| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| R647132-1mg |
1mg |
期货  |
| |
| R647132-5mg |
5mg |
期货 |
|
| 规格或纯度 | ≥99% |
|---|---|
| 英文名称 | RB-3 |
| 生化机理 | RB-3 是一种 PRC1 抑制剂，能与 RING1B-BMI1f 结合，其 K d 为 2.8 μM。 |
| 储存温度 | 2-8°C储存,避光,干燥 |
| 运输条件 | 冰袋运输 |
| 产品介绍 |
RB-3, a PRC1 inhibitor, binds to RING1B-BMI1f , with a K d of 2.8 μM In Vitro RB-3 decreases the global level of H2A ubiquitination and induces differentiation in leukemia cell lines and primary acute myeloid leukemia (AML) samples. RB-3 inhibits H2A ubiquitination with an IC 50 of 1.6 μM. RB-3 inhibits PRC1 and disrupts the interaction with nucleosomes. RB-3 reduces colony formation in a mixed lineage leukemia (MLL)-eleven nineteen leukemia (ENL) model. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: TEX cells. Concentration: 6, 12, 25 μM. Incubation Time: 8d. Result: Dose-dependently increased C/EBPα-p42 protein levels. Form:Solid IC50& Target:Kd: 2.8 μM (RING1B-BMI1f) |
| 纯度 | ≥99% |
| Smiles | O=C(C1=C(C2=C3C=CNC3=CC=C2Cl)C(C(C)C)=C(C4=C5C=CNC5=CC=C4)N1)O |
|---|---|
| 分子量 | 417.89 |
| 溶解性 | DMSO : 100 mg/mL (239.30 mM; Need ultrasonic) |
|---|
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