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Recombinant Human IL-6/IL-6R alpha Protein

  • 表达系统: HEK293
  • Accession #: P08887,P05231
  • 蛋白标签: C-His
  • 生物活性: Measured by its ability to inhibit M1 mouse myeloid leukemia cell proliferation. The ED50 for this effect is 2.5-12.5 ng/mL.
  • 内毒素水平: <0.1 EU/μg
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货号 (SKU) 包装规格 是否现货 价格 数量
rp164646-10μg
10μg 现货 Stock Image
rp164646-50μg
50μg 现货 Stock Image
rp164646-100μg
100μg 现货 Stock Image
rp164646-1mg
1mg 期货 Stock Image

基本描述

产品名称 Recombinant Human IL-6/IL-6R alpha Protein
别名 白介素6受体和白介素6复合物重组蛋白
英文别名 IL-6/IL-6R alpha Complex | IL6 | IL6R | CDF | HGF | HSF | BSF2 | IL-6 | BSF-2 | IFNB2 | IFN-beta-2 | IL6Q | gp80 | CD126 | HIES5 | IL-6R | IL6RA | IL6RQ | IL-1Ra | IL-6RA | IL6QTL | IL-6R-1
规格或纯度 无动物源, Carrier Free, 生物活性, ActiBioPure™, High performance, ≥90%(SDS-PAGE)
产品介绍


Function

Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.
Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.

生物活性 Measured by its ability to inhibit M1 mouse myeloid leukemia cell proliferation. The ED50 for this effect is 2.5-12.5 ng/mL.
内毒素水平 <0.1 EU/μg
表达系统 HEK293
种属 人(Human)
氨基酸 20-358 aa & 30-212 aa
序列 LAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSANATSLPVQDGGGSGGGSGGGSVPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQMHHHHHH
蛋白标签 C-His
无载体 Yes
无动物源 Yes
Accession # P08887,P05231
来源 重组表达
预测分子量 59 kDa
SDS-PAGE 78-93 kDa, under reducing conditions

储存与运输

物理形态 冻干(Lyophilized)
储存缓冲液 Lyophilized from 10mM PBS, 5% Trehalose, 5% Mannitol, pH 7.4
复溶 Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
储存温度 -20°C储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -20~-80℃ 下可保存 1 年以上。复溶后建议分装。避免冷冻/解冻循环。
分子类型 蛋白质

图片

Recombinant Human IL-6/IL-6R alpha Protein (rp164646) - SDS-PAGE
2 μg/lane of Recombinant Human IL-6/IL-6R alpha Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 70 - 90 kDa.

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批号(Lot Number) 证书类型 货号
ZJ25F0622315 分析证书 rp164646
ZJ25F0622314 分析证书 rp164646
ZJ25F0622313 分析证书 rp164646

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