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Recombinant Human IL-17RC Isoform 1 Protein

Recombinant Human IL-17RC Isoform 1 Protein

级别和纯度:

≥95%(SDS-PAGE)

表达系统: HEK293
Accession #: Q8NAC3-2
蛋白标签: C-hFc & His
生物活性: Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human IL-17A Protein at 2 μg/mL can bind Recombinant Human IL-17RC Isoform 1 Protein (rp166864), the ED50 for this effect is 21.48 ng/mL.
内毒素水平: <0.1 EU/μg

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货号 (SKU)	包装规格	是否现货
rp166864-10μg	10μg	现货
rp166864-50μg	50μg	现货
rp166864-100μg	100μg	现货
rp166864-1mg	1mg	期货

查看相关系列

点击查看蛋白信息: IL17RC

Accession#: Q8NAC3 (1) Gene ID: 84818 (1) IL17RC (1)

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基本描述

产品名称	Recombinant Human IL-17RC Isoform 1 Protein
别名	重组人IL-17RC Isoform 1蛋白 \| 重组人白介素17受体C蛋白
英文别名	Interleukin 17 Receptor C, Transcript Variant 3 \| FLJ95963 \| FLJ96005 \| IL-17 RC \| IL-17 receptor C \| IL-17 RL \| IL17F receptor \| IL17RC \| IL-17RC \| IL17Rhom \| IL17RL \| IL-17RL \| IL17-RL \| interleukin 17 receptor C \| interleukin-17 receptor C \| Interleuki
规格或纯度	ActiBioPure™, Carrier Free, 生物活性, 无动物源, ≥95%(SDS-PAGE)
产品介绍	Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (By similarity). Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA. Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA. Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA. Upon binding of IL17F homodimer triggers downstream activation of TRAF6 and NF-kappa-B signaling pathway. Induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi (By similarity). Promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression (By similarity). Binding of IL17A-IL17F to IL17RA-IL17RC heterodimeric receptor complex triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. Primarily induces neutrophil activation and recruitment at infection and inflammatory sites (By similarity). Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity).
生物活性	Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human IL-17A Protein at 2 μg/mL can bind Recombinant Human IL-17RC Isoform 1 Protein (rp166864), the ED50 for this effect is 21.48 ng/mL.
内毒素水平	<0.1 EU/μg
表达系统	HEK293
种属	人(Human)
氨基酸	21-465 aa
序列	LERLVGPQDATHCSPGLSCRLWDSDILCLPGDIVPAPGPVLAPTHLQTELVLRCQKETDCDLCLRVAVHLAVHGHWEEPEDEEKFGGAADSGVEEPRNASLQAQVVLSFQAYPTARCVLLEVQVPAALVQFGQSVGSVVYDCFEAALGSEVRIWSYTQPRYEKELNHTQQLPDCRGLEVWNSIPSCWALPWLNVSADGDNVHLVLNVSEEQHFGLSLYWNQVQGPPKPRWHKNLTGPQIITLNHTDLVPCLCIQVWPLEPDSVRTNICPFREDPRAHQNLWQAARLQLLTLQSWLLDAPCSLPAEAALCWRAPGGDPCQPLVPPLSWENVTVDKVLEFPLLKGHPNLCVQVNSSEKLQLQECLWADSLGPLKDDVLLLETRGPQDNRSLCALEPSGCTSLPSKASTRAARLGEYLLQDLQSGQCLQLWDDDLGALWACPMDKYIHENLYFQGMDPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH
蛋白标签	C-hFc & His
无载体	Yes
无动物源	Yes
Accession #	Q8NAC3-2
来源	重组表达
预测分子量	77.3 kDa
SDS-PAGE	95-113 kDa under reducing conditions.

储存与运输

物理形态	冻干(Lyophilized)
储存缓冲液	Lyophilized from 10mM PBS, 5% Trehalose, 5% Mannitol, pH7.4.
复溶	Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -20~-80℃ 下可保存 1 年以上。复溶后建议分装。避免冷冻/解冻循环。
分子类型	蛋白质

图片

SDS-PAGE: Recombinant Human IL-17RC Isoform 1 Protein (rp166864)

Recombinant Human IL-17RC Isoform 1 Protein (rp166864) - SDS-PAGE
2 μg/lane of Recombinant Human IL-17RC Isoform 1 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 100 - 129 kDa under reducing condition and 204 - 260 kDa under non-reducing condition.
IL-17RC can form disulfide-linked homodimers, which is of significant importance for the IL-17 signaling mechanism (PubMed:32187518).

Protein Bioactivity: Recombinant Human IL-17RC Isoform 1 Protein (rp166864)

Recombinant Human IL-17RC Isoform 1 Protein (rp166864) - Protein Bioactivity
Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human IL-17A Protein at 2 μg/mL can bind Recombinant Human IL-17RC Isoform 1 Protein (rp166864), the ED₅₀ for this effect is 21.48 ng/mL.

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找到3个结果

批号(Lot Number)	证书类型	货号
ZJ25F0723524	分析证书	rp166864
ZJ25F0723523	分析证书	rp166864
ZJ25F0723525	分析证书	rp166864

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