Recombinant Human CD44 Protein

COA

级别和纯度:

≥95%(SDS-PAGE)

表达系统: HEK293
Accession #: P16070
蛋白标签: C-His
生物活性: Immobilized Recombinant Human CD44 Protein (rp169584) at 1.0 μg/mL can bind Bivatuzumab (anti-CD44v6) (Ab176619) with the EC50 of 15.8 ng/mL.
内毒素水平: <1.0 EU/μg

有货

库存信息

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库存信息

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货号 (SKU)	包装规格	是否现货
rp169584-10μg	10μg	现货
rp169584-50μg	50μg	期货
rp169584-100μg	100μg	期货
rp169584-1mg	1mg	期货

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点击查看蛋白信息: CD44

Accession#:P16070 (6) CD44 (15) Gene ID:960 (7)

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基本描述

产品名称	Recombinant Human CD44 Protein
别名	重组人CD44蛋白 \| 重组人吞噬细胞糖蛋白-1
英文别名	LHR \| BA-1 \| CD 44 \| CD44 \| CD44 antigen \| CD44 molecule \| CD44 molecule (Indian blood group) \| CD44_HUMAN \| CDw44 \| CDW44 antigen \| Cell surface glycoprotein CD44 \| chondroitin sulfate proteoglycan 8 \| CSPG8 \| ECMR-III \| Epican \| Extracellular matrix rec
规格或纯度	ActiBioPure™, 无动物源, 无载体, 生物活性, ≥95%(SDS-PAGE)
生化机理	Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640). Post-translational: Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors.N-glycosylated.O-glycosylated; contains chondroitin sulfate glycans which can be more or less sulfated and whose number may affect the accessibility of specific proteinases to their cleavage site(s). It is uncertain if O-glycosylation occurs on Thr-637 or Thr-638.Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672.
生物活性	Immobilized Recombinant Human CD44 Protein (rp169584) at 1.0 μg/mL can bind Bivatuzumab (anti-CD44v6) (Ab176619) with the EC50 of 15.8 ng/mL.
内毒素水平	<1.0 EU/μg
表达系统	HEK293
种属	人(Human)
氨基酸	1-649 aa
序列	MDKFWWHAAWGLCLVPLSLAQIDLNITCRFAGVFHVEKNGRYSISRTEAADLCKAFNSTLPTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPNSICAANNTGVYILTSNTSQYDTYCFNASAPPEEDCTSVTDLPNAFDGPITITIVNRDGTRYVQKGEYRTNPEDIYPSNPTDDDVSSGSSSERSSTSGGYIFYTFSTVHPIPDEDSPWITDSTDRIPATTLMSTSATATETATKRQETWDWFSWLFLPSESKNHLHTTTQMAGTSSNTISAGWEPNEENEDERDRHLSFSGSGIDDDEDFISSTISTTPRAFDHTKQNQDWTQWNPSHSNPEVLLQTTTRMTDVDRNGTTAYEGNWNPEAHPPLIHHEHHEEEETPHSTSTIQATPSSTTEETATQKEQWFGNRWHEGYRQTPKEDSHSTTGTAAASAHTSHPMQGRTTPSPEDSSWTDFFNPISHPMGRGHQAGRRMDMDSSHSITLQPTANPNTGLVEDLDRTGPLSMTTQQSNSQSFSTSHEGLEEDKDHPTTSTLTSSNRNDVTGGRRDPNHSEGSTTLLEGYTSHYPHTKESRTFIPVTSAKTGSFGVTAVTVGDSNSNVNRSLSGDQDTFHPSGGSHTTHGSESDGHSHGSQEGGANTTSGPIRTPQIPEHHHHHH
蛋白标签	C-His
无载体	Yes
无动物源	Yes
Accession #	P16070
来源	重组表达
预测分子量	69.9 kDa
SDS-PAGE	61.8-120.2 kDa, under reducing conditions; 58.7-110.1 kDa, under non-reducing conditions.

储存与运输

物理形态	冻干(Lyophilized)
储存缓冲液	Lyophilized from PBS, pH 7.4.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Store at -20°C for 1 year. Avoid freeze/thaw cycle.
分子类型	蛋白质

图片

ELISA: Recombinant Human CD44 Protein (rp169584)

Recombinant Human CD44 Protein (rp169584) - ELISA
Immobilized Recombinant Human CD44 Protein (rp169584) at 1.0 μg/mL can bind Bivatuzumab (anti-CD44v6) (Ab176619) with the EC ₅₀ of 15.8 ng/mL

SDS-PAGE: Recombinant Human CD44 Protein (rp169584)

Recombinant Human CD44 Protein (rp169584) - SDS-PAGE
3 μg/lane of Recombinant Human CD44 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 61.8-120.2 kDa under reducing conditions and 58.7-110.1 kDa under non-reducing conditions.

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找到2个结果

批号(Lot Number)	证书类型	货号
ZJ24F1113708	分析证书	rp169584
ZJ24F1113706	分析证书	rp169584

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