6-(马来酰亚胺基)己酸琥珀酰亚胺酯

4篇引用文献

COA

级别和纯度:

≥98%

CAS编号: 55750-63-5
分子式: C₁₄H₁₆N₂O₆
分子量: 308.29
Beilstein号: 1499815
MDL号: MFCD00043043
PubChem编号: 5091655

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货号 (SKU)	包装规格	是否现货
M122240-50mg	50mg	现货
M122240-100mg	100mg	现货
M122240-250mg	250mg	现货
M122240-1g	1g	现货
M122240-5g	5g	现货
M122240-10g	10g	期货
M122240-25g	25g	期货
M122240-100g	100g	期货

查看相关系列

ADC Linker (354) Antibody-drug Conjugate/ADC Related (549) Hybrid Linkers (90) PROTAC linker (725) 酰亚胺 (272) 非杂环砌块 (8221) 马来酰亚胺连接体 (290)

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基本描述

别名	N-(ε-马来酰亚胺己酰氧)琥珀酰亚胺
英文别名	EMCS \| Nmicos \| Maleimide-(CH2)5-COONHS \| GS-6679 \| PD012171 \| N-Succinimidyl 6-maleimidocaproate \| AC-25054 \| 1H-Pyrrole-2,5-dione, 1-(6-((2,5-dioxo-1-pyrrolidinyl)oxy)-6-oxohexyl)- \| SY031503 \| N-Succinimidyl 6-Maleimidohexanoate \| 2,5-dioxopyrrolidin-1
规格或纯度	≥98%
英文名称	6-Maleimidohexanoic acid N-hydroxysuccinimide este
储存温度	-20°C储存,充氩
运输条件	超低温冰袋运输
产品介绍	A heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity. Typically, coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5) The second coupling is specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). Useful for preparation of enzyme immunoconjμgates and hapten carrier molecule conjμgates. Contains 9 atom linker. An extended aliphatic spacer stabilizes the maleimide prior to coupling compared to aromatic spacers.A heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity A heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity. Typically, coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5) The second coupling is specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. Contains 9 atom linker. An extended aliphatic spacer stabilizes the maleimide prior to coupling compared to aromatic spacers. A heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity
纯度	≥98%

名称和识别符

IIUPAC Name	(2,5-dioxopyrrolidin-1-yl) 6-(2,5-dioxopyrrol-1-yl)hexanoate
INCHI	1S/C14H16N2O6/c17-10-5-6-11(18)15(10)9-3-1-2-4-14(21)22-16-12(19)7-8-13(16)20/h5-6H,1-4,7-9H2
InChi Key	VLARLSIGSPVYHX-UHFFFAOYSA-N
Smiles	C1CC(=O)N(C1=O)OC(=O)CCCCCN2C(=O)C=CC2=O
Isomeric SMILES	C1CC(=O)N(C1=O)OC(=O)CCCCCN2C(=O)C=CC2=O
分子量	308.29
Beilstein号	1499815
Reaxy-Rn	1499815
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1499815&ln=

化学和物理性质

敏感性	对热、湿度、光线敏感
熔点	71°C
分子量	308.290 g/mol
XLogP3	-0.500
氢键供体数Hydrogen Bond Donor Count	0
氢键受体数Hydrogen Bond Acceptor Count	6
可旋转键计数Rotatable Bond Count	8
精确质量Exact Mass	308.101 Da
单同位素质量Monoisotopic Mass	308.101 Da
拓扑极表面积Topological Polar Surface Area	101.000 Å²
重原子数Heavy Atom Count	22
形式电荷Formal Charge	0
复杂度Complexity	520.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

象形图	GHS07
信号词	警告
危险声明	H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
预防措施声明	P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany	3
个人防护装备	dust mask type N95 (US)， Eyeshields， Gloves

