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Recombinant Human AIF-1/Iba1 Protein

Recombinant Human AIF-1/Iba1 Protein

COA

级别和纯度:

无载体

无叠氮钠

≥90%(SDS-PAGE)

表达系统: E. coli
Accession #: P55008
蛋白标签: N-His
内毒素水平: <1.0 EU/μg

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货号 (SKU)	包装规格	是否现货
rp156641-10μg	10μg	现货
rp156641-50μg	50μg	现货
rp156641-100μg	100μg	现货
rp156641-1mg	1mg	期货

查看相关系列

点击查看蛋白信息: AIF1

Accession#:P55008 (3) AIF1 (3) Gene ID:199 (3) Iba1 (3)

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基本描述

产品名称	Recombinant Human AIF-1/Iba1 Protein
别名	重组人AIF-1蛋白 \| 重组人 AIF-1/Iba1 蛋白
英文别名	AIF \| 1AIF-1 \| Aif1 \| AIF1 protein \| AIF1_HUMAN \| Allograft inflammatory factor 1 \| Allograft inflammatory factor 1 splice variant G \| allograft inflammatory factor-1 splice variant Hara-1 \| balloon angioplasty responsive transcription \| BART 1 \| G1 \| G1
规格或纯度	Carrier Free, Azide Free, ≥90%(SDS-PAGE)
产品介绍	Purity: >90%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description: AIF1, also known as IBA1, is an actin-binding protein. AIF1 is expressed selectively in human macrophage-like cell lines, and in a subset of CD68(+) macrophages in the interstitial and perivascular spaces of human heart allografts. It is expressed in macrophages and neutrophils. AIF1 enhances membrane ruffling and RAC activation. AIF1 enhances the actin-bundling activity of LCP1. It also enhances lymphocyte migration. AIF1 may play a role in macrophage activation and function. It binds calcium and plays a role in RAC signaling and in phagocytosis. It promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes.Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.
内毒素水平	<1.0 EU/μg
表达系统	E. coli
种属	人(Human)
氨基酸	1-147 aa
序列	MGHHHHHHMSQTRDLQGGKAFGLLKAQQEERLDEINKQFLDDPKYSSDEDLPSKLEGFKEKYMEFDLNGNGDIDIMSLKRMLEKLGVPKTHLELKKLIGEVSSGSGETFSYPDFLRMMLGKRSAILKMILMYEEKAREKEKPTGPPAKKAISELP
纯度	＞90% (SDS-PAGE)
蛋白标签	N-His
无载体	Yes
Accession #	P55008
来源	重组表达
预测分子量	17.7 kDa
SDS-PAGE	17.7 kDa

储存与运输

物理形态	冻干(Lyophilized)
储存缓冲液	Lyophilized from 10mM PBS, PH7.4
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -20°C 下可保存 1 年，在 2-8°C 下可保存 1 个月。避免冷冻/解冻循环。
分子类型	蛋白质

图片

SDS-PAGE: Recombinant Human AIF-1/Iba1 Protein(rp156641)

Recombinant Human AIF-1/Iba1 Protein (rp156641) - SDS-PAGE
3 μg/lane of Recombinant Human AIF-1/Iba1 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 17.3 kDa.

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找到3个结果

批号(Lot Number)	证书类型	货号
ZJ23F0700569	分析证书	rp156641
ZJ23F0700570	分析证书	rp156641
ZJ23F0700571	分析证书	rp156641

引用文献

1. Holzinger, I I and 5 more authors.. (1995) Cloning and genomic characterization of LST1: a new gene in the human TNF region.. Immunogenetics, [PMID:7590964]
2. Albertella, M R MR and Campbell, R D RD.. (1994) Characterization of a novel gene in the human major histocompatibility complex that encodes a potential new member of the I kappa B family of proteins.. Human molecular genetics, [PMID:8081366]
3. Utans, U U and 6 more authors.. (1996) Allograft inflammatory factory-1. A cytokine-responsive macrophage molecule expressed in transplanted human hearts.. Transplantation, (15): [PMID:8629302]
4. and Autieri, M V MV.. (1996) cDNA cloning of human allograft inflammatory factor-1: tissue distribution, cytokine induction, and mRNA expression in injured rat carotid arteries.. Biochemical and biophysical research communications, (1): [PMID:8912632]
5. de Baey, A A and 5 more authors.. (1997) Complex expression pattern of the TNF region gene LST1 through differential regulation, initiation, and alternative splicing.. Genomics, (1): [PMID:9367684]
6. Neville, M J MJ and Campbell, R D RD.. (1999) A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:10202016]
7. Xie, Tao T and 7 more authors.. (2003) Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.. Genome research, [PMID:14656967]
8. Chen, Xing X, Kelemen, Sheri E SE and Autieri, Michael V MV.. (2004) AIF-1 expression modulates proliferation of human vascular smooth muscle cells by autocrine expression of G-CSF.. Arteriosclerosis, thrombosis, and vascular biology, [PMID:15117732]
9. Kelemen, Sheri E SE and Autieri, Michael V MV.. (2005) Expression of allograft inflammatory factor-1 in T lymphocytes: a role in T-lymphocyte activation and proliferative arteriopathies.. The American journal of pathology, [PMID:16049345]
10. Yamada, Mitsugu M, Ohsawa, Keiko K, Imai, Yoshinori Y, Kohsaka, Shinichi S and Kamitori, Shigehiro S.. (2006) X-ray structures of the microglia/macrophage-specific protein Iba1 from human and mouse demonstrate novel molecular conformation change induced by calcium binding.. Journal of molecular biology, (1): [PMID:17011575]
11. Schulze, Jörg O JO and 11 more authors.. (2008) Structural and functional characterization of human Iba proteins.. The FEBS journal, [PMID:18699778]

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