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Recombinant Human CD40/TNFRSF5 Protein

COA COA
  • 表达系统: HEK293
  • Accession #: P25942
  • 蛋白标签: C-His
  • 生物活性: Immobilized Recombinant Human CD40 Protein (rp183577) at 1.0 μg/mL can bind Recombinant Human CD40 Ligand Protein (rp169583) with the EC50 of 20.84 ng/mL.     Immobilized Recombinant Human CD40 Protein (rp183577) at 1.0 μg/mL can bind CD40 Mouse mAb (Ab094764) with the EC50 of 15.35 ng/mL. Immobilized Recombinant Human CD40 Protein (rp183577) at 1.0 μg/mL can bind Ravagalimab (anti-CD40) (Ab182860) with the EC50 of 11.32 ng/mL. Immobilized Recombinant Human CD40 Protein (rp183577) at 1.0 μg/mL can bind Mitazalimab (anti-CD40) (Ab182809) with the EC50 of 4.37 ng/mL. Immobilized Recombinant Human CD40 Protein (rp183577) at 1.0 μg/mL can bind Giloralimab (anti-CD40) (Ab182875) with the EC50 of 25.5 ng/mL.
  • 内毒素水平: <1.0 EU/μg
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货号 (SKU) 包装规格 是否现货 价格 数量
rp183577-10μg
 10μg 现货 Stock Image
rp183577-50μg
 50μg 现货 Stock Image
rp183577-100μg
 100μg 现货 Stock Image
rp183577-1mg
 1mg 期货 Stock Image
大包装询价 收藏夹 比较  SDS下载  DATASHEET  质量标准
查看相关系列
点击查看蛋白信息: CD40
Accession#:P25942 (34) CD40 (40) CD40/TNFRSF5 (1) Gene ID:958 (33)
main product photo

基本描述

产品名称 Recombinant Human CD40/TNFRSF5 Protein
别名 重组人CD40/TNFRSF5 蛋白 | 重组人CD40/TNFRSF5 蛋白 | 重组人 CD40/TNFRSF5 蛋白
英文别名 B cell surface antigen CD40 | B-cell surface antigen CD40 | Bp50B cell-associated molecule | CD40 antigen | CD40 molecule, TNF receptor superfamily member 5 | CD40 type II isoform | CD40 | CD40L receptor | CDw40 | MGC9013 | nerve growth factor receptor-re
规格或纯度 无动物源, Carrier Free, ActiBioPure™, 生物活性, ≥95%(SDS-PAGE)
产品介绍


Protein Function:
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. 
生物活性 Immobilized Recombinant Human CD40 Protein (rp183577) at 1.0 μg/mL can bind Recombinant Human CD40 Ligand Protein (rp169583) with the EC50 of 20.84 ng/mL.     Immobilized Recombinant Human CD40 Protein (rp183577) at 1.0 μg/mL can bind CD40 Mouse mAb (Ab094764) with the EC50 of 15.35 ng/mL. Immobilized Recombinant Human CD40 Protein (rp183577) at 1.0 μg/mL can bind Ravagalimab (anti-CD40) (Ab182860) with the EC50 of 11.32 ng/mL. Immobilized Recombinant Human CD40 Protein (rp183577) at 1.0 μg/mL can bind Mitazalimab (anti-CD40) (Ab182809) with the EC50 of 4.37 ng/mL. Immobilized Recombinant Human CD40 Protein (rp183577) at 1.0 μg/mL can bind Giloralimab (anti-CD40) (Ab182875) with the EC50 of 25.5 ng/mL.
内毒素水平 <1.0 EU/μg
表达系统 HEK293
种属 人(Human)
氨基酸 1-193 aa
序列 MVRLPLQCVLWGCLLTAVHPEPPTACREKQYLINSQCCSLCQPGQKLVSDCTEFTETECLPCGESEFLDTWNRETHCHQHKYCDPNLGLRVQQKGTSETDTICTCEEGWHCTSEACESCVLHRSCSPGFGVKQIATGVSDTICEPCPVGFFSNVSSAFEKCHPWTSCETKDLVVQQAGTNKTDVVCGPQDRLRHHHHHH
蛋白标签 C-His
无载体 Yes
无动物源 Yes
Accession # P25942
来源 重组表达
预测分子量 20.0 kDa
SDS-PAGE 28.7 kDa, under reducing conditions; 27.9 kDa, under non-reducing conditions

储存与运输

物理形态 冻干(Lyophilized)
储存缓冲液 Lyophilized from PBS, pH 7.4
复溶 We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 0.5 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存温度 -20°C储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -20°C 下可保存 1 年。避免冷冻/解冻循环。
分子类型 蛋白质

图片

Recombinant Human CD40/TNFRSF5 Protein (rp183577) - Binding Activity
Immobilized Recombinant Human CD40/TNFRSF5 Protein (rp183577) at 1.0 μg/mL can bind Recombinant Human CD40 Ligand Protein (rp169583) with the EC₅₀ of 20.84 ng/mL.

Recombinant Human CD40/TNFRSF5 Protein (rp183577) - ELISA
Immobilized Recombinant Human CD40/TNFRSF5 Protein (rp183577) at 1.0 μg/mL can bind CD40 Mouse mAb (Ab094764) with the EC₅₀ of 15.35 ng/mL.

Recombinant Human CD40/TNFRSF5 Protein (rp183577) - ELISA
Immobilized Recombinant Human CD40/TNFRSF5 Protein (rp183577) at 1.0 μg/mL can bind Ravagalimab (anti-CD40) (Ab182860) with the EC₅₀ of 11.32 ng/mL.

Recombinant Human CD40/TNFRSF5 Protein (rp183577) - ELISA
Immobilized Recombinant Human CD40/TNFRSF5 Protein (rp183577) at 1.0 μg/mL can bind Mitazalimab (anti-CD40) (Ab182809) with the EC₅₀ of 4.37 ng/mL.

Recombinant Human CD40/TNFRSF5 Protein (rp183577) - ELISA
Immobilized Recombinant Human CD40/TNFRSF5 Protein (rp183577) at 1.0 μg/mL can bind Giloralimab (anti-CD40) (Ab182875) with the EC₅₀ of 25.5 ng/mL.

Recombinant Human CD40/TNFRSF5 Protein (rp183577) - SDS-PAGE
3 μg/lane of Recombinant Human CD40/TNFRSF5 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 28.7 kDa under reducing conditions and 27.9 kDa under non-reducing conditions.

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找到3个结果

批号(Lot Number) 证书类型 货号
ZJ24F1011702 分析证书 rp183577
ZJ24F1011703 分析证书 rp183577
ZJ24F1011704 分析证书 rp183577

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