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Recombinant Human PD-L2/B7-DC Protein

  • 表达系统: HEK293
  • Accession #: Q9BQ51
  • 蛋白标签: C-His
  • 生物活性: Immobilized Recombinant Human PD-L2 at 5 μg/mL (100 μL/well) can bind Recombinant Human PD-1 with a linear range of 0.2-1.0 μg/mL.
  • 内毒素水平: <0.01 EU/μg
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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
rp150034-20μg
20μg 现货 Stock Image
rp150034-100μg
100μg 现货 Stock Image
rp150034-1mg
1mg 期货 Stock Image

基本描述

产品名称 Recombinant Human PD-L2/B7-DC Protein
别名 重组人细胞程序性死亡蛋白1配体2
英文别名 B7-DC | bA574F11.2 | Btdc | Butyrophilin B7-DC | Butyrophilin-like Protein | CD273 antigen | CD273 | CD273PD-1 ligand 2 | MGC142240 | PD-1-ligand 2 | PDCD1L2MGC142238 | PDCD1LG2 | PDL2 | PD-L2 | PDL2B7DC | PD-L2PDCD1 ligand 2 | programmed cell death 1 lig
规格或纯度 ActiBioPure™, Bioactive, Animal Free, Carrier Free, Azide Free, ≥95%(SDS-PAGE)
产品介绍


Purity

>95% HPLC, SDS-PAGE


Additional sequence information

N-terminal glycine


Function

Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.

生物活性 Immobilized Recombinant Human PD-L2 at 5 μg/mL (100 μL/well) can bind Recombinant Human PD-1 with a linear range of 0.2-1.0 μg/mL.
内毒素水平 <0.01 EU/μg
表达系统 HEK293
种属 人(Human)
氨基酸 20-219 aa
序列 LFTVTVPKELYIIEHGSNVTLECNFDTGSHVNLGAITASLQKVENDTSPHRERATLLEEQLPLGKASFHIPQVQVRDEGQYQCIIIYGVAWDYKYLTLKVKASYRKINTHILKVPETDEVELTCQATGYPLAEVSWPNVSVPANTSHSRTPEGLYQVTSVLRLKPPPGRNFSCVFWNTHVRELTLASIDLQSQMEPRTHPHHHHHH
纯度 >95%(SDS-PAGE)
蛋白标签 C-His
无动物源 Yes
Accession # Q9BQ51
来源 重组表达
预测分子量 23 kDa

储存与运输

物理形态 冻干(Lyophilized)
储存缓冲液 10mM PBS (PH7.4), containing 5% trehalose, 5% mannitol
复溶 Reconstitute in water to a concentration of 0.1-1.0 mg/ml.
储存温度 -20°C储存
运输条件 超低温冰袋运输
稳定性与储存 在 -20~-80℃ 下可保存 1 年以上。
分子类型 蛋白质

图片

Recombinant Human PD-L2/B7-DC Protein (rp150034) - SDS-PAGE
2 μg/lane of Recombinant Human PD-L2/B7-DC Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 38 - 48 kDa.

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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找到2个结果

批号(Lot Number) 证书类型 货号
ZJ25F0724796 分析证书 rp150034
ZJ25F0724795 分析证书 rp150034

引用文献

1. Latchman, Y Y and 20 more authors..  (2001)  PD-L2 is a second ligand for PD-1 and inhibits T cell activation..  Nature immunology,  [PMID:11224527]
2. Tseng, S Y SY and 9 more authors..  (2001)  B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells..  The Journal of experimental medicine,  (2): [PMID:11283156]
3. Humphray, S J SJ and 147 more authors..  (2004)  DNA sequence and analysis of human chromosome 9..  Nature,  (27): [PMID:15164053]
4. He, Xian-Hui XH, Liu, Yi Y, Xu, Li-Hui LH and Zeng, Yao-Ying YY..  (2004)  Cloning and identification of two novel splice variants of human PD-L2..  Acta biochimica et biophysica Sinica,  [PMID:15253154]
5. Zhang, Zemin Z and Henzel, William J WJ..  (2004)  Signal peptide prediction based on analysis of experimentally verified cleavage sites..  Protein science : a publication of the Protein Society,  [PMID:15340161]

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