Mito-LND

COA

级别和纯度:

≥97%

CAS编号: 2361564-49-8
分子式: C₄₃H₄₅BrCl₂N₃OP
分子量: 801.62
PubChem编号: 155977659

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货号 (SKU)	包装规格	是否现货
M647144-1mg	1mg	期货
M647144-5mg	5mg	期货
M647144-10mg	10mg	期货
M647144-25mg	25mg	期货
M647144-50mg	50mg	期货
M647144-100mg	100mg	期货

查看相关系列

Autophagy (2848) Glucose Metabolism (3713) Immunology/Inflammation (1938) Metabolic Enzyme/Protease (4889) Mitochondrial Metabolism (119) NF-κB (756) Reactive Oxygen Species (316)

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基本描述

别名	线粒体淋巴结清扫术
规格或纯度	≥97%
英文名称	Mito-LND
生化机理	Mito-LND（米托-洛尼达明）是一种口服活性线粒体靶向氧化磷酸化（OXPHOS）抑制剂。Mito-LND 可抑制线粒体生物能，刺激活性氧的形成，并诱导细胞自噬性死亡。
储存温度	-20°C储存,干燥
运输条件	超低温冰袋运输
作用类型	激活剂
产品介绍	Mito-LND (Mito-Lonidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation (OXPHOS). Mito-LND inhibits mitochondrial bioenergetics, stimulates the formation of reactive oxygen species , and induces autophagic cell death in lung cancer cells. In Vitro Mito-LND blocks lung cancer growth, migration, and invasion. Mito-LND inhibits cell growth of H2030BrM3 and A549 cells with IC 50 values of 0.74 µM and 0.69 µM, respectively. Mito-LND inhibits mitochondrial complex I and II activities with IC 50 values of 1.2 µM and 2.4 µM, respectively in H2030BrM3 cells. Mito-LND (1 µM) increases ROS generation in H2030BrM3 lung cancer cells. Mito-LND potently induces mitochondrial ROS generation in H2030BrM3 lung cancer cells. Mito-LND (2 µM) decreases the levels of phosphorylated AKT. Mito-LND also decreases the phosphorylation of P70S6K and other energy-sensing proteins in both the parental and metastatic lung cancer cell lines, indicating that Mito-LND specifically downregulates mTOR signaling. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Mito-LND (7.5 µmol/kg; oral gavage; 5 days per week; for 3 consecutive weeks) treatment markedly enhanced potency against both lung cancer progression and metastasis . Mito-LND also decreases the rate of growth of A549 tumor xenografts . Mito-LND treatment shows a marked decrease in lung cancer brain metastasis in NOD/SCID mice bearing H2030BrM3 cells . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Athymic nude mice (5 weeks) injected with H2030BrM3 cells Dosage: 7.5 µmol/kg Administration: Oral gavage; 5 days per week; for 3 consecutive weeks Result: Significantly decreased tumor progression. Form:Solid
纯度	≥97%

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

分子类型	未知
IIUPAC Name	10-[[1-[(2,4-dichlorophenyl)methyl]indazole-3-carbonyl]amino]decyl-triphenylphosphanium;bromide
INCHI	1S/C43H44Cl2N3OP.BrH/c44-35-29-28-34(40(45)32-35)33-48-41-27-17-16-26-39(41)42(47-48)43(49)46-30-18-5-3-1-2-4-6-19-31-50(36-20-10-7-11-21-36,37-22-12-8-13-23-37)38-24-14-9-15-25-38;/h7-17,20-29,32H,1-6,18-19,30-31,33H2;1H
InChi Key	XRSSFQSESARZNG-UHFFFAOYSA-N
Smiles	C1=CC=C(C=C1)[P+](CCCCCCCCCCNC(=O)C2=NN(C3=CC=CC=C32)CC4=C(C=C(C=C4)Cl)Cl)(C5=CC=CC=C5)C6=CC=CC=C6.[Br-]
Isomeric SMILES	C1=CC=C(C=C1)[P+](CCCCCCCCCCNC(=O)C2=NN(C3=CC=CC=C32)CC4=C(C=C(C=C4)Cl)Cl)(C5=CC=CC=C5)C6=CC=CC=C6.[Br-]
PubChem CID	155977659
分子量	801.62

化学和物理性质

溶解性	DMSO : 50 mg/mL (62.37 mM; Need ultrasonic)

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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