Recombinant Human B7-H2 Protein

COA

级别和纯度:

≥95%(SDS-PAGE)

表达系统: HEK293
Accession #: O75144
蛋白标签: C-His
生物活性: Immobilized Human ICOSLG at 1 μg/mL (100 μL/well) can bind Human ICOS/CD278 with a linear range of 2-15 ng/mL.
内毒素水平: <0.01 EU/μg

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货号 (SKU)	包装规格	是否现货
rp147187-20μg	20μg	现货
rp147187-100μg	100μg	现货
rp147187-1mg	1mg	期货
rp147187-200μg	200μg	期货

查看相关系列

点击查看蛋白信息: ICOSLG

Accession#:O75144 (2) B7-H2 (4) Gene ID:23308 (3) ICOSLG (4)

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基本描述

产品名称	Recombinant Human B7-H2 Protein
别名	重组人T-细胞可诱导共刺激分子配体蛋白 \| 重组人 B7-H2 蛋白
英文别名	B7H2 \| B7-H2 \| B7H2B7 homolog 2 \| B7-H2B7-related protein 1 \| B7RP-1 \| B7RP1B7-like protein Gl50 \| LICOS \| CD275 antigen \| CD275 \| GL50 \| GL50transmembrane protein B7-H2 ICOS ligand \| ICOSL \| ICOS-L \| ICOSLG \| inducible T-cell co-stimulator ligand \| KIAA0
规格或纯度	ActiBioPure™, Bioactive, Animal Free, Carrier Free, Azide Free, ≥95%(SDS-PAGE)
产品介绍	Purity >95% SDS-PAGE. Function Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.
生物活性	Immobilized Human ICOSLG at 1 μg/mL (100 μL/well) can bind Human ICOS/CD278 with a linear range of 2-15 ng/mL.
内毒素水平	<0.01 EU/μg
表达系统	HEK293
种属	人(Human)
氨基酸	19-258 aa
序列	DTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESKTVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERDKITENPVSTGEKNAATWSHHHHHH
纯度	＞95%(SDS-PAGE)
蛋白标签	C-His
无载体	Yes
无动物源	Yes
Accession #	O75144
来源	重组表达
预测分子量	26 kDa

储存与运输

物理形态	冻干(Lyophilized)
储存缓冲液	10mM PBS(PH7.4), containing 5% trehalose, 5% mannitol
复溶	Reconstitute in water to a concentration of 0.1-1.0 mg/ml.
储存温度	-20°C储存
运输条件	超低温冰袋运输
稳定性与储存	在 -20~ -80℃ 下可保存 1 年以上。
分子类型	蛋白质

图片

Protein Bioactivity: Recombinant Human B7-H2 Protein (rp147187)

Recombinant Human B7-H2 Protein (rp147187) - Protein Bioactivity
Immobilized Recombinant Human B7-H2 Protein (rp147187) at 1.0 μg/mL can bind Human ICOS/CD278 with a linear range of 2.0 -15.0 ng/mL.

SDS-PAGE: Recombinant Human B7-H2 Protein (rp147187)

Recombinant Human B7-H2 Protein (rp147187) - SDS-PAGE
3 μg/lane of Recombinant Human B7-H2 was resolved with SDS-PAGE under reducing (R) condition and visualized by Coomassie® Blue staining, showing the band at 43.1 - 55.3 kDa.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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找到2个结果

批号(Lot Number)	证书类型	货号
ZJ23F1101638	分析证书	rp147187
ZJ23F1101639	分析证书	rp147187

引用文献

1. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O. (1998) Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.. DNA Res, 5 (3): (169-76). [PMID:9734811]
2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P et al.. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res, 14 (10B): (2121-7). [PMID:15489334]
3. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K et al.. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat Genet, 36 (1): (40-5). [PMID:14702039]
4. Ling, V V and 12 more authors.. (2000) Cutting edge: identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:10657606]
5. Aicher, A A and 8 more authors.. (2000) Characterization of human inducible costimulator ligand expression and function.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:10779774]
6. Hattori, M M and 64 more authors.. (2000) The DNA sequence of human chromosome 21.. Nature, (18): [PMID:10830953]
7. Wang, S S and 6 more authors.. (2000) Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS.. Blood, (15): [PMID:11023515]
8. Liu, Tao T and 6 more authors.. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.. Journal of proteome research, [PMID:16335952]
9. Ramagopal, Udupi A UA and 12 more authors.. (2017) Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab.. Proceedings of the National Academy of Sciences of the United States of America, (23): [PMID:28484017]

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