Pomaglumetad methionil hydrochloride

COA

级别和纯度:

≥98%

CAS编号: 635318-26-2
分子式: C₁₂H₁₉ClN₂O₇S₂
分子量: 402.87
PubChem编号: 66903228

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货号 (SKU)	包装规格	是否现货
P648455-5mg	5mg	期货
P648455-10mg	10mg	期货
P648455-25mg	25mg	期货
P648455-50mg	50mg	期货
P648455-100mg	100mg	期货

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Class C GPCR (399) GPCR/G Protein (3179) mGluR (175) 神经元信号传导 (3320)

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基本描述

别名	盐酸泊马美特甲硫胺
规格或纯度	≥98%
英文名称	Pomaglumetad methionil hydrochloride
生化机理	Pomaglumetad methionil hydrochloride（LY2140023 hydrochloride）是选择性 mGlu2/3 受体激动剂 LY404039 的一种口服活性蛋氨酸原药。Pomaglumetad methionil 盐酸盐具有研究精神分裂症的潜力。
储存温度	2-8°C储存
运输条件	冰袋运输
作用类型	激动剂
产品介绍	Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. Pomaglumetad methionil hydrochloride has the potential for schizophrenia research In Vitro Pomaglumetad methionil (LY2140023) is a high-affinity peptide transporter 1 (PEPT1) substrate with a K m value of ~30 µM. LY2140023 is active against [ 14 C]Gly-Sar with an IC 50 value of 0.018 mM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Pomaglumetad methionil (LY2140023; orally; 3-300 mg/kg; once daily for 7 days) dose-dependent increases the levels of the dopamine metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Fischer rats (approximately 250 g) Dosage: 3 mg/kg, 10 mg/kg, and 300 mg/kg Administration: Orally; once daily for 7 days Result: Dose-dependent increased the levels of the dopamine metabolites DOPAC and HVA. Form:Solid IC50& Target:mGluR2 mGluR3
纯度	≥98%

名称和识别符

IIUPAC Name	(1R,4S,5S,6S)-4-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-2,2-dioxo-2\u03bb6-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid;hydrochloride
INCHI	1S/C12H18N2O7S2.ClH/c1-22-3-2-5(13)9(15)14-12(11(18)19)4-23(20,21)8-6(7(8)12)10(16)17;/h5-8H,2-4,13H2,1H3,(H,14,15)(H,16,17)(H,18,19);1H/t5-,6+,7+,8-,12-;/m0./s1
InChi Key	KTYRTJLEXFSWRJ-LBMFEJOUSA-N
Smiles	CSCCC(C(=O)NC1(CS(=O)(=O)C2C1C2C(=O)O)C(=O)O)N.Cl
Isomeric SMILES	CSCC[C@@H](C(=O)N[C@]1(CS(=O)(=O)[C@@H]2[C@H]1[C@H]2C(=O)O)C(=O)O)N.Cl
PubChem CID	66903228
分子量	402.87

化学和物理性质

溶解性	DMSO : 25 mg/mL (62.05 mM; Need ultrasonic)

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