3-甲基腺嘌呤

选择性PI3K抑制剂

57篇引用文献

COA

级别和纯度:

≥98%

CAS编号: 5142-23-4
分子式: C₆H₇N₅
分子量: 149.15
MDL号: MFCD00010531
PubChem编号: 135398661

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货号 (SKU)	包装规格	是否现货
M129496-50mg	50mg	现货
M129496-100mg	100mg	现货
M129496-250mg	250mg	现货
M129496-1g	1g	现货
M129496-5g	5g	现货
M129496-25g	25g	现货

查看相关系列

Autophagy (2848) Endogenous Metabolite (978) Metabolic Enzyme/Protease (4889) Mitophagy (30) PI3K (243) PI3K/Akt/mTOR (764) 代谢物 (8911) 六元杂环化合物 (1701) 嘧啶类 (742)

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基本描述

别名	6-氨基-3-甲基嘌呤
英文别名	3-MA \| 3-methyl-3H-purin-6-amine (ACD/Name 4.0) \| 3-Methyl-3H-purin-6-amine # \| Purine, 3,6-dihydro-6-imino-3-methyl- \| AC-28818 \| FSASIHFSFGAIJM-UHFFFAOYSA-N \| HY-19312 \| W-202935 \| 3899G64TKW \| 3-Methyl-3H-adenine \| 3-methyl-3H-purin-6-ylamine (ACD/Name
规格或纯度	≥98%
英文名称	3-Methyladenine
生化机理	选择性PI3K抑制剂。抑制自噬的初始阶段。阻止自噬体形成。增强细胞凋亡。抑制蛋白质降解（IC 50 = 5 mM，大鼠肝细胞）。
运输条件	常规运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	3-Methyladenine is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM; blocks class I PI3K consistently, whereas suppression of class III PI3K is transient, and also blocks autophagosome formation. A multi-use inhibitor that protects cerebellar granule cells from apoptosis. 3-Methyladenine is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM; blocks class I PI3K consistently, whereas suppression of class III PI3K is transient, and also blocks autophagosome formation. A multi-use inhibitor that protects cerebellar granule cells from apoptosis.
纯度	≥98%

名称和识别符

IIUPAC Name	3-methyl-7H-purin-6-imine
INCHI	1S/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3,7H,1H3,(H,8,9)
InChi Key	ZPBYVFQJHWLTFB-UHFFFAOYSA-N
Smiles	CN1C=NC(=N)C2=C1N=CN2
Isomeric SMILES	CN1C=NC(=N)C2=C1N=CN2
分子量	149.15
Reaxy-Rn	512745
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=512745&ln=

化学和物理性质

溶解性	Soluble in DMSO (10 mg/ml), water (5 mg/ml), DMF (10 mg/ml), 95% ethanol, and 1N NaOH heating (30 mg/ml).
熔点	300 °C(dec.)
分子量	149.150 g/mol
XLogP3	-0.200
氢键供体数Hydrogen Bond Donor Count	2
氢键受体数Hydrogen Bond Acceptor Count	2
可旋转键计数Rotatable Bond Count	0
精确质量Exact Mass	149.07 Da
单同位素质量Monoisotopic Mass	149.07 Da
拓扑极表面积Topological Polar Surface Area	68.100 Å²
重原子数Heavy Atom Count	11
形式电荷Formal Charge	0
复杂度Complexity	211.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

象形图	GHS07
信号词	警告
危险声明	H302: 吞食有害 H315: 引起皮肤刺激 H319: 引起严重眼睛刺激
预防措施声明	P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P330: 漱口 P302+P352: 如皮肤沾染：用水充分清洗。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。
WGK Germany	3
RTECS	AU6520000

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批号(Lot Number)	证书类型	货号
F2002140	分析证书	M129496
L2301101	分析证书	M129496
J2317030	分析证书	M129496
G2507028	分析证书	M129496
G2429017	分析证书	M129496
J2210223	分析证书	M129496
J2210224	分析证书	M129496
J2210581	分析证书	M129496
J2210582	分析证书	M129496
L2110154	分析证书	M129496
L2110129	分析证书	M129496
L2110155	分析证书	M129496
L2110156	分析证书	M129496
I2126352	分析证书	M129496
C2314277	分析证书	M129496
A2115245	分析证书	M129496
A2115244	分析证书	M129496
G2311032	分析证书	M129496
J2210221	分析证书	M129496
B2419168	分析证书	M129496

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PI3K-Akt-mTORC信号通路

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PI3K-Akt-mTORC信号通路

PI3K-Akt-mTORC Signaling

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引用文献

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