Recombinant Mouse Activin RIIB Protein

COA

级别和纯度:

≥95%(SDS-PAGE)

表达系统: HEK293
Accession #: P27040
蛋白标签: C-hFc & His
生物活性: Measured by its ability to inhibit Activin A-induced hemoglobin expression in K562 human chronic myelogenous leukemia cells. The ED50 for this effect is 5-30 ng/mL in the presence of 3 ng/mL of recombinant human Activin A.
内毒素水平: <0.1 EU/μg

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货号 (SKU)	包装规格	是否现货
rp167215-10μg	10μg	现货
rp167215-50μg	50μg	现货
rp167215-100μg	100μg	现货
rp167215-1mg	1mg	期货

查看相关系列

点击查看蛋白信息: ACVR2B

Accession#: P27040 (1) Activin RIIB (5) Acvr2b (7) Gene ID: 11481 (1)

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基本描述

产品名称	Recombinant Mouse Activin RIIB Protein
别名	激活素A受体ⅡB(ACVR2B)重组蛋白
英文别名	activin A receptor, type IIB \| Activin receptor type IIB \| activin receptor type-2B \| Activin RIIB \| ActivinRIIB \| ACTRIIB \| ActR-IIB \| ACVR2B \| EC 2.7.11 \| EC 2.7.11.30 \| MGC116908 \| AI047905 \| 4930516B21Rik
规格或纯度	ActiBioPure™, 生物活性, 无动物源, Carrier Free, High performance, ≥95%(SDS-PAGE)
产品介绍	Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor (By similarity).
生物活性	Measured by its ability to inhibit Activin A-induced hemoglobin expression in K562 human chronic myelogenous leukemia cells. The ED50 for this effect is 5-30 ng/mL in the presence of 3 ng/mL of recombinant human Activin A.
内毒素水平	<0.1 EU/μg
表达系统	HEK293
种属	小鼠(Mouse)
氨基酸	19-134 aa
序列	SGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEPGGPEVTYEPPPTAPTENLYFQGMDPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH
蛋白标签	C-hFc & His
无载体	Yes
无动物源	Yes
Accession #	P27040
来源	重组表达
预测分子量	41 kDa
SDS-PAGE	53 - 67 kDa, under reducing conditions; 100 - 145 & 250 kDa, under non-reducing conditions.

储存与运输

物理形态	冻干(Lyophilized)
储存缓冲液	Lyophilized from 10mM PBS, 5% Trehalose, 5% Mannitol, pH 7.4
复溶	Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -20~-80℃ 下可保存 1 年以上。收货后建议分装。避免冷冻/解冻循环。
分子类型	蛋白质

图片

SDS-PAGE: Recombinant Mouse Activin RIIB Protein (rp167215)

Recombinant Mouse Activin RIIB Protein (rp167215) - SDS-PAGE
3 μg/lane of Recombinant Mouse Activin RIIB Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 53 - 67 kDa under reducing condition and 100 - 145 kDa & 250 under non-reducing condition.

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批号(Lot Number)	证书类型	货号
ZJ25F0217774	分析证书	rp167215
ZJ25F0217773	分析证书	rp167215
ZJ25F0217772	分析证书	rp167215

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