| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| O646672-5mg |
5mg |
期货  |
|
| 规格或纯度 | ≥98% |
|---|---|
| 英文名称 | OSIP-486823 |
| 生化机理 | OSIP-486823 是一种新型微管干扰剂，对蛋白激酶 G (PKG) 和微管都有不同的生物效应。 |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 产品介绍 |
OSIP-486823 is a novel microtubule -interfering agent with distinct biological effects on both protein kinase G (PKG) and microtubules. In Vitro OSIP486823 inhibits growth and induce apoptosis in SW480 human colon cancer cells, with IC 50 of 0.1 μM. OSIP-486823 (OSIP486823) causes depolymerization of microtubules in interphase cells, inhibit spindle formation in mitotic cells, and induce multinucleated cells. Exisulind and the potent synthetic derivative OSIP-486823 are members of a new class of drugs known as selective apoptotic antineoplastic drugs that target cyclic guanosine 3′,5′-monophosphate phosphodiesterases (cGMP-PDE). OSIP-486823 also disrupts microtubule polymerization, perturbs mitotic spindle function, and arrests cells in mitosis in human glioma cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Microtubule |
| 纯度 | ≥98% |
| IIUPAC Name | N-benzyl-2-[(3Z)-6-fluoro-2-methyl-3-[(3,4,5-trimethoxyphenyl)methylidene]inden-1-yl]acetamide |
|---|---|
| INCHI | 1S/C29H28FNO4/c1-18-23(12-20-13-26(33-2)29(35-4)27(14-20)34-3)22-11-10-21(30)15-25(22)24(18)16-28(32)31-17-19-8-6-5-7-9-19/h5-15H,16-17H2,1-4H3,(H,31,32)/b23-12- |
| InChi Key | KATLSKIJHJJAEB-FMCGGJTJSA-N |
| Smiles | CC1=C(C2=C(C1=CC3=CC(=C(C(=C3)OC)OC)OC)C=CC(=C2)F)CC(=O)NCC4=CC=CC=C4 |
| Isomeric SMILES | CC\1=C(C2=C(/C1=C\C3=CC(=C(C(=C3)OC)OC)OC)C=CC(=C2)F)CC(=O)NCC4=CC=CC=C4 |
| PubChem CID | 9934547 |
| MeSH Entry Terms | (5-fluoro-2-methyl-1-(3,4,5-trimethoxybenzylidene)-3-(N-benzyl)-indene)-acetamide;1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylsulfonyl)phenyl)methylene)-, (Z)-;Aptosyn;CP 248;CP248;exisulind;FGN-1;OSIP 486823;OSIP-486823;OSIP486823;sulindac su |
| 分子量 | 473.54 |
| 分子量 | 473.500 g/mol |
|---|---|
| XLogP3 | 5.500 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 5 |
| 可旋转键计数Rotatable Bond Count | 8 |
| 精确质量Exact Mass | 473.2 Da |
| 单同位素质量Monoisotopic Mass | 473.2 Da |
| 拓扑极表面积Topological Polar Surface Area | 56.800 Ų |
| 重原子数Heavy Atom Count | 35 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 776.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 1 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 1 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
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