| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Q408538-1ml |
1ml |
现货  |
|
| 英文别名 | (8α,9R)-6'-methoxy-cinchonan-9-ol,hydrochloride, hydrate (1:1:2) |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Quinine HCl Dihydrate |
| 生化机理 | 盐酸奎宁二水合物是一种白色晶体状 K+ 通道阻滞剂，用于治疗疟疾。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
水中溶解度:62.5 g/l (20 C)，溶于乙醇、甘油和氯仿，微溶于醚。K通道阻断剂。 Information Quinine HCl Dihydrate Quinine HCl Dihydrate is a white crystalline K+ channel blocker, used to treat malaria. Quinine blocks Cx36 and Cx50 junctional currents in a reversible and concentration-dependent manner with half maximal blocking concentrations of 32 mM and 73 mM, respectively. Quinine induces slow transitions between open and fully closed states that decreased open probability of the channel. Quinine thus offers a potentially useful method to block certain types of gap junction channels, including those between neurons that are formed by Cx36. Quinine, a K+ channel blocker, prevents formation of tumor necrosis factor (TNF) as well as the subsequent hepatic DNA fragmentation and liver enzyme leakage. Quinine elicits Fos-like immunoreactivity (FLI) concentrated in the medial third of the nucleus; acid elicited more broadly distributed FLI concentrated farther laterally. Quinine has a relatively weak effect on doxorubicin accumulation but was able to completely restore doxorubicin sensitivity in the resistant cells. Quinine also modifies the intracellular tolerance to doxorubicin, which suggests that it is able to modify drug distribution within the cells. Quinine primarily blocks the whole cell potassium currents (IK) in a voltage-dependent manner. Quinine also reduces the size of sodium currents (INa) in a use-dependent manner, while leaving calcium currents (ICa) relatively unaffected. In vivo
cell lines：Raw-264 macrophage Concentrations： Incubation Time： Powder Purity:≥99% |
| EC号 | 205-001-1 |
|---|---|
| Isomeric SMILES | COC1=CC2=C(C=CN=C2C=C1)[C@H]([C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)O.O.O.Cl |
| PubChem CID | 16211283 |
| 分子量 | 396.91 |
| Beilstein号 | 6112655 |
| Reaxy-Rn | 8370495 |
| 比旋光度 | -245 to -255 deg(C=2, 0.1mol/l HCl(calcd.on dried substance) |
|---|---|
| 熔点 | 160℃ |
| 象形图 | GHS08, GHS07 |
|---|---|
| 信号词 | Danger |
| 危险声明 |
H302: 吞食有害 H317: 可能引起皮肤过敏反应 H334: 吸入可能引起过敏或哮喘病症状或呼吸困难 H312: 皮肤接触有害 H332: 吸入有害 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P284: 如果通风不良，请佩戴呼吸防护装置。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P272: 被污染的工作服不允许离开工作场所 P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P330: 漱口 P301+P317: 如果被吞咽：请寻求医疗帮助。 P317: 寻求紧急医疗救助。 P342+P316: 如果出现呼吸道症状：立即寻求急救。 |
| WGK Germany | 3 |
| RTECS | VA7700000 |
| Merck Index | 8061 |
| 个人防护装备 | dust mask type N95 (US),Eyeshields,Faceshields,Gloves |
| 1. Shuying Li, Ying Zhang, Abdur Rauf Khan, Shuwang He, Yingxin Wang, Jiangkang Xu, Guangxi Zhai. (2020) Quantitative prediction of the bitterness of atomoxetine hydrochloride and taste-masked using hydroxypropyl-β-cyclodextrin: A biosensor evaluation and interaction study. Asian Journal of Pharmaceutical Sciences, 15 (492). [PMID:32952672] [10.1016/j.ajps.2019.11.001] |
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