, feline, and porcine IL-18. IL-18 is secreted by a variety of cell types including macrophages, dendritic cells, and epithelial cells. Circulating mature IL-18 is sequestered by soluble IL-18 binding proteins (IL-18 BP) that inhibit IL-18 bioactivity. IL-18 interacts with the widely expressed IL-18 R alpha which then recruits the signaling subunit IL-18 R beta. The IL-1 family member IL-1F7 also binds to IL-18 R alpha but does not recruit IL-18 R beta or induce signaling. IL-1F7 binds IL-18 BP and enhances its neutralizing effect on IL-18 activity. IL-18 synergizes with other cytokines to activate NK, Th1, and Th17 cells and to increase the production of IFN-gamma. IL-18 can also promote Th2 cytokine release which reduces the effectiveness of antiviral responses. Increased levels of active IL-18 contribute to the severity of autoimmunity and hypertension, while deficiency of IL-18 results in symptoms of metabolic syndrome. In cancer, IL-18 stimulates Th1 and NK cells to target tumor cells, but it can also promote angiogenesis, metastasis, and tumor cell immune evasion.
生物活性	Testing in progress
内毒素水平	<1.0 EU/μg
表达系统	E. coli
种属	恒河猴(Rhesus monkey)
氨基酸	37-193 aa
序列	YFGKLESKLSIIRNLNDQVLFIDQGNRPLFEDMTDSDCRDNAPRTIFIINMYKDSQPRGMAVAISVKCEKISTLSCENRIISFKEMNPPDNIKDTKSDIIFFQRSVPGHDNKMQFESSSYEGYFLACEKERDLYKLILKKKDELGDRSIMFTVQNED
蛋白标签	No tag
无载体	Yes
无动物源	No
Accession #	Q9BGI5
来源	重组表达
预测分子量	18.3 kDa
SDS-PAGE	15.0 kDa, under reducing conditions; 15.3 kDa, under non-reducing conditions.

储存与运输

物理形态	冻干(Lyophilized)
储存缓冲液	Lyophilized from 20mM Tris, 500mM NaCl, 2mM DTT, 1mM EDTA, pH 8.0
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 0.5 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Store at -20°C for 1 year. Avoid freeze/thaw cycle.
分子类型	蛋白质

图片

SDS-PAGE: Recombinant Rhesus Macaque IL-18/IL-1F4 Protein (rp186516)

Recombinant Rhesus Macaque IL-18/IL-1F4 Protein (rp186516) - SDS-PAGE
3 μg/lane of Recombinant Rhesus Macaque IL-18/IL-1F4 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 15.0 kDa under reducing conditions and 15.3 kDa under non-reducing conditions.

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找到3个结果

批号(Lot Number)	证书类型	货号
ZJ25F0217517	分析证书	rp186516
ZJ25F0217516	分析证书	rp186516
ZJ25F0217515	分析证书	rp186516

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