| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| N333809-1mg |
1mg |
现货  |
|
| 英文别名 | 4-Methyl-N-{3-[4-(~2~H_3_)methyl-1H-imidazol-1-yl]-5-(trifluoromethyl)phenyl}-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzamide | 4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]-N-[3-[4-(trideuteriomethyl)imidazol-1-yl]-5-(trifluoromethyl)phenyl]benzami |
|---|---|
| 规格或纯度 | ≥95 atom% D,≥95% |
| 英文名称 | Nilotinib-d3 |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
尼洛替尼-d3是尼洛替尼的标记类似物，起Bcr-Abl酪氨酸激酶拮抗剂的作用。研究表明，尼洛替尼-d3抑制HSCs的增殖，迁移和肌动蛋白丝形成。此外，尼洛替尼-d3可以通过减少bcl-2的表达和增加p53的表达，PARP的裂解以及PPARγ和TRAIL-R的表达增加，导致HSCs凋亡。尼洛替尼-d3通过抑制PDGF和TGFβ强烈抑制ERK和Akt1的磷酸化。或者，尼洛替尼-d3在慢性，加速和破伤期对慢性粒细胞白血病表现出显着的疗效。尼洛替尼-d3在抑制人类造血干细胞中的罗丹明123和赫斯特33342外排方面远比伊马替尼和达沙替尼有效。 Nilotinib-d3 is a labeled analogue of Nilotinib which functions as a Bcr-Abl tyrosine kinase antagonist. Studies suggest that Nilotinib-d3 inhibits proliferation, migration and actin filament formation in HSCs. In addition, Nilotinib-d3 can cause apoptosis in HSCs via reducing the expression of bcl-2 and increasing the expression p53, cleavage of PARP, along with an increased expression of PPARγ and TRAIL-R. Nilotinib-d3 strongly inhibits the phosphorylation of ERK and Akt1 via suppressing PDGF and TGFβ. Alternatively, Nilotinib-d3 shows significant efficacy towards chronic myeloid leukemia in chronic, accelerated, and blastic phases. Nilotinib-d3 is far more effective than imatinib and dasatinib at inhibiting rhodamine 123 and Hoechst 33342 efflux in human hematopoietic stem cells. |
| 纯度 | ≥95 atom% D,≥95% |
| IIUPAC Name | 4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]-N-[3-[4-(trideuteriomethyl)imidazol-1-yl]-5-(trifluoromethyl)phenyl]benzamide |
|---|---|
| INCHI | 1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)/i2D3 |
| InChi Key | HHZIURLSWUIHRB-BMSJAHLVSA-N |
| Smiles | CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)N3C=C(N=C3)C)NC4=NC=CC(=N4)C5=CN=CC=C5 |
| Isomeric SMILES | [2H]C([2H])([2H])C1=CN(C=N1)C2=CC(=CC(=C2)NC(=O)C3=CC(=C(C=C3)C)NC4=NC=CC(=N4)C5=CN=CC=C5)C(F)(F)F |
| 分子量 | 532.53 |
| Reaxy-Rn | 10737140 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=10737140&ln= |
| 溶解性 | Soluble in DMSO. |
|---|---|
| 熔点 | 227-230° C |
| 信号词 | 警告 |
|---|---|
| 危险声明 |
H302: 吞食有害 |
| 预防措施声明 |
P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 |
| RTECS | CV5581770 |
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 F2305828 |
分析证书 | N333809 |
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