NG-497

级别和纯度:

有货

关闭

货号 (SKU)	包装规格	是否现货	价格	数量
N656080-1ml	1ml	期货

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ATGL (4) Compound libraries (12333) Metabolic Enzyme/Protease (4889)

基本描述

规格或纯度	10mM in DMSO
英文名称	NG-497
生化机理	NG-497 是一种选择性人脂肪甘油三酯脂酶（ATGL）抑制剂，其靶标是具有酶活性的人 ATGL 蛋白样结构域。NG-497 具有潜在的肿瘤研究价值。
储存温度	避光,干燥,-80℃储存
运输条件	超低温冰袋运输
产品介绍	NG-497 is a selective human adipose triglyceride lipase ( ATGL ) inhibitor that targets the enzymatically active patatin-like domain of human ATGL. NG-497 has potential value for tumor research. In Vitro NG-497 selectively inactivates human and nonhuman primate ATGL but not structurally and functionally related lipid hydrolases and abolishes human adipocytes in a dose-dependent and reversible manner Lipolysis. NG-497 (40 μM, 80 min) reduces lipolysis-dependent respiration in HepG2 cells without impairing mitochondrial function through off-target effects. MCE has not independently confirmed the accuracy of these methods. They are for reference only.