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找到13个结果

批号(Lot Number)	证书类型	货号
I2102254	分析证书	M122240
I2102255	分析证书	M122240
I2102256	分析证书	M122240
H1512183	分析证书	M122240
D1930048	分析证书	M122240
H2205312	分析证书	M122240
H2205313	分析证书	M122240
H2205314	分析证书	M122240
H2205315	分析证书	M122240
H2205316	分析证书	M122240
H2205317	分析证书	M122240
F2506063	分析证书	M122240
E2230012	分析证书	M122240

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1. Y Nakano,M Mori,S Nishinohara,Y Takita,S Naito,A Horino,H Kato,M Taneichi,Y Ami,Y Suzaki,K Komuro,T Uchida. (1999-12-11) Antigen-specific, IgE-selective unresponsiveness induced by antigen-liposome conjugates. Comparison of four different conjugation methods for the coupling of antigen to liposome.. International archives of allergy and immunology, 120 ((3)): (199-208). [PMID:10592465]
2. Corinne Stannard,Petri Lehenkari,Jasminka Godovac-Zimmermann. (2003-11-26) Functional diversity of endothelin pathways in human lung fibroblasts may be based on structural diversity of the endothelin receptors.. Biochemistry, 42 ((47)): (13909-13918). [PMID:14636059]
3. Tingting Zhang,Weili Yu,Yanfei Wang,Tao Hu. (2015-05-13) Moderate PEGylation of the carrier protein improves the polysaccharide-specific immunogenicity of meningococcal group A polysaccharide conjugate vaccine.. Vaccine, 33 ((28)): (3208-3214). [PMID:25964170]
4. N J Maeji,G Tribbick,A M Bray,H M Geysen. (1992-01-21) Simultaneous multiple synthesis of peptide-carrier conjugates.. Journal of immunological methods, 146 ((1)): (83-90). [PMID:1735784]
5. Tatsuya Hattori,Kenta Nakashima,Takayuki Marutani,Yoshiaki Kiso,Yoshisuke Nishi,Hidehito Mukai. (2015-05-20) Successful acquisition of a neutralizing monoclonal antibody against a\xa0novel neutrophil-activating peptide, mitocryptide-1.. Biochemical and biophysical research communications, 463 ((1-2)): (54-59). [PMID:25986736]
6. Eun A Kim,David F Blair. (2015-07-22) Function of the Histone-Like Protein H-NS in Motility of Escherichia coli: Multiple Regulatory Roles Rather than Direct Action at the Flagellar Motor.. Journal of bacteriology, 197 ((19)): (3110-3120). [PMID:26195595]
7. Chao Zhang, HongLei Zhang, MengNan Han, XueLi Yang, ChaoHong Pei, ZhiDong Xu, Jie Du, Wei Li, Shengxi Chen. (2019) DNA–affibody nanoparticle delivery system for cisplatin-based breast cancer chemotherapy. RSC Advances, 9 (4): (1982-1989). [PMID:35516156] [10.1039/C8RA08735K]
8. Fengyin Liu, Zijian Chen, Yudong Shen, Yuanming Sun, Jinyi Yang, Hong Wang, Hongtao Lei, Zhenlin Xu. (2018) Hapten synthesis and production of specific antibody against 3-amino-5-morpholinomethyl-2-oxazolidone for immunoassay without derivatisation. FOOD AND AGRICULTURAL IMMUNOLOGY, [10.1080/09540105.2017.1376038]
9. Na Zhao, Baoyan Wu, Xianglong Hu, Da Xing. (2017) NIR-triggered high-efficient photodynamic and chemo-cascade therapy using caspase-3 responsive functionalized upconversion nanoparticles. BIOMATERIALS, 141 (40). [PMID:28666101] [10.1016/j.biomaterials.2017.06.031]
10. Dong Wei, Wang Guihu, Chai Yichao, Li Wenjuan, Liu Shichang, Liu Huasheng, Guo Wenlei, Li Senyang, He Xinrui, Wan Mingxi, Li Zongfang, Zong Yujin. (2025) Two-step ultrasonic cavitation controlled delivery of brain exogenous nucleic acids for ischemic stroke using acoustic-cationic-polymeric-nanodroplets. Drug Delivery and Translational Research, (1-21). [PMID:40048146] [10.1007/s13346-025-01828-6]

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