| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| P646536-5mg |
5mg |
期货  |
|
| 规格或纯度 | ≥98% |
|---|---|
| 英文名称 | PAC |
| 生化机理 | PAC 由 ADCs 连接器和 PROTACs 组成，与抗体连接。PAC 提取自专利 WO2017201449A1 中的化合物 LP2。与 PROTAC（不含抗体）相比，与抗体结合的 PAC 是一种更明显的雌激素受体-α（ERα）降解剂。 |
| 储存温度 | -20°C储存,充氩 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 产品介绍 |
PAC, consists the ADCs linker and PROTACs , conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab). In Vitro Treatment of HER2 expressing cells with HER2 antibody containing PAC Anti-HER2(Endox-XIAP) results in a marked decreased Estrogen Receptor-alpha (ERα) levels with an IC 50 of 132 ng/mL. The PROTAC-Antibody Conjugate (PAC) molecules comprise an antibody conjugated via a linker (L1) to a PROTAC, wherein the PROTAC comprises an ubiquitin E3 ligase binding group (“E3LB”), a linker (“L2”) and a protein binding group (“PB”). The following sections describe the components that comprise the PAC. To obtain a PAC having potent efficacy and a desirable therapeutic index, the following components are provided. 1. Antibody (Ab): The antibody portion of a PAC can target a cell that expresses an antigen whereby the antigen specific PAC is delivered intracellularly to the target cell, typically through endocytosis While PACs that comprise an antibody directed to an antigen that is not found on the cell surface may result in less specific intracellular delivery of the PROTAC portion into the cell, the PAC may still undergo pinocytosis. 2. Linkers (L1): A“linker” (L1) is a bifunctional or multifunctional moiety that can be used to link one or more PROTAC moieties (D) to an antibody (Ab) to form a PAC. In some embodiments, PACs can be prepared using a L1 having reactive functionalities for covalently attaching to the PROTAC and to the antibody. 3. PROTAC(D). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Estrogen receptor-alpha (ERα) |
| 纯度 | ≥98% |
| 分子量 | 1674.93 |
|---|
| 溶解性 | DMSO : 70 mg/mL (41.79 mM; Need ultrasonic) |
|---|
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