| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| P408094-1ml |
1ml |
现货  |
|
| 英文别名 | Phenethylbiguanide HCl | N-(2-phenylethyl)-imidodicarbonimidic diamide, hydrochloride (1:1) |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Phenformin (NSC-756501) HCl |
| 生化机理 | 盐酸苯乙双胍（NSC-756501，Phenethylbiguanide）是苯乙双胍的盐酸盐，属于双胍类抗糖尿病药物。它能激活 AMPK，增加其活性和磷酸化。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Phenformin hydrochloride 是一种双胍类的抗糖尿病剂，能够使 AMPK 活化。
Information Phenformin (NSC-756501) HCl Phenformin HCl (NSC-756501, Phenethylbiguanide) is a hydrochloride salt of phenformin that is an anti-diabetic drug from the biguanide class. It activates AMPK , increasing activity and phosphorylation. Phenformin stimulates the phosphorylation and activation of AMPKalpha1 and AMPKalpha2 without altering LKB1 activity. Phenformin increases AMPK activity and phosphorylation in the isolated heart, the increase in AMPK activity is always preceded by and correlated with increased cytosolic [AMP]. Phenformin is a 50-fold more potent inhibitor of mitochondrial complex I than metformin. Phenformin robustly induces apoptosis in LKB1 deficient NSCLC cell lines. Phenformin at 2 mM similarly induces AMPK signaling as shown by increased P-AMPK and P-Raptor levels. Phenformin induces higher levels of cellular stress, triggering induction of P-Ser51 eIF2α and its downstream target CHOP, and markers of apoptosis at later times. Phenformin induces a significant increase in survival and therapeutic response in KLluc mice following long-term treatment. Phenformin and AICAR increases AMPK activity in H441 cells in a dose-dependent fashion, stimulating the kinase maximally at 5-10 mm and 2 mm, respectively. Phenformin significantly decreases basal ion transport (measured as short circuit current) across H441 monolayers by approximately 50% compared with that of controls. Phenformin and AICAR significantly reduce amiloride-sensitive transepithelial Na+ transport compared with controls. Phenformin and AICAR suppress amiloride-sensitive Na+ transport across H441 cells via a pathway that includes activation of AMPK and inhibition of both apical Na+ entry through ENaC and basolateral Na+ extrusion via the Na+,K+-ATPase. Phenformin-treated rats reveals a tendency towards a decrease in blood insulin level (radioimmunoassay). In vivo Phenformin also increases levels of P-eIF2α and its target BiP/Grp78 in normal lung as well as in lung tumors of mice. cell lines： Concentrations： Incubation Time： Powder Purity:≥96% |
| EC号 | 212-637-3 |
|---|---|
| Isomeric SMILES | C1=CC=C(C=C1)CCN=C(N)N=C(N)N.Cl |
| UN Number | 2811 |
| Packing Group | I |
| 分子量 | 241.72 |
| Reaxy-Rn | 35474258 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=35474258&ln= |
| 象形图 | GHS07 |
|---|---|
| 信号词 | Warning |
| 危险声明 |
H302: 吞食有害 |
| 预防措施声明 |
P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P301+P317: 如果被吞咽：请寻求医疗帮助。 |
| WGK Germany | 3 |
| RTECS | DU2200000 |
| Class | 6.1 |
| 个人防护装备 | dust mask type N95 (US),Eyeshields,Gloves |
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