RORγt inverse agonist 13

COA

级别和纯度:

≥99%

CAS编号: 2170477-75-3
分子式: C₂₃H₁₇Cl₂F₃N₂O₄
分子量: 513.29

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货号 (SKU)	包装规格	是否现货
R650355-5mg	5mg	期货
R650355-10mg	10mg	期货
R650355-25mg	25mg	期货
R650355-50mg	50mg	期货
R650355-100mg	100mg	期货

查看相关系列

Metabolic Enzyme/Protease (4889) ROR (47) Vitamin D Related/Nuclear Receptor (908) 脂质代谢 (4331)

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基本描述

别名	RORγt 反向激动剂 13
规格或纯度	≥99%
英文名称	RORγt inverse agonist 13
生化机理	RORγt 反向激动剂 13（化合物 3i）是一种强效、具有口服活性和选择性的 RORγt 反向激动剂，具有改进的类似药剂特性，其 IC 50 为 63.8 nM。
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist, with improved agent-like properties, with an IC 50 of 63.8 nM In Vitro RORγt inverse agonist 13 (Compound 3i) exhibits activity with an inhibition of 76% at 0.3 µM in Th17 cell differentiation assay. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo RORγt inverse agonist 13 (Compound 3i, 25 mg/kg, Orally, twice daily) demonstrats excellent in vivo PK profile in mice and good in vivo efficacy in an IMQ-induced psoriasis mice model . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Imiquimod (IMQ)-induced psoriasis mice model . Dosage: 25 mg/kg. Administration: Orally, twice daily. Result: Brought in a significant reduction in clinical severity of psoriasis as measured through the ear erythema, back skin erythema and scaliness scales. Animal Model: Male CD-1 Mice . Dosage: 1 mg/kg (i.v.) and 5 mg/kg (p.o.)(Pharmacokinetic Analysis). Administration: IV or PO, single dose. Result: C max : 609.67 ng/mL (PO), 1550 ng/mL (IV). T 1/2 : 3.63 h (PO), 3.04 h (IV). Form:Solid IC50& Target:ROR-γ 63.8 nM (IC 50 )
纯度	≥99%

名称和识别符

Smiles	O=C(O)CC1=CC=C(CNC(NC2=CC(Cl)=C(C3=CC=CC=C3OC(F)(F)F)C(Cl)=C2)=O)C=C1
分子量	513.29

化学和物理性质

溶解性	DMSO : 100 mg/mL (194.82 mM; Need ultrasonic)

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