| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| O420712-1ml |
1ml |
现货  |
|
| 英文别名 | Baicalein 7-O-diglucoside | HY-N1435 | CCG-270173 | Baicalin-7-diglucoside | MFCD22125002 | 5,6-dihydroxy-2-phenyl-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one | |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Oroxin B |
| 生化机理 | 从传统中药大黄素（Oroxylum indicum (L.) Vent）中分离出的黄酮类化合物之一--大黄素B（Hypocretin-2）可选择性地诱导恶性淋巴瘤细胞产生肿瘤抑制性ER应激，并具有抗氧化活性。Oroxin B能明显抑制SMMC-7721细胞的增殖并诱导其凋亡，这可能与抑制COX-2/VEGF和PTEN/PI3K/AKT信号通路密切相关。 |
| 储存温度 | 避光,-80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Information Oroxin B (Hypocretin-2), one of flavonoids isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent, selectively induces tumor-suppressive ER stress in malignant lymphoma cells and has antioxidant activity. Oroxin B significantly inhibits proliferation and induceapoptosis, which may be strongly associated with the inhibiting COX-2/VEGF and PTEN/PI3K/AKT signaling pathway in SMMC-7721 cells, Oroxin B potentially be used as a novel therapeutic agent for liver cancer. Targets PTEN ; COX-2 ; PI3K ; Akt |
| ALogP | -1.267 |
|---|---|
| hba_count | 6 |
| HBD Count | 9 |
| Rotatable Bond | 7 |
| IIUPAC Name | 5,6-dihydroxy-2-phenyl-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one |
|---|---|
| INCHI | 1S/C27H30O15/c28-8-15-19(31)22(34)24(36)26(41-15)38-9-16-20(32)23(35)25(37)27(42-16)40-14-7-13-17(21(33)18(14)30)11(29)6-12(39-13)10-4-2-1-3-5-10/h1-7,15-16,19-20,22-28,30-37H,8-9H2/t15-,16-,19-,20-,22+,23+,24-,25-,26-,27-/m1/s1 |
| InChi Key | HAYLVXFWJCKKDW-IJTBWITGSA-N |
| Smiles | C1=CC=C(C=C1)C2=CC(=O)C3=C(C(=C(C=C3O2)OC4C(C(C(C(O4)COC5C(C(C(C(O5)CO)O)O)O)O)O)O)O)O |
| Isomeric SMILES | C1=CC=C(C=C1)C2=CC(=O)C3=C(C(=C(C=C3O2)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O)O)O)O)O)O |
| 分子量 | 594.52 |
| Reaxy-Rn | 60206645 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=60206645&ln= |
| 敏感性 | 对光敏感 |
|---|---|
| DMSO(mg / mL) Max Solubility | 100 |
| DMSO(mM) Max Solubility | 168.203457556633 |
| 分子量 | 594.500 g/mol |
| XLogP3 | -1.300 |
| 氢键供体数Hydrogen Bond Donor Count | 9 |
| 氢键受体数Hydrogen Bond Acceptor Count | 15 |
| 可旋转键计数Rotatable Bond Count | 7 |
| 精确质量Exact Mass | 594.158 Da |
| 单同位素质量Monoisotopic Mass | 594.158 Da |
| 拓扑极表面积Topological Polar Surface Area | 245.000 Ų |
| 重原子数Heavy Atom Count | 42 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 958.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 10 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H302: 吞食有害 |
| 预防措施声明 |
P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P501: 将内容物/容器处理到。。。 P301+P312+P330: 如误吞咽：如感觉不适，呼叫急救中心/医生。漱口 |
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