| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| P755717-5mg |
5mg |
期货  |
|
| 规格或纯度 | γ-irradiated, BioReagent, 用于细胞培养, mol wt 30,000-70,000, lyophilized powder |
|---|---|
| 英文名称 | Poly-L-lysine hydrobromide（PDL HBr） |
| 生化机理 | 多聚-L-赖氨酸可用作包被物质，以促进细胞在培养物表面更好地附着。研究表明多聚-L-赖氨酸(PLL)包被的培养板可使细胞生长速度加快。在PLL包被的底物上培养间充质干细胞（MSC）时，它有助于维持其干性特征（stemness properties）并防止衰老。包被PLL的培养板表现出改善的MSC生长，并使与细胞粘附、分化、增殖和信号传导相关的基因表达上调。此外，PLL包被的多孔表面改善细胞增殖并有助于MSC的成骨分化。 |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
用0.5 ml的0.1 mg/ml溶液覆盖25cm2时，建议将其作为细胞培养基质。必须对每种细胞系和应用确定最佳附着条件。已将聚-L-赖氨酸氢溴酸盐用于将皮质组织的解离细胞附着进培养板。 也用于处理玻片，将样本固定其上进行免疫组化分析。应用： 多聚-L-赖氨酸是一种带正电荷的氨基酸聚合物，每个赖氨酸残基约有一个HBr。氢溴酸盐可使聚-L-赖氨酸以可溶于水的结晶形式存在。在β结构中可能会发现少量的产物，因为HBr干扰氨基与羧基或含N或O部分之间的氢键。聚-L-赖氨酸氢溴酸盐是非特异性附着因子，促进细胞附着在基质上。 Poly-L-lysine is a positively charged amino acid polymer with approximately one HBr per lysine residue. The hydrobromide allows the poly-L-lysine to be in a crystalline form soluble in water. A small amount of product may be found in the beta structure because the HBr interferes with hydrogen bonding between amino and either the carboxyl groups or N or O containing moieties. Poly-L-lysine hydrobromide is a nonspecific attachment factor in promoting cell adhesion to the substratum. Application: Recommended as a cell culture substratum when using 0.5 ml of a 0.1 mg/ml solution to coat 25 cm2. Optimal conditions for attachment must be determined for each cell line and application. Poly-L-lysine hydrobromide has been used to adhere the dissociated cells of cortical tissues into the culture plates. It has also been used to treat slides, to fix samples on it for immunohistochemical analysis. |
| 分子类型 | 蛋白质 |
|---|---|
| IIUPAC Name | (2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2,6-diaminohexanoyl]amino]hexanoyl]amino]hexanoic acid |
| INCHI | 1S/C18H38N6O4/c19-10-4-1-7-13(22)16(25)23-14(8-2-5-11-20)17(26)24-15(18(27)28)9-3-6-12-21/h13-15H,1-12,19-22H2,(H,23,25)(H,24,26)(H,27,28)/t13-,14-,15-/m0/s1 |
| InChi Key | WBSCNDJQPKSPII-KKUMJFAQSA-N |
| Smiles | C(CCN)CC(C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O)N |
| Isomeric SMILES | C(CCN)C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O)N |
| PubChem CID | 72363 |
| 溶解性 | H 2 O: soluble 50 mg/mL, clear, colorless |
|---|---|
| 分子量 | 402.500 g/mol |
| XLogP3 | -5.600 |
| 氢键供体数Hydrogen Bond Donor Count | 7 |
| 氢键受体数Hydrogen Bond Acceptor Count | 8 |
| 可旋转键计数Rotatable Bond Count | 17 |
| 精确质量Exact Mass | 402.295 Da |
| 单同位素质量Monoisotopic Mass | 402.295 Da |
| 拓扑极表面积Topological Polar Surface Area | 200.000 Ų |
| 重原子数Heavy Atom Count | 28 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 463.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 3 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 1. Xueming Bao, Biaobiao Yan, Yuanyuan Yu, Bo Xu, Li Cui, Man Zhou, Qiang Wang, Ping Wang. (2024) A facile cellulose finishing strategy through in-situ growth of sliver-doped manganese dioxide assisted by amine-quinone for improving indoor living quality. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 267 (131448). [PMID:38593901] [10.1016/j.ijbiomac.2024.131448] |
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