Recombinant Mouse ErbB3/Her3 Protein

COA

级别和纯度:

≥90%(SDS-PAGE)

表达系统: HEK293
Accession #: Q61526
蛋白标签: C-hFc & His
生物活性: Measured by its binding ability in a functional ELISA. Immobilized Recombinant Mouse ErbB3/Her3 Protein (rp166491) at 2 μg/mL can bind Recombinant Human NRG1-beta1Protein, the ED50 for this effect is 60.44 ng/mL.
内毒素水平: <0.1 EU/μg

有货

库存信息

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货号 (SKU)	包装规格	是否现货
rp166491-10μg	10μg	现货
rp166491-50μg	50μg	现货
rp166491-100μg	100μg	现货
rp166491-1mg	1mg	期货

查看相关系列

点击查看蛋白信息: ERBB3

Accession#: Q61526 (1) ERBB3 (11) Gene ID: 13867 (1) HER3 (11)

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基本描述

产品名称	Recombinant Mouse ErbB3/Her3 Protein
别名	V-Erb B2红白血病病毒癌基因同源物3(ErbB3)重组蛋白 \| 受体酪氨酸蛋白激酶erbB-3
英文别名	EC 2.7.10 \| EC 2.7.10.1 \| ErbB3 \| ErbB-3 \| erbB3-S \| HER3 \| HER3c-erbB-3 \| LCCS2 \| c-erbB3 \| lethal congenital contracture syndrome 2 \| MDA-BF-1 \| MGC88033 \| p180-ErbB3 \| p45-sErbB3 \| p85-sErbB3 \| Proto-oncogene-like protein c-ErbB-3 \| receptor tyrosine-p
规格或纯度	ActiBioPure™, Bioactive, Animal Free, Carrier Free, ≥90%(SDS-PAGE)
产品介绍	The ErbB3 gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain. It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, bladder and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterized.
生物活性	Measured by its binding ability in a functional ELISA. Immobilized Recombinant Mouse ErbB3/Her3 Protein (rp166491) at 2 μg/mL can bind Recombinant Human NRG1-beta1Protein, the ED50 for this effect is 60.44 ng/mL.
内毒素水平	<0.1 EU/μg
表达系统	HEK293
种属	小鼠(Mouse)
氨基酸	20-641 aa
序列	SEMGNSQAVCPGTLNGLSVTGDADNQYQTLYKLYEKCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSVLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRFTQLTEILLGGVYIEKNDKLCHMDTIDWRDIVRVPDAEIVVKNNGGNCPPCHEVCKGRCWGPGPEDCQILTKTICAPQCNGRCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPAPLVYNKLTFQLEPNPHIKYQYGGVCVASCPHNFVVDQTFCVRACPADKMEVDKNGLKMCEPCRGLCPKACEGTGSGSRYQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRVYISANQQLCYHHSLNWTRLLRGPAEERLDIKYNRPLGECVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSREGVCVTHCNVLQGEPREFVHEAHCFSCHPECQPMEGTSTCNGSGSDACARCAHFRDGPHCVNSCPHGILGAKGPIYKYPDAQNECRPCHENCTQGCKGPELQDCLGQAEVLMSKPHENLYFQGMDPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH
蛋白标签	C-hFc & His
无载体	Yes
无动物源	Yes
Accession #	Q61526
来源	重组表达
预测分子量	96.4 kDa
SDS-PAGE	120-135 kDa, under reducing conditions

储存与运输

物理形态	冻干(Lyophilized)
储存缓冲液	Lyophilized from 10mM PBS, 5% Trehalose, 5% Mannitol, pH 7.4
复溶	Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -20~-80℃ 下可保存 1 年以上。复溶后建议分装。避免冷冻/解冻循环。
分子类型	蛋白质

图片

SDS-PAGE: Recombinant Mouse ErbB3/Her3 Protein (rp166491)

Recombinant Mouse ErbB3/Her3 Protein (rp166491) - SDS-PAGE
2 μg/lane of Recombinant Mouse ErbB3/Her3 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 125 kDa under reducing condition and 270 kDa under non-reducing condition.

Protein Bioactivity: Recombinant Mouse ErbB3/Her3 Protein (rp166491)

Recombinant Mouse ErbB3/Her3 Protein (rp166491) - Protein Bioactivity
Measured by its binding ability in a functional ELISA. Immobilized Recombinant Mouse ErbB3/Her3 Protein (rp166491) at 2 μg/mL can bind Recombinant Human NRG1-beta1Protein, the ED₅₀ for this effect is 60.44 ng/mL.

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找到3个结果

批号(Lot Number)	证书类型	货号
ZJ25F0723521	分析证书	rp166491
ZJ25F0723520	分析证书	rp166491
ZJ25F0723522	分析证书	rp166491

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