| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| N409103-1ml |
1ml |
现货  |
|
| 英文别名 | 6-carbamimidoylnaphthalen-2-yl 4-guanidinobenzoate dimethanesulfonate |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Nafamostat mesilate (FUT-175) |
| 生化机理 | 甲磺酸萘莫司他（FUT-175）是一种合成丝氨酸蛋白酶抑制剂，在血液透析过程中用作抗凝剂。甲磺酸萘莫司他能阻断 SARS-CoV-2 的活化，被研究用作 COVID-19 的新治疗方案。甲磺酸萘莫司他能减轻炎症和细胞凋亡。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Nafamostat Mesylate是一种抗凝血剂。A highly effective tryptase inhibitor. Nafamostat甲磺酸盐是广谱的丝氨酸蛋白酶抑制剂，血管舒缓素抑制剂，能抑制血液凝固，还是潜在的补体抑制剂。Nafamostat甲磺酸盐通过降低颗粒酶活性和 CTL 细胞溶解抑制T细胞自身反应活性。Nafamostat mesylate 可抑制SARS-CoV-2 的激活。 Information Nafamostat mesilate (FUT-175) is a syntheticserine proteaseinhibitor, used as an anticoagulant during hemodialysis. Nafamostat mesylate blocks activation of SARS-CoV-2 and is investigated as a new treatment option for COVID-19. Nafamostat Mesilate attenua Nafamostat mesilate significantly inhibits the release of platelet beta-thromboglobulin (beta TG) at 60 and 120 min. Nafamostat mesilate (NM) prevents any significant release of neutrophil elastase; at 120 min, plasma elastase-alpha 1-antitrypsin complex is 0.16 mg/mL in the NM group and 1.24 mg/mL in the control group. Nafamostat mesilate completely inhibits formation of complexes of C1 inhibitor with kallikrein and FXIIa. Nafamostat mesilate inhibits several proteases which may be importantly involved in the pathophysiology of disseminated intravascular coagulation (DIC).Nafamostat mesilate inhibits extrinsic pathway activity (TF-F.VIIa mediated-F.Xa generation) in a concentration dependent manner with IC50 of 0.1 μM. Nafamostat mesilate produces concentration-dependent inhibition of the initial-phase transient component of biphasic ASIC3 currents with an IC50 value of approximately 2.5 mM. In vivo Nafamostat mesilate (10 mg/kg) inhibits scratching induced by tryptase but not by histamine and serotonin. Nafamostat mesilate (1-10 mg/kg) produces the dose-dependent inhibition of scratching induced by intradermal compound 48/80 (10 mg/site). Nafamostat mesilate (10 mg/kg) suppresses tryptase activity in the mouse skin. Nafamostat mesilate inhibits gemcitabine-induced NF-kappaB activation, enhances apoptosis by gemcitabine and suppresses pancreatic tumor growth. Nafamostat mesilate combined with Gemcitabine improves the body weight loss of mice induced by Gemicitabine. cell lines：WHCO1, WHCO5, and WHCO6 cell lines Concentrations： Incubation Time： Powder Purity:≥98% |
| Isomeric SMILES | CS(=O)(=O)O.CS(=O)(=O)O.C1=CC(=CC=C1C(=O)OC2=CC3=C(C=C2)C=C(C=C3)C(=N)N)N=C(N)N |
|---|---|
| 分子量 | 539.58 |
| Reaxy-Rn | 24731990 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24731990&ln= |
| 溶解性 | Solubility (25°C) In vitro DMSO: 26 mg/mL (201.3 mM); Water: 26 mg/mL (201.3 mM); Ethanol: 26 mg/mL |
|---|---|
| 熔点 | 260°C |
| 象形图 | GHS08 |
|---|---|
| 信号词 | Warning |
| 危险声明 |
H361: 怀疑破坏生育力或未出生的孩子 |
| 预防措施声明 |
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P203: 使用前，获取、阅读并遵守所有安全说明。 P318: 如果暴露或担心，请就医。 |
| RTECS | DG2736000 |
| Merck Index | 6350 |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
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