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Recombinant Human EphA2 Protein

Recombinant Human EphA2 Protein

级别和纯度:

≥95%(SDS-PAGE)

表达系统: HEK293
Accession #: P29317
蛋白标签: C-His
生物活性: Immobilized Recombinant Human EphA2 Protein (rp181601) at 2.0 μg/mL can bind Recombinant Human Ephrin-A4 Protein (rp145636) with the EC50 of 7.414 ng/mL.
内毒素水平: <1.0 EU/μg

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货号 (SKU)	包装规格	是否现货
rp181601-10μg	10μg	现货
rp181601-50μg	50μg	现货
rp181601-100μg	100μg	现货
rp181601-1mg	1mg	期货

查看相关系列

点击查看蛋白信息: EPHA2

Accession#:P29317 (4) EphA2 (4) Gene ID:1969 (4)

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基本描述

产品名称	Recombinant Human EphA2 Protein
别名	重组人EphA2蛋白 \| 重组人EphA2蛋白
英文别名	ARCC2 \| EC 2.7.10 \| EC 2.7.10.1 \| Eck \| ECKepithelial cell receptor protein tyrosine kinase \| EPH receptor A2 \| EphA2 \| ephrin type-A receptor 2 \| Epithelial cell kinase \| Myk2 \| Sek2 \| soluble EPHA2 variant 1 \| Tyrosine-protein kinase receptor ECK
规格或纯度	ActiBioPure™, 生物活性, 无动物源, Carrier Free, ≥95%(SDS-PAGE)
产品介绍	Protein Function: Eph receptor A2 (Ephrin type-A receptor 2 or EphA2) is a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. The Eph receptors' corresponding family of ligands are the ephrins anchored to cell surfaces. The ephrins and Eph receptors are implicated as positional labels that may guide the development of neural topographic maps. They have also been found implicated in embryonic patterning, neuronal targeting, vascular development and adult neovascularization. The large family of ligands and receptors may make a major contribution to the accurate spatial patterning of connections and cell position in the nervous system. Furthermore, elevated expression of Eph receptors and ephrin ligands is associated with tumors and associated tumor vasculature, suggesting the Eph receptors and ephrin ligands also play critical roles in tumor angiogenesis and tumor growth. Unlike most Eph kinases, which are primarily expressed during development, EphA2 is primarily found in adult human epithelial cells. The cellular functions of EphA2 may be regulating cell growth, survival, migration, and angiogenesis.Unlike other receptor tyrosine kinases, ligand binding is not necessary for EphA2. Rather, the ligand appears to regulate EphA2 subcellular localization and its interactions with downstream adapter and signaling proteins. Eph receptor A2(EphA2) has been demonstrated to critically regulate tumor cell growth, migration and invasiveness. Eph receptor A2(EphA2) is frequently overexpressed and functionally altered in aggressive tumor cells, and that these changes promote metastatic character.
生物活性	Immobilized Recombinant Human EphA2 Protein (rp181601) at 2.0 μg/mL can bind Recombinant Human Ephrin-A4 Protein (rp145636) with the EC50 of 7.414 ng/mL.
内毒素水平	<1.0 EU/μg
表达系统	HEK293
种属	人(Human)
氨基酸	1-534 aa
序列	MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYLAFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPIGQCLCQAGYEKVEDACQACSPGFFKFEASESPCLECPEHTLPSPEGATSCECEEGFFRAPQDPASMPCTRPPSAPHYLTAVGMGAKVELRWTPPQDSGGREDIVYSVTCEQCWPESGECGPCEASVRYSEPPHGLTRTSVTVSDLEPHMNYTFTVEARNGVSGLVTSRSFRTASVSINQTEPPKVRLEGRSTTSLSVSWSIPPPQQSRVWKYEVTYRKKGDSNSYNVRRTEGFSVTLDDLAPDTTYLVQVQALTQEGQGAGSKVHEFQTLSPEGSGNHHHHHH
蛋白标签	C-His
无载体	Yes
无动物源	Yes
Accession #	P29317
来源	重组表达
预测分子量	57.0 kDa
SDS-PAGE	60.4 kDa, under reducing conditions; 50.5 kDa, under non-reducing conditions

储存与运输

物理形态	冻干(Lyophilized)
储存缓冲液	Lyophilized from PBS, 5% Trehalose, 5% Mannitol, pH 7.4
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 0.1 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -20°C 下可保存 1 年。避免冷冻/解冻循环。
分子类型	蛋白质

图片

Binding Activity: Recombinant Human EphA2 Protein (rp181601)

Recombinant Human EphA2 Protein (rp181601) - Binding Activity
Immobilized Recombinant Human EphA2 Protein (rp181601) at 2.0 μg/mL can bind Recombinant Human Ephrin-A4 Protein (rp145636) with the EC ₅₀ of 7.414 ng/mL.

SDS-PAGE: Recombinant Human EphA2 Protein (rp181601)

Recombinant Human EphA2 Protein (rp181601) - SDS-PAGE
3 μg/lane of Recombinant Human EphA2 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 60.4 kDa under reducing conditions and 50.5 kDa under non-reducing conditions.

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找到6个结果

批号(Lot Number)	证书类型	货号
ZJ25F0825313	分析证书	rp181601
ZJ25F0825312	分析证书	rp181601
ZJ25F0825311	分析证书	rp181601
ZJ24F1011583	分析证书	rp181601
ZJ24F1011582	分析证书	rp181601
ZJ24F1011581	分析证书	rp181601

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