Recombinant Mouse TGF-beta RII Protein

COA

级别和纯度:

≥95%(SDS-PAGE)

表达系统: HEK293
Accession #: Q62312-1
蛋白标签: C-hFc & His
生物活性: Measured by its ability to inhibit TGF-beta 1 activity on HT2 mouse T cells. The ED50 for this effect is 3-10 ng/mL in the presence of 1 ng/mL of rhTGF-beta 1.
内毒素水平: <0.1 EU/μg

有货

库存信息

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货号 (SKU)	包装规格	是否现货
rp154716-10μg	10μg	现货
rp154716-50μg	50μg	现货
rp154716-100μg	100μg	现货
rp154716-1mg	1mg	期货

查看相关系列

点击查看蛋白信息: TGFBR2

Accession#: Q62312 (1) Gene ID: 21813 (1) TGF beta Receptor II (3) TGF-beta RIII (2) Tgfbr2 (3)

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基本描述

产品名称	Recombinant Mouse TGF-beta RII Protein
别名	重组小鼠TGF-beta RII蛋白 \| 重组小鼠转化生长因子β受体Ⅱ蛋白 \| 重组小鼠TGF-beta RII蛋白 \| 重组小鼠转化生长因子β受体Ⅱ蛋白
英文别名	Transforming Growth Factor beta Receptor II \| AAT3 \| EC 2.7.11 \| EC 2.7.11.30 \| FAA3 \| HNPCC6 \| LDS1B \| LDS2B \| MFS2 \| RIIC \| TAAD2 \| tbetaR-II \| TGF-beta receptor type II \| TGF-beta receptor type IIB \| TGF-beta receptor type-2 \| TGF-beta RII \| TGF-beta t
规格或纯度	无动物源, Carrier Free, 生物活性, ActiBioPure™, High performance, ≥95%(SDS-PAGE)
产品介绍	Function Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.
生物活性	Measured by its ability to inhibit TGF-beta 1 activity on HT2 mouse T cells. The ED50 for this effect is 3-10 ng/mL in the presence of 1 ng/mL of rhTGF-beta 1.
内毒素水平	<0.1 EU/μg
表达系统	HEK293
种属	小鼠(Mouse)
氨基酸	24-184 aa
序列	RVHRQQKLSPSWESSKPRKLMDFSDNCAIILEDDRSDISSTCANNINHNT ELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYSSWKT EKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTR HVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKN DLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENV ESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKD SVLRDRGRPEIPSFWLNHQGIQIVCETLTECWDHDPEARLTAQCVAERFS ELEHPERLSGRSCSQEKIPEDGSLNTTK
蛋白标签	C-hFc & His
无载体	Yes
无动物源	Yes
Accession #	Q62312-1
来源	重组表达
预测分子量	45.9 kDa
SDS-PAGE	55 - 65 kDa, under reducing conditions; 100 - 130 & 240 - 260 kDa, under non-reducing conditions.

储存与运输

物理形态	冻干(Lyophilized)
储存缓冲液	Lyophilized from 10mM PBS, 5% Trehalose, 5% Mannitol, pH7.4.
复溶	Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -20~-80℃ 下可保存 1 年以上。收货后建议分装。避免冷冻/解冻循环。
分子类型	蛋白质

图片

SDS-PAGE: Recombinant Mouse TGF-beta RII Protein (rp154716)

Recombinant Mouse TGF-beta RII Protein (rp154716) - SDS-PAGE
2 μg/lane of Recombinant Mouse TGF-beta RII Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 55 - 65 kDa under reducing conditions and 100 - 130 & 240 - 260 kDa under non-reducing conditions.

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找到3个结果

批号(Lot Number)	证书类型	货号
ZJ25F0420505	分析证书	rp154716
ZJ25F0420504	分析证书	rp154716
ZJ25F0420503	分析证书	rp154716

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