Recombinant Canis lupus CD19 Protein

COA

级别和纯度:

无动物源

无载体

≥90%(SDS-PAGE)
见COA

表达系统: CHO
Accession #: A0A8C0PU30
蛋白标签: C-hFc & His
内毒素水平: <1.0 EU/μg

有货

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货号 (SKU)	包装规格	是否现货
rp176268-10μg	10μg	现货
rp176268-50μg	50μg	现货
rp176268-100μg	100μg	现货
rp176268-1mg	1mg	期货

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点击查看蛋白信息: CD19

Accession#: A0A8C0PU30 (4) CD19 (76) Gene ID: 607898 (4)

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基本描述

产品名称	Recombinant Canis lupus CD19 Protein
别名	重组狗CD19蛋白 \| 重组狗CD19分子蛋白
英文别名	B4 \| B-lymphocyte antigen CD19 \| B-lymphocyte surface antigen B4 \| CD19 antigen \| CD19 molecule \| CD19 \| CVID3 \| Differentiation antigen CD19 \| Leu-12 \| MGC12802 \| T-cell surface antigen Leu-12
规格或纯度	无动物源, 无载体, ≥90%(SDS-PAGE), 见COA
生化机理	CD19 protein is a ransmembrane glycoprotein that plays a central role in B cell activation and humoral immune responses. CD19 is expressed throughout B cell development from pre-B cells through mature B cells, and it is commonly used as a B cell lineage marker. It is required for the responsiveness of mature B cell to antigen stimulation, germinal center development, and antibody affinity maturation. The CD19 protein associates with the B cell antigen receptor (BCR), CD81, CD38, CD21, CD22, and IFITM1/CD225/Leu13. These associations enable CD19 to amplify B cell signaling and reduce the threshold for antigen stimulation through the BCR. CD19 polymorphisms and up-regulation can lead to the development of autoimmunity by promoting autoantibody production. CD19 has emerged as promising therapeutic target for hematologic cancers and solid tumors. Immunotherapy using a chimeric antigen receptor (CAR) targeting CD19 has proven effective in many different cancers. The first CD19 CAR T cell therapies have been granted FDA approval for the treatment of B cell malignancies with several more in clinical trials. Mature human CD19 protein consists of a 272 amino acid (aa) extracellular domain (ECD) with two Ig-like domains, a 22 aa transmembrane segment, and a 243 aa cytoplasmic domain. Within the ECD, human CD19 shares 57% amino acid sequence identity with mouse and rat CD19.
内毒素水平	<1.0 EU/μg
表达系统	CHO
种属	狗(Canine)
氨基酸	74-350 aa
序列	MPPPRLLFFLLFLTPMEVRPQETLQVEAKEGGKAELPCLKVPSDGPLEQQAWFQGAQSELGLWSQGLGVRKGSLGIQLFVFNVSDQMGGFYLCQPGPPSEQAWQSGWTVSVEGSGELFRWNASALNDSGCGLGNRPSEGPKPSSRYPTSSQLYVWEKDHPEIWETDPECALPRGTLNQSLNQDLIVAPGSTFWLPCEVPPAFVARGPISWTHVRPKKHNISLLSLDLREDAPGREMWVLGTLSGGAVLLLPQATVRDAGTYRCYHGNRTVEMQLKVIAQSVRYWLLETGGWKVPAVPENLYFQGPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH
蛋白标签	C-hFc & His
无载体	Yes
无动物源	Yes
Accession #	A0A8C0PU30
来源	重组表达
预测分子量	58.0 kDa
SDS-PAGE	68.4-95.7 kDa, under reducing conditions

储存与运输

物理形态	冻干(Lyophilized)
储存缓冲液	Lyophilized from PBS, pH 7.4
浓度	见COA
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	-20℃保存 12个月；复溶后建议分装，避免反复冻融。
分子类型	蛋白质

图片

SDS-PAGE: Recombinant Canis lupus CD19 Protein (rp176268)

combinant Canis lupus CD19 Protein (rp176268) - SDS-PAGE
3 μg/lane of Recombinant Canis lupus CD19 Protein was resolved with SDS-PAGE under reducing (R) and visualized by Coomassie® Blue staining, showing a band at 68.4-95.7 kDa.

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批号(Lot Number)	证书类型	货号
ZJ25F0927634	分析证书	rp176268
ZJ25F0927633	分析证书	rp176268
ZJ25F0927632	分析证书	rp176268

